AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

published_or_final_versio

Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells

published_or_final_versio

AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

published_or_final_versio

Neuro-endovascular service in The University of Hong Kong Shenzhen Hospital

Conference Theme: Brain Attack: A New EraOral Poster Presentation I: paper no. FP1-03BACKGROUND: The University Hong Kong Shenzhen Hospital (HKU-SZH) is a newly established hospital and its neuroscience unit is affiliated with Queen Mary Hospital in Hong Kong. Its establishment in 2012 was part of a pilot scheme in healthcare reform in Mainland China. Acute stroke is an emerging healthcare burden in the aging population in China. In the management of acute stroke, endovascular intervention plays an important role; in particular for ...postprin

On Horava-Lifshitz "Black Holes"

The most general spherically symmetric solution with zero shift is found in the non-projectable Horava-Lifshitz class of theories with general coupling constants. It contains as special cases, spherically symmetric solutions found by other authors earlier. It is found that the generic solution has conventional (AdS, dS or flat) asymptotics with a universal 1/r tail. There are several special cases where the asymptotics differ, including the detailed balance choice of couplings. The conventional thermodynamics of this general class of solutions is established by calculating the energy, temperature and entropy. Although several of the solutions have conventional horizons, for particles with ultra-luminal dispersion relations such solutions appear to be horizonless.Comment: Latex 41 pages, 5 figure

A new method for grain refinement in magnesium alloy: High speed extrusion machining

Magnesium alloys have received broad attentions in industry due to their competitive strength to density ratio, but the poor ductility and strength limit their wide range of applications as engineering materials. A novel severe plastic deformation (SPD) technique of high speed extrusion machining (HSEM) was used here. This method could improve the aforementioned disadvantages of magnesium alloys by one single processing step. In this work, systematic HSEM experiments with different chip thickness ratios were conducted for magnesium alloy AZ31B. The microstructure of the chips reveals that HSEM is an effective SPD method for attaining magnesium alloys with different grain sizes and textures. The magnesium alloy with bimodal grain size distribution has increased mechanical properties than initial sample. The electron backscatter diffraction (EBSD) analysis shows that the dynamic recrystallization (DRX) affects the grain refinement and resulting hardness in AZ31B. Based on the experimental observations, a new theoretical model is put forward to describe the effect of DRX on materials during HSEM. Compared with the experimental measurements, the theoretical model is effective to predict the mechanical property of materials after HSEM. (c) 2015 Elsevier B.V. All rights reserved

Immersive learning of biomolecules

This paper reports a new international initiative on the use of virtual and augmented reality (VAR) technology to assist student learning of biomolecules. Researchers, developers and educators from Nanyang Technological University, National Institute of Education, Hwa Chong Institution and River Valley High School in Singapore, Utrecht University and Windesheim University of Applied Science in The Netherlands, will work together for two years on this project. The objective of this research is to investigate the benefits of applying the latest VAR technology to enhance students’ learning of molecular biology. In particular, the project is keen to design new immersive and interactive contents for selected topics such as enzymes, proteins, DNAs etc., in molecular biology. This interdisciplinary collaboration has a potential to grow globally

Virtual signatures of dark sectors in Higgs couplings

Where collider searches for resonant invisible particles loose steam, dark sectors might leave their trace as virtual effects in precision observables. Here we explore this option in the framework of Higgs portal models, where a sector of dark fermions interacts with the standard model through a strong renormalizable coupling to the Higgs boson. We show that precise measurements of Higgs-gauge and triple Higgs interactions can probe dark fermions up to the TeV scale through virtual corrections. Observation prospects at the LHC and future lepton colliders are discussed for the so-called singlet-doublet model of Majorana fermions, a generalization of the bino-higgsino scenario in supersymmetry. We advocate a two-fold search strategy for dark sectors through direct and indirect observables.Comment: 20 pages, 7 figures, 1 tabl