Oxidative stress action in cellular aging

Various theories try to explain the biological aging by changing the functions and structure of organic systems and cells. During lifetime, free radicals in the oxidative stress lead to lipid peroxidation of cellular membranes, homeostasis imbalance, chemical residues formation, gene mutations in DNA, dysfunction of certain organelles, and the arise of diseases due to cell death and/or injury. This review describes the action of oxidative stress in the cells aging process, emphasizing the factors such as cellular oxidative damage, its consequences and the main protective measures taken to prevent or delay this process. Tests with antioxidants: vitamins A, E and C, flavonoids, carotenoids and minerals, the practice of caloric restriction and physical exercise, seeking the beneficial effects on human health, increasing longevity, reducing the level of oxidative stress, slowing the cellular senescence and origin of certain diseases, are discussed.<br>Diferentes teorias tentam explicar o envelhecimento biológico através da alteração das funções e estrutura dos sistemas orgânicos e células. Ao longo da vida, os radicais livres presentes no estresse oxidativo conduzem à peroxidação dos lipídios das membranas celulares, desequilíbrio da homeostase, formação de resíduos químicos, mutações gênicas no DNA, disfunção de certas organelas, bem como ao surgimento de doenças devido à lesão e/ou morte celular. Nesta revisão descreve-se a ação do estresse oxidativo no processo de envelhecimento das células, enfatizando fatores como os danos oxidativos celulares, suas conseqüências e as principais medidas protetoras adotadas para se prevenir ou retardar este processo. Testes com antioxidantes: vitaminas A, E e C, flavonóides, carotenóides e minerais; a prática de restrição calórica e exercícios físicos, que buscam efeitos benéficos sobre a saúde humana, aumentando a longevidade, reduzindo o nível de estresse oxidativo, retardando a senescência celular e a origem de certas doenças, são discutidos

Soft impact dynamics of deformable bodies

Systems constituted by impacting beams and rods of non-negligible mass are often encountered in many applications of engineering practice. The impact between two rigid bodies is an intrinsically indetermi- nate problem due to the arbitrariness of the velocities after the instantaneous impact and implicates an infinite value of the contact force. The arbitrariness of after-impact velocities is solved by releasing the impenetrability condition as an internal constraint of the bodies and by allowing for elastic deformations at contact during an impact of finite duration. In this paper, the latter goal is achieved by interposing a concentrate spring between a beam and a rod at their contact point, simulating the deformability of impacting bodies at the interaction zones. A reliable and convenient method for determining impact forces is also presented. An example of engineering interest is carried out: a flexible beam that impacts on an axially deformable strut. The solution of motion under a harmonic excitation of the beam built-in base is found in terms of transverse and axial displacements of the beam and rod, respectively, by superimposition of a finite number of modal contributions. Numerical investigations are performed in order to examine the influence of the rigidity of the contact spring and of the ratio between the first natural frequencies of the beam and the rod, respectively, on the system response, namely impact velocity, maximum displacement, spring stretching and contact force. Impact velocity diagrams, non- linear resonance curves and phase portraits are presented to determine regions of periodic motion with impacts and the appearance of chaotic solutions, and parameter ranges where the functionality of the non-structural element is at ris