The Role of Age in Life Satisfaction Judgements among Educated Adults in Ado–Ekiti

This study investigated the role of age in life satisfaction judgements amongeducated adults in Ado – Ekiti. Employing a sample of 544 participants ofeducated adults in the age cohorts of 20 – 39 years (276), 40 – 59 years(179), and 60+ years (89), selected through a multi-stage sampling, andadministering on them Life Satisfaction Index Satisfaction Index, and aPersonal Data Inventory, analyses of data using One-way ANOVA withScheffe Post Hoc Analysis revealed that there is a developmental trend as lifesatisfaction decreases among educated adults as age increases 20 – 39 years(mean value = 38.48), 40 – 59 years (mean value = 35.85), 60+ years (mean value = 31.57). Based on the finding, recommendations were made torelevant agencies, governments and policy makers, in the lives of Nigerian adults to use the opportunity of the knowledge of findings to create avenuesthat will enhance satisfaction with life among Nigerian adults

Evaluation of the antioxidant and hepatoprotective properties of the methanolic extract of Acalypha racemosa leaf in carbon tetrachloride-treated rats

The effects of simultaneous treatment of CCl4 with 60 and 120 mg/kg body weight of methanolic extract of Acalypha racemosa on rat liver were evaluated. Analysis of serum alanine aminotransferase (ALT)and aspartate aminotransferase (AST) activities with those of the concentrations of albumin, total protein, unconjugated and total bilirubin was carried out. The malondialdehyde (MDA) content of liverwas determined to investigate a probable mechanism of action of the extract. Histopathological studies were carried out to confirm the observed changes. Administration of CCl4 alone to rats significantlyincreased total bilirubin concentration and the activities of ALT and AST (

Analysis of effects of extension teaching methods on farmers’ level of cassava and maize production in Ogun State, Nigeria

This study analyzed the effects of extension teaching methods used by Ogun State (Nigeria) Agricultural Development Programme’s extension agents on farmers’ level of production in maize and cassava. The sampleincluded 210 randomly selected farmers, comprising adopters and non-adopters of introduced agricultural technologies. The result indicated a high level of awareness and low level of adoption of some essential components of the recommended technologies such as fertilizer andherbicide application. Adopting the technologies is affected by high cost and non-availability of inputs as and when needed. The study also showed that the type of extension teaching methods used by extension agentsor which farmers had access to have varying effects on their levels of production. The use of a combination of individual, group and mass methods of extension teaching had the best association and effect on production output. The study recommended that non-adopters (and lowadopters) should be identified and extension efforts concentrated toward them, essential inputs should be provided at the right time and at affordable prices, organic manure (e.g. compost) should be used as a substitute for fertilizer by farmers where it is unavailable, and that theuse of a combination of extension teaching methods and media by extension agents should be encouraged

Myositis Ossificans Circumscripta of the Supra-orbital Region: A Case Report

Myositis ossificans circumscripta is a pathological condition characterized by formation of bony tissue within the skeletal muscles following repeated trauma. A case of myositis ossificans circumscripta of thesupra-orbital region in a 25-year-old man is presented and the pertinent literature is reviewed. To the best our knowledge this benign lesion has not been reported previously in the orbital region the world literature. Clinically the patient presented with a swelling and proptosis of the right eye. Radiologically there was a rounded opacity with well defined margin. Lesion was initially misdiagnosed as a fibroosseous lesion; however microscopic examination indicated matured myositis ossificans. Lesion was excised via a bicoronal flap. Careful clinical, radiological and pathologic evaluation is required to make this uncommon diagnosis in an unusual location such as the supra-orbital region to avoid unnecessary surgical mutilation of the patien

Catalytic cofactors (Mg2+ and Zn2+ ions) influence the pattern of vanadate Inhibition of the monoesterase activity of calf intestinal alkaline phosphatase

The mechanism of modulation of vanadate inhibition of alkaline phosphatase activity by catalytic cofactors has not been fully characterized. We investigated the effect of the interaction of catalytic cofactors (Mg2+ and Zn2+) and vanadate (an active site inhibitor) on the rate of hydrolysis of para-nitrophenyl phosphate (pNPP) (monoesterase reaction) by calf intestinal alkaline phosphatase (CIAP). The results showed that vanadate significantly inhibited ʻcofactor-freeʼ CIAP, and the inhibition was relieved by the presence of the catalytic cofactors in the reaction. Our results show that the absence of the cofactors did not significantly alter the Km of the reaction, but caused a decrease in the Vmax. Kinetic analyses showed that vanadate inhibited CIAP-catalyzed hydrolysis of pNPP by decreasing the Vmax and increasing the Km of the reaction. The presence of cofactors in the reaction alleviated the effect of vanadate by increasing the Vmax and decreasing the Km. The activity of the dialyzed CIAP was increased by the addition of catalytic cofactors to vanadate-inhibited enzyme. This study provides preliminary data that reversible inhibition of CIAP is subject to the influence of catalytic cofactors. Further studies will reveal detailed mechanistic aspects of this observation and its significance in the biological system.Keywords: alkaline phosphatase, monoesterase reaction, vanadate inhibition, catalytic cofactor

Cofactor interactions in the activation of tissue non-specific alkaline phosphatase: Synergistic effects of Zn2+ and Mg2+ ions

The interactions of Mg2+ and Zn2+ ions in the activation of non-specific tissue alkaline phosphatase were investigated using crude extracts of rat kidney. Activation of alkaline phosphatase by the metal ions was accompanied by changes in the kinetic parameters of  nitrophenylphosphate hydrolysis. The results suggest some synergistic interactions between Mg2+ and Zn2+ ions in promoting the hydrolysis of p-nitrophenylphosphate by alkaline phosphatase. The results show that assays of alkaline phosphatase activity in homogenised tissuesamples will give better responses if both Mg2+ and Zn2+ ions are included in the reaction

Congenital bilateral fusion of the maxillomandibular alveolar processes with craniosynostosis: report ofa rare case

A rare congenital anomaly of maxillomandibular fusion with pectus excavatum and craniosynostosis in a neonate is presented. The child was kept alive by nasogastric tube feeding.Amodification of classification of syngnathia is proposed. The aetiopathogenesis and difficulty in management in our environment are discussed. Keywords: Bilateral; alveolar fusion; craniosynostosis; pectus excavatum Nigerian Journal of Clinical Practice Vol. 11 (1) 2008: pp.78-8