Transforming growth factor-β and breast cancer: Tumor promoting effects of transforming growth factor-β

The transforming growth factor (TGF)-βs are potent growth inhibitors of normal epithelial cells. In established tumor cell systems, however, the preponderant experimental evidence suggests that TGF-βs can foster tumor-host interactions that indirectly support the viability and/or progression of cancer cells. The timing of this 'TGF-β switch' during the progressive transformation of epithelial cells is not clear. More recent evidence also suggests that autocrine TGF-β signaling is operative in some tumor cells, and can also contribute to tumor invasiveness and metastases independent of an effect on nontumor cells. The dissociation of antiproliferative and matrix associated effects of autocrine TGF-β signaling at a transcriptional level provides for a mechanism(s) by which cancer cells can selectively use this signaling pathway for tumor progression. Data in support of the cellular and molecular mechanisms by which TGF-β signaling can accelerate the natural history of tumors will be reviewed in this section

Technology-Enhanced Organizational Learning: A Systematic Literature Review

E-Learning systems are receiving ever increasing attention in, academia, businesses as well as in public administrations. Managers and employee who need efficient forms of training as well as learning flow within the organization, do not have to gather in a place at the same time, or to travel far away for attending courses. Contemporary affordances of e-learning systems allow them to perform different jobs or tasks for training courses according to their own scheduling, as well as collaborate and share knowledge and experiences that results rich learning flow within the organization. The purpose of this article is to provide a systematic review of empirical studies in the intersection of e-learning and organizational learning in order to summarize the current findings and guide future research. Forty peer-reviewed articles were collected from a systematic literature search and analyzed based on a categorization of their main elements. This survey identifies five major directions Technology-Enhanced Organizational learning has been focused during the last decade. Future research should leverage on big data produced from the platforms and investigate how the incorporation of advanced learning technologies (e.g., learning analytics, personalized learning) can help increasing organizational value

Technology-Enhanced Organizational Learning: A Systematic Literature Review

acceptedVersio