Overview of NMR in drug design

NMR spectroscopy is an extremely valuable tool in the pharmaceutical sciences. This chapter gives an overview of the use of this tool in drug design. It sets the scene for the specialist chapters that are included in this Handbook of Modern Magnetic Resonance

Current approaches to the isolation and structural elucidation of active compounds from natural products

The essence of medicinal plants, either as pure compounds or as standardized extracts, provides unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Due to an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, the isolation of compounds from edible plants has grown. Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. The focus of this chapter is on revised current analytical methodologies, which include the extraction, isolation, and identification of bioactive principles in natural products. Chromatographic techniques such as LC and spectroscopic methods like NMR and MS will be discussed.UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de QuímicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA