Exploring metabolic dysfunction in chronic kidney disease

Abstract Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturbances, including hypertension, dyslipidemia and the anorexia-cachexia syndrome which are linked to poor outcomes. Specific hormonal, inflammatory, and nutritional-metabolic factors may play key roles in CKD development and pathogenesis. These include raised proinflammatory cytokines, such as interleukin-1 and −6, tumor necrosis factor, altered hepatic acute phase proteins, including reduced albumin, increased C-reactive protein, and perturbations in normal anabolic hormone responses with reduced growth hormone-insulin-like growth factor-1 axis activity. Others include hyperactivation of the renin-angiotensin aldosterone system (RAAS), with angiotensin II and aldosterone implicated in hypertension and the promotion of insulin resistance, and subsequent pharmacological blockade shown to improve blood pressure, metabolic control and offer reno-protective effects. Abnormal adipocytokine levels including leptin and adiponectin may further promote the insulin resistant, and proinflammatory state in CKD. Ghrelin may be also implicated and controversial studies suggest activities may be reduced in human CKD, and may provide a rationale for administration of acyl-ghrelin. Poor vitamin D status has also been associated with patient outcome and CVD risk and may indicate a role for supplementation. Glucocorticoid activities traditionally known for their involvement in the pathogenesis of a number of disease states are increased and may be implicated in CKD-associated hypertension, insulin resistance, diabetes risk and cachexia, both directly and indirectly through effects on other systems including activation of the mineralcorticoid receptor. Insight into the multiple factors altered in CKD may provide useful information on disease pathogenesis, clinical assessment and treatment rationale such as potential pharmacological, nutritional and exercise therapies

A Radio Survey of Seven Southern X-ray Luminous Clusters of Galaxies

The Australia Telescope Compact Array (ATCA) has been used at 1.38 and 2.38 GHz to survey seven southern Abell clusters of galaxies with high X-ray luminosities: A2746, A2837, A3126, A3216, A3230, A3827 and A3836. The clusters have also been surveyed at 0.843 GHz with the Molonglo Observatory Synthesis Telescope (MOST). We have listed a complete 1.38-GHz sample of 149 radio sources within the Abell circles centred on their X-ray centroids. We compare their identification fractions, emitted 1.38-GHz and optical powers, radio spectral indices and radial variation in projected source density with those of the radio-selected samples of Slee et al. (1998). We compare our fractional radio luminosity function with that of the radio-selected samples of Ledlow and Owen (1996) and Slee et al. (1998). Three significant differences are noted between X-ray and radio-selected samples of clusters; (1) the X-ray sample has an excess of flat-spectrum radio sources; (2) the fractional radio luminosity function for the FR I sources in the X-ray selected sample is much steeper, implying that fewer of their cluster galaxies become hosts for the stronger FR I radio galaxies; (3) a complete absence of FR II radio galaxies in the X-ray selected sample. The average excess projected density of radio sources near our cluster centres is approx. 5 times the background source density.Comment: 24 pages, 8 figures, plus 6 figures to be published online only; accepted to appear in MNRA

Exploring hybridity in food supply chains

In recent years, a number of dynamic aspects of food supply chains have attracted great interest among social scientists investigating rural restructuring and change. These include: the expansion of organic agriculture; the development of new value added enterprises at farm level and the revitalisation of traditional and new-old artisanal production practices; the expansion from a low base of the market share of alternative short supply chains, such as farmers markets; and the so-called quality turn, riding on the heels of another turn in rural social research - the consumption turn. All of these changes come together in a vision of alternative agro food networks (AAFNs) that has been built around empirical and theoretical work from a number of predominantly European social researchers, centred on Wageningen, but conducted in a number of countries in Europe. These and other associated changes in the composition of farm-based economic activity are seen to be constitutive of a new paradigm of rural development comprising an alternative network of producers, consumers and other actors in relation to the mainstream agro-food system (Van der Ploeg et al. 2000; Van der Ploeg and Renting 2004; Renting et al. 2003). The theorisation surrounding this work on AAFNs has been sharply criticised by Goodman (2004). He challenges the vision of certain European social scientists of an alternative food sector rising like a phoenix from the ashes of the commodity-based food system to constitute a new paradigm of rural development. He notes their view of AAFNs as: innovative precursors of paradigm change, of a more endogenous, territorialized and ecologically embedded successor to the allegedly crisis-ridden modernisation model of conventional industrialised agriculture. (Goodman 2004:6) In particular, he challenges the binary categorisation into alternative and mainstream and is deeply sceptical as to the existence of a new paradigm while, at the same time, highly cognisant of dynamic changes within the agro-food sector. This paper is motivated by a desire to explore the extent to which different theories can help interpret and explain some of the most dynamic areas of agro-food systems that belong neither in the mainstream food supply chains and networks, nor in the alternative food supply networks. We review two areas where we argue that hybridity is evident in food supply chains and networks, and draw conclusions as to the research needs in a field where too often dualistic interpretations have prevailed.Agribusiness,

Jerwood Contemporary Makers 2010

Jerwood Contemporary Makers showcases work by the new generation of UK makers. Selected by Hans Stofer (chair), Richard Slee and myself, the exhibition investigates the notion of making by bringing together a broad range of work from across craft and the visual arts. Twenty-nine makers took part, each exhibiting one work and receiving an equal share of the £30,000 prize fund. Supported by the Jerwood Charitable Foundation. A catalogue in the form a newspaper broadsheet was produced with an essay, ‘The Making Game’ commissioned from Jeanette Winterson. A series of Monday evening events accompanied the exhibition. These included Emmanuel Cooper (ceramicist and craft writer) in conversation with Hans Stofer, Richard Slee and myself also a panel discussion exploring the notion of amateur making, chaired by Stephen Knott, (PhD student, School of Applied Art, RCA) with the research student that I supervise Emma Shercliff, (PhD student, School of Fashion & Textiles, RCA). At the National Craft Gallery, Kilkenny, Ireland I conducted a gallery tour and delivered a lecture and workshop on Curating Contemporary Craft alongside curator David Littler. The exhibition received considerable press including Crafts, July/August 2010 (Dr.Jessica Hemmings), Design Week, 27 May 2010 and The Independent, 29 June 2010 (Michael Glover)

