19 research outputs found

    Analysis of p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ gene methylation in patients with oral squamous cell carcinoma

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    [Extract] Cancer is the third leading cause of death in Iran, after coronary heart disease and accidents (Mousavi and Somi 2009). Apart from alterations in the various cellular oncogenes, dysregulation of tumour suppressor genes is an important event in the pathogenesis of cancer. Tumor suppressor genes, especially those involved in call cycle regulation, are inactivated frequently in a variety of cancers (Cunningham and Roussel 2001). Two closely linked tumor suppressor genes, p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ, are located at chromosome 9p21; they encode their respective cyclin-dependent kinase inhibitors (CDKI)- p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ
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