Markers of liver function and inflammatory cytokines modulation by aerobic versus resisted exercise training for nonalcoholic steatohepatitis patients

Background: Non-alcoholic steatohepatitis is a growing public health problem with no approved therapy; as cytokines and other pro-inflammatory mediators may each play a role in transition of steatosis to NASH which is projected to be the leading cause of liver transplantation in the United States by 2020.Objective: The aim of this study was to compare the impact of aerobic versus resisted exercise training on inflammatory cytokines and markers of liver function in patients with nonalcoholic steatohepatitis.Material and Methods: Fifty patients with NASH were included in the study and divided into two subgroups. Participants were included into 2 equal groups; the first group (A) received aerobic exercise training. The second group (B) received resisted exercise training three times a week for 3 months.Results: The mean values of TNF- α, IL6, IL8, ALT and AST were significantly decreased in group (A) and group (B).Also; there was a significant difference between both groups after treatment.Conclusion: Aerobic exercise training modulates inflammatory cytokine levels and markers of liver function in patients with nonalcoholic steatohepatitis.Keywords: Aerobic Exercise; Resisted Exercises; Inflammatory Cytokine; markers of liver function; Non-alcoholicsteatohepatitis

Liver enzymes and psychological well-being response to aerobic exercise training in patients with chronic hepatitis C

Background: Chronic hepatitis C (CHC) is a medical condition that has broad implications for a person’s physical and psychological health.Objective: The aim of this study was to detect changes in liver enzymes and psychological well-being in response to aerobic exercise training in patients with CHC.Material and Methods: Fifty CHC patients were included in two equal  groups. The first group (A) received aerobic exercise training in addition to their regular medical treatment. The second group (B) received no training and only has their regular medical treatment. The program consisted of three sessions per week for three months.Results: There was a significant decrease in mean values of Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Aspartate  Aminotransferase (AST), Gamma – Glutamyltransferase (GGT) , Beck  Depression Inventory (BDI ) & Profile of Mood States(POMS) and increase in Rosenberg Self-Esteem Scale (RSES) in group (A) after treatments, but the changes in group (B) were not significant. Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.Conclusion: Aerobic exercise training improves hepatic enzymes and psychological well-being in patients with chronic hepatitis C.Key words: liver enzymes; psychological well-being; aerobic exercise; chronic hepatitis C