140 research outputs found

    The effect of parent interaction on pre-reaching infants’ visual attention during an object manipulation task.

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    Infants do not begin intentionally reaching for and grasping objects until around 5 months of age. The sticky mittens paradigm (SM) provides infants the opportunity to manipulate and explore objects on their own. Active SM experience has been shown to lead to positive cognitive outcomes (Libertus & Needham, 2010), including facilitating causal perception (Rakison & Krogh, 2012). While some aspects of SM that contribute to positive outcomes are well understood (e.g., active vs. passive experience), the role of parent interactions has received little attention. In this study, SM training was used to investigate the role that parents play in their infants’ learning during SM. Holt (2016) studied the effects of active vs. passive experience and parent encouragement vs. no parent encouragement on pre-reaching infants’ learning using SM. Holt (2016) found that infants in the active/no encouragement condition exhibited causal perception following SM experience, while infants in the other conditions, including the active/encouragement condition, did not. The present study is a secondary video analysis of Holt (2016), comparing infants’ visual attention and parents’ behaviors during the SM session in the active conditions. Given the findings of Holt (2016), we hypothesized that parent interactions have a negative effect on infant attention to objects during SM, which is necessary for infants’ learning. However, no difference was found between the two conditions for average bout duration on task or for proportion of clean attention. These findings suggest other aspects of parent interactions during SM might affect infants’ learning, which future research should investigate

    Improving Water Quality Through BMPs For Crop Production Systems Whole Farm Soil and Water Management

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    The major objective of this demonstration project was to assess the usefulness of Global Positioning Systems/Geographic Information Systems (GPS/GIS), water testing, soil testing and yield monitoring in a whole farm water and soil management plan. An important part of this objective was to make recommendations to increase crop productivity and decrease the potential for surface water degradation through erosion and runoff at the farm. The farm was located on 2400 acres in the Bayou de View watershed in Monroe County, Arkansas. The farm lies approximately five miles southwest of the town of Brinkley straddling Highway 17 just south of its intersection with County Road 302 and with U. S. Highway 70. Slightly over 2200 acres were under cultivation and this was generally in a 1 :2 ratio of rice to soybeans, with approximately half of the soybean fields double-cropped with winter wheat each year

    Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma

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    Since it has been widely recognised that renal cell carcinoma is refractory to standard therapies such as chemotherapy and radiotherapy, a new modality of treatment is needed. One of the potential alternative therapies for renal cell carcinoma may be inhibition of angiogenesis. In this study, we analysed the inhibitory effects of several potential agents on expression of angiogenic factors such as vascular endothelial growth factor and basic fibroblast growth factor, which are the main mediators in angiogenesis of renal cell carcinoma. We used medroxyprogesterone acetate, interferon-alpha, interferon-gamma, minocycline hydrochrolide and genistein, which are known to be antiangiogeneic. Northern blot analyses revealed that, among the five agents examined, genistein had a strong inhibitory effect on expression of vascular endothelial growth factor mRNA and basic fibroblast growth factor mRNA. Medroxyprogesterone acetate and interferon-alpha did not significantly decrease the level of either vascular endothelial growth factor mRNA or basic fibroblast growth factor mRNA. Interferon-gamma and minocycline had mild inhibitory effects on vascular endothelial growth factor mRNA and basic fibroblast growth factor mRNA expression. Genistein also inhibited both vascular endothelial growth factor mRNA and basic fibroblast growth factor mRNA expression after treatment with epidermal growth factor and hypoxia. These findings suggest that one of the mechanisms of the inhibition of angiogenesis by genistein is suppression of the expression of the angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor in renal cell carcinoma

    Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours

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    To evaluate the toxicity, pharmacological and biological properties of ATN-161, a five –amino-acid peptide derived from the synergy region of fibronectin, adult patients with advanced solid tumours were enrolled in eight sequential dose cohorts (0.1–16 mg kg−1), receiving ATN-161 administered as a 10-min infusion thrice weekly. Pharmacokinetic sampling of blood and urine over 7 h was performed on Day 1. Twenty-six patients received from 1 to 14 4-week cycles of treatment. The total number of cycles administered to all patients was 86, without dose-limiting toxicities. At dose levels above 0.5 mg kg−1, mean total clearance and volume of distribution showed dose-independent pharmacokinetics (PKs). At 8.0 and 16.0 mg kg−1, clearance of ATN-161 was reduced, suggesting saturable PKs. Dose escalation was halted at 16 mg kg−1 when drug exposure (area under the curve) exceeded that associated with efficacy in animal models. There were no objective responses. Six patients received more than four cycles of treatment (>112 days). Three patients received 10 or more cycles (⩾280 days). ATN-161 was well tolerated at all dose levels. Approximately, 1/3 of the patients in the study manifested prolonged stable disease. These findings suggest that ATN-161 should be investigated further as an antiangiogenic and antimetastatic cancer agent alone or with chemotherapy

    Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

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    <p>Abstract</p> <p>Background</p> <p>Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN) may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC) or squamous cell skin carcinomas (SCSC).</p> <p>Methods</p> <p>Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor.</p> <p>Results</p> <p>Sixteen elder (median 70 years-old) patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination), 40% PR (>30% tumor reduction), and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated.</p> <p>Conclusion</p> <p>The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials.</p> <p>Trial registration</p> <p>Current Controlled Trials RPCEC00000052.</p

    Intra-tumoural microvessel density in human solid tumours

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    Over the last decade assessment of angiogenesis has emerged as a potentially useful biological prognostic and predictive factor in human solid tumours. With the development of highly specific endothelial markers that can be assessed in histological archival specimens, several quantitative studies have been performed in various solid tumours. The majority of published studies have shown a positive correlation between intra-tumoural microvessel density, a measure of tumour angiogenesis, and prognosis in solid tumours. A minority of studies have not demonstrated an association and this may be attributed to significant differences in the methodologies employed for sample selection, immunostaining techniques, vessel counting and statistical analysis, although a number of biological differences may account for the discrepancy. In this review we evaluate the quantification of angiogenesis by immunohistochemistry, the relationship between tumour vascularity and metastasis, and the clinicopathological studies correlating intra-tumoral microvessel density with prognosis and response to anti-cancer therapy. In view of the extensive nature of this retrospective body of data, comparative studies are needed to identify the optimum technique and endothelial antigens (activated or pan-endothelial antigens) but subsequently prospective studies that allocate treatment on the basis of microvessel density are required

    PPARα Deficiency in Inflammatory Cells Suppresses Tumor Growth

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    Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)α is a central transcriptional suppressor of inflammation, and may therefore modulate tumor growth. Here we show that PPARα deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth. Bone marrow transplantation and granulocyte depletion show that PPARα expressing granulocytes are necessary for tumor growth. Neutralization of thrombospondin-1 restores tumor growth in PPARα-deficient mice. These findings suggest that the absence of PPARα activity renders inflammatory infiltrates tumor suppressive and, thus, may provide a target for inhibiting tumor growth by modulating stromal processes, such as angiogenesis

    Concrete governmentality: shelters and the transformations of preparedness

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    This article analyses how shelters act as a form of concrete governmentality. Shelters, like other forms of preparedness, are political acts in the absence of a disaster. They are materializations and visualizations of risk calculations. Shelters as a type of concrete governmentality pose the question of how to build something that lasts and resists, and remains relevant both when the object that is being resisted keeps changing and when the very act of building intervenes so publically in the life of the restless surrounding population. Comparing shelters in India, Switzerland and the UK, we highlight three transformations of preparedness that shelters trigger. First we analyse how shelters compose preparedness by changing the relationship between the state and its citizens. Rather than simply limiting risk or introducing “safety”, the building of shelters poses questions about who needs protection and why and, as we will show, this can generate controversy. Second, we analyse how shelters decompose preparedness by falling out of use. Third, we focus on struggles to recompose preparedness: Changing ideas about disasters thus lead to shelters being suddenly out of place, or needing to adapt
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