WNT signalling in prostate cancer

Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-resistant prostate cancer. WNT signalling is also important in the prostate tumour microenvironment, in which WNT proteins secreted by the tumour stroma promote resistance to therapy, and in prostate cancer stem or progenitor cells, in which WNT-β-catenin signals promote self-renewal or expansion. Preclinical studies have demonstrated the potential of inhibitors that target WNT receptor complexes at the cell membrane or that block the interaction of β-catenin with lymphoid enhancer-binding factor 1 and the androgen receptor, in preventing prostate cancer progression. Some WNT signalling inhibitors are in phase I trials, but they have yet to be tested in patients with prostate cancer

Trajectories of cell-cycle progression from fixed cell populations

An accurate dissection of sources of cell-to-cell variability is crucial for quantitative biology at the single-cell level but has been challenging for the cell cycle. We present Cycler, a robust method that constructs a continuous trajectory of cell-cycle progression from images of fixed cells. Cycler handles heterogeneous microenvironments and does not require perturbations or genetic markers, making it generally applicable to quantifying multiple sources of cell-to-cell variability in mammalian cells

JWST Photometric Time-delay and Magnification Measurements for the Triply Imaged Type Ia “SN H0pe” at z = 1.78

Abstract Supernova (SN) SN H0pe is a gravitationally lensed, triply imaged, Type Ia SN (SN Ia) discovered in James Webb Space Telescope imaging of the PLCK G165.7+67.0 cluster of galaxies. Well-observed multiply imaged SNe provide a rare opportunity to constrain the Hubble constant (H 0), by measuring the relative time delay between the images and modeling the foreground mass distribution. SN H0pe is located at z = 1.783 and is the first SN Ia with sufficient light-curve sampling and long enough time delays for an H 0 inference. Here we present photometric time-delay measurements and SN properties of SN H0pe. Using JWST/NIRCam photometry, we measure time delays of Δt ab = − 116.6 − 9.3 + 10.8 observer-frame days and Δt cb = − 48.6 − 4.0 + 3.6 observer-frame days relative to the last image to arrive (image 2b; all uncertainties are 1σ), which corresponds to a ∼5.6% uncertainty contribution for H 0 assuming 70 km s−1 Mpc−1. We also constrain the absolute magnification of each image to μ a = 4.3 − 1.8 + 1.6 , μ b = 7.6 − 2.6 + 3.6 , μ c = 6.4 − 1.5 + 1.6 by comparing the observed peak near-IR magnitude of SN H0pe to the nonlensed population of SNe Ia.</jats:p