27 research outputs found

    Genomic analysis on pygmy hog reveals extensive interbreeding during wild boar expansion

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    Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa, most likely from East Asia during the Plio-Pleistocene (2–1Mya). In recent studies, based on genome-wide information, it was hypothesized that wild boar did not replace the species it encountered, but instead exchanged genetic materials with them through admixture. The highly endangered pygmy hog (Porcula salvania) is the only suid species in mainland Eurasia known to have outlived this expansion, and therefore provides a unique opportunity to test this hybridization hypothesis. Analyses of pygmy hog genomes indicate that despite large phylogenetic divergence (~2 My), wild boar and pygmy hog did indeed interbreed as the former expanded across Eurasia. In addition, we also assess the taxonomic placement of the donor of another introgression, pertaining to a now-extinct species with a deep phylogenetic placement in the Suidae tree. Altogether, our analyses indicate that the rapid spread of wild boar was facilitated by inter-specific/inter-generic admixtures.</p

    Lipoprotein changes following consumption of Lutein-enriched eggs are associated with enhanced Lutein bioavailability

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    Lutein is concentrated in the retina and since it cannot be synthesized by the human body, its uptake depends on nutritional intake. Lutein-enriched eggs are a good lutein source, but whether changes in lipoprotein status following lutein-enriched egg consumption may affect an individual’s lutein response is not yet clear. Data from three intervention trials with lutein-enriched eggs or products made from the enriched egg yolks were combined (n=294) and analyzed to investigate the dynamics of the lutein response in relation to lipoprotein levels. Cross sectional correlation was tested at baseline between lutein and lipoprotein profiles in all participants. Subsequently two groups were selected from the combined database whereby individuals receiving lutein-enriched egg yolks (n=137) were compared with controls not receiving eggs (n=117). Significant correlations between blood lutein concentrations and total cholesterol (r=0.309; p&lt;0.001), HDL-C (r=0.246; p&lt;0.001), LDL-C (r=0.241; p&lt;0.001), ApoA1 (r=0.301; p&lt;0.001), and ApoB100 (r=0.199; p&lt;0.005) concentrations, but not with serum triglycerides were found at baseline. Following a three to twelve month intervention, blood lutein concentrations increased from 238 to 463 ng/ml (p&lt;0.001) in the lutein group, whereas levels in controls remained unchanged. The lutein increase in the lutein-enriched egg group correlated significantly with changes in total cholesterol, HDL-C, LDL-C, ApoA1 and ApoB100 concentrations. To conclude, individuals showing the largest lipoprotein increase following egg consumption were also those with the strongest increase in blood lutein concentration. This indicates that therapies directed at altering lipoprotein levels may indirectly affect lutein bioavailability

    Increased macular pigment optical density and visual acuity following consumption of a buttermilk drink containing Lutein-Enriched egg yolks: a randomized, double-blind, placebo-controlled trial

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    Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group. MPOD, best corrected visual acuity (BCVA, logMAR), and dark adaptation were measured at the start of the study, after 6 months and after 12 months. Plasma lutein and zeaxanthin concentrations were assessed at baseline and at the end of the study. Results. In the lutein group, plasma lutein concentrations increased significantly from 205 ng/mL at baseline to 399 ng/mL after twelve months of intervention. MPOD increased significantly from 0.45 to 0.52 and BCVA improved significantly from −0.04 to −0.09 LogMar. Differences in rod dark adaptation rate between both groups were not significant. Conclusion. Daily consumption of a dairy drink containing lutein-enriched egg yolks for one year improves visual acuity, MPOD, and plasma lutein concentration in elderly subjects with drusen and/or retinal pigment epithelial abnormalities

    The pigs and “Old World peccaries” (Suidae and Palaeochoeridae, Suoidea, Artiodactyla) from the Miocene of Sandelzhausen (southern Germany): phylogeny and an updated classification of the Hyotheriinae and Palaeochoeridae

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