Rural development policy and the provision of public goods: challenges for evaluation

Environmental “public goods” generated by agricultural land use are discussed in terms of their conceptual underpinnings and how they have been addressed to date in European Union policy for agriculture and rural development. The current debate on CAP reform has intensified the already considerable debate over how these goods should be valued, and how the relevant policy measures should be evaluated. Against this background, a number of methodological and practical issues for evaluation are discussed, including accounting for spatial scale and diversity, the estimation of use and non-use values, governance, potential conflict between “public goods” and their marketisation, and accounting for the marginal effects of rural development policy on environmental assets and their values.public goods, evaluation, Agricultural and Food Policy,

Using the PhotoStory method to understand the cultural context of youth victimisation in the Punjab

Bullying is an international issue that is only just beginning to be researched in India and anecdotal evidence in Punjab, India, has suggested that most schools in the Punjab are in denial about bullying on campus. Our aim was to investigate the nature of bullying in this region using the PhotoStory Method. We sought to discover how young people in India perceived and experienced incidents of bullying. Three Punjabi schools were issued with ipads that students could use to email the researchers their illustrated stories about bullying. Using the Pic Collage App, 33 students aged 12-15 sent PhotoStories about experiences of victimization. Many stories described incidents of physical harassment, name calling and ‘Eve teasing’, which left students feeling sad, embarrassed, depressed and helpless. However, only four PhotoStories described incidents that met the definition of bullying i.e. that involved repetitive, hurtful behaviour perpetrated by a person or persons that could be considered more ‘powerful’ than the victim. Nonetheless, the stories, while not lengthy and overly descriptive, did indicate that physical acts of aggression between peers were common in and outside school. The findings are discussed in relation to definitional issues and the need to implement anti-violence programs in Indian schools.peer-reviewe

‘Wild land’: a concept in search of space

This paper sets out the general background context surrounding the issue of wild land in Scotland. It explores definitions of wild land and related concepts, identifies key issues associated with wild land in Scotland, and explores the question of the desirability of designating areas as wild land for Scotland. There is increasing interest in the concept of ‘wild land’, ‘wildness’, or ‘wilderness’ in Scotland, other parts of the UK and Europe. Changes in agricultural policy are leading to land abandonment in several European Union member states and in some cases ‘re-wilding’ is taking place with little or no managerial input from humans. These events have led to renewed interest across Europe in setting aside land with minimal management to create ‘wild’ areas. There has been either interest or activity, not always in the public sector, in Italy, Spain, Germany, Austria and Switzerland, and the Netherlands in exploring and establishing some form of wild land area. Many of these are relatively small, with evidence of recent human activity, and, as such, are quite distinct from the concept of ‘wilderness’, which has been so influential in certain parts of the world (such as North America) in influencing the designation of areas of land for minimal management. In contrast there are the large areas of northern Scandinavia, which still contain ‘wilderness-like’ qualities, and to some extent are preserved in the wilderness areas and national parks of Finland, Sweden and Norway. Unfortunately, the terms ‘wild land’, ‘wildness’, ‘wilderness’, come with an enormous amount of associated cultural baggage, resulting in argument and conflict over definitions, purpose, and management of potential wild land or wilderness areas. The aim of this paper is to unpack some of that baggage and clarify the key issues in the current discussions on wild land taking place in Scotland

Whole-school mental health promotion in Australia

Although there is increasing recognition internationally of the significance of social and emotional health and wellbeing for the healthy development of young people, the levels of support that governments provide for mental health policy and programme initiatives vary widely. In this paper, consideration is given to Australia’s approach to mental health promotion from early years to secondary school, including specific reference to the KidsMatter Primary mental health promotion, prevention and early intervention initiative. Although it is now well established that schools provide important settings for the promotion of mental health initiatives, there are significant challenges faced in effectively implementing and maintaining the delivery of evidence-based practice in school settings, including concerns about quality assurance in processes of implementation, translation, dissemination and evaluation.peer-reviewe

Venturing into schools : locating mental health initiatives in complex environments

Schools provide viable settings for mental health promotion initiatives, such as programs to develop students’ social and emotional capabilities (SEC). Complexity in the school environments into which initiatives are introduced, such as diverse student capabilities, school structures, and teachers’ knowledge and confidence, will play an integral role in the success of those initiatives. This paper investigates the environments of schools about to receive the KidsMatter mental heath promotion, prevention and early intervention initiative in Australia, using information sourced from questionnaires about 2598 students and their teachers in 50 Australian primary schools. The focus of the report is on the status of the schools’ work in one of the key focus areas for the intervention, namely students’ SEC. Analysis showed relatively high levels of students’ SEC across the whole sample, but with sub-group differences. Teachers’ attitudes towards SEC learning were highly positive. Teachers’ self-rated knowledge and approaches in dealing with SEC were moderate, and point to requirements for additional pre-service and professional development. The extent of regular and sustained delivery of SEC programs and mental health initiatives in general showed variability, suggesting the need to attend to school systems and structural supports. Implications of these areas of diversity in school environments on the selection and methods of delivery of mental health promotion programs in schools are discussed.peer-reviewe