Hypoxia-inducible factor 1 alpha expression is an indicator of invasiveness in uterine cervical tumors

Background: Hypoxia is a common feature of cancers. Hypoxia-inducible factor 1A (HIF1A) is a causative agent that changes the transcriptional response of tumors under hypoxia. Some alterations lead to an increase in HIF1A activity and this supports other critical pathways leading to angiogenesis, metabolic adaptation and tumor progression. This retrospective study was designed to evaluate the differences of tissue expressions of HIF1A in a spectrum of cervical neoplasms.Methods: Tissue expression of HIF1A was studied in a total of 107 formalin-fixed, paraffin-embedded uterine cervical tumors specimens and its association with different clinicopathologic parameters was evaluated.Results: In this series, there were 30 low and 29 high grade cervical intraepithelial neoplasms (CINs), 27 squamous cell carcinomas, 15 adenosquamous carcinomas and 6 adenocarcinomas. Strong and diffuse nuclear staining was evaluated as positive HIF1A expression. Positive HIF-1 alpha expression was detected in 7 (25.9%) of squamous cell carcinomas, 1 of adenocarcinomas (16.7%) and only 1 of HGSILs (3.4%). Statistically it was determined that the positivity rate of strong nuclear HIF1A expression was significantly higher in invasive carcinomas when compared with in non-invasive squamous cell carcinomas (p=0.07). Contrary, there was no statistically significant difference according to the subtypes of carcinomas due to scarce number of cases with adenocarcinoma (p=0.188).Conclusions: Our findings were demonstrated to link of nuclear HIF1A expression and the invasive characters of uterine neoplasms. As a result, HIF-1 alpha expression may be important in foreseeing of the invasion and tumor progression

Colonic Metastasis from Primary Tonsillar Squamous Cell Carcinoma: A Rare Cause of Large Bowel Obstruction

ABSTRACT Tonsillar squamous cell carcinoma is a subtype of head and neck cancer that rarely metastasizes to the colorectal system. Colonic metastasis secondary to primary tonsillar squamous cell carcinoma is a very rare clinical occurrence with unclear pathogenesis. Palliative chemo-radiation and surgery are recommended for this rare condition, which is generally seen in advanced stages. Here, we aimed to report a case of a 70-year male who underwent palliative surgery due to the symptoms of mechanical bowel obstruction as a result of colonic metastasis of tonsillar carcinoma and review the relevant literature.</p

Nadir Bir Batın içi Abse Nedeni, Jejunal Divertikülit Perforasyonu

Jejunal divertikulozis genellikle asemptomatik seyreden çok nadir görülen bir hastalıktır. Obstruksiyon, kanama ve perforasyon gibi divertikülite sekonder oluşan ciddi komplikasyonlar geç tanı konulduğunda yaşamı tehdit edici olabilir. Seksen iki yaşında erkek hasta acil servise karın ağrısı şikayetiyle başvurmuş olup, fizik muayenesi akut batın ve peritonit ile uyumlu idi. Bilgisayarlı abdomen tomografide serbest hava ve apse nedeniyle hastaya perforasyon tanısı konuldu. Eksploratif laparatomi yapılan hastaya ameliyat sırasında peroperatif jejunal divertikülit perforasyonu tanısı konuldu. Segmental ince bağırsak rezeksiyonu ve uçtan uca anastomoz uygulandı. Ameliyat sonrası 25. günde komplikasyonsuz olarak taburcu edildi. Bu olgu sunumunda, gecikmiş tanı nedeniyle jejunal divertikülit perforasyonu olan yaşlı bir hastada nadir bir akut karın nedeninin sunulması amaçlanmıştır

Castleman's Disease Mimicking a Parotid Gland Tumor

© 2018 by Türkiye Klinikleri.Castleman disease (CD) is a rare benign lymphoproliferative disorder of unknown etiology, typically presenting as a solitary mediastinal mass. The head and neck region is the most common site; however, the salivary glands are rarely affected. We present a rare case of a 59-yearold male patient with mixed type CD localized in the parotid gland. The patient underwent a left superficial parotidectomy with a clinical prediagnosis of mucoepidermoid carcinoma. H&E stained sections showed mostly preserved lymph node architecture. Some lymphoid follicles had atrophic germinal centers and mantle zones was expanded. Also there were sclerotic blood vessels radially penetrated the germinal centers and the overall appearance of the follicle was resembling a lollipop. The diagnosis was CD, mixed type. For the accurate diagnosis of this entity, histopathological examination should be performed and physicians should kept in mind this clinical entity so patients can receive adequate and early treatment

Castleman’s disease mimicking a parotid gland tumor Parotis bezi tümörünü taklit eden castleman hastalığı

© 2018 by Türkiye Klinikleri.Castleman disease (CD) is a rare benign lymphoproliferative disorder of unknown etiology, typically presenting as a solitary mediastinal mass. The head and neck region is the most common site; however, the salivary glands are rarely affected. We present a rare case of a 59-yearold male patient with mixed type CD localized in the parotid gland. The patient underwent a left superficial parotidectomy with a clinical prediagnosis of mucoepidermoid carcinoma. H&E stained sections showed mostly preserved lymph node architecture. Some lymphoid follicles had atrophic germinal centers and mantle zones was expanded. Also there were sclerotic blood vessels radially penetrated the germinal centers and the overall appearance of the follicle was resembling a lollipop. The diagnosis was CD, mixed type. For the accurate diagnosis of this entity, histopathological examination should be performed and physicians should kept in mind this clinical entity so patients can receive adequate and early treatment