The study of effects on serum glucose, total lipid, total protein and albumin levels of orally zinc in rats

Objective: Zinc is an essential trace element, its metabolic roles are not known exactly. For this reason, we purposed to investigate the effects of zinc on the metabolism of lipid, carbohydrate and protein in our study. Material and methods: Hundred male Wistar albino rats were used in this study. After the adaptation period, rats were divided into 5 equal groups. Experimental period was 22 days. Feed and water were given ad libitum. Zero ppm, 100 ppm, 500 ppm. 1000 ppm and 2000 ppm zinc were given orally by nasogastric probe to control, experiment 1, experiment 2, experiment 3 and experiment 4 groups, respectively, in days 1, 6, 11, 16 and 21 of experimental period. Blood samples were taken on days 2, 7, 12, 17, 22 of experimental period. Serum glucose, total lipid, cholesterol, total protein and albumin levels in sera were determined by spectrophotometric methods. Results: At the end of the experimental period, all the parameters did not significantly increase in experimental groups. Conclusion: Our results suggest that high doses of zinc decreases serum glucose levels, but increases total lipid, total protein and albumin rates. Further studies are needed to explain the metabolic functions of this element

The effect of zinc on body weight and some serum enzymes in rats

100 male Wistar albino rats were used in this study. After the adaptation period, the rats were divided into 5 equal groups. The experimental period lasted 22 days. Food and water were given ad libitum. 0 ppm. 100 ppm, 500 ppm, 1,000 ppm and 2,000 ppm zinc were given by nasogastric probe to the control, experiment-1, experiment-2, experiment-3 and experiment-4 groups respectively, on days 1, 6, 11, 16, and 21 of the experimental period. The animals were weighed and blood samples were taken on days 2, 7, 12, 17, 22 of the experimental period. AST, ALT and ALP levels in sera were determined by spectrophotometric methods

The effects on metabolism of silicon in broilers

The aim of this study was to investigate the effects of silicon on body weights and metabolisms of broilers. Therefore, day-old 30 broiler chicks were parted to 2 groups (15 control group and 15 experimental group). The broilers in control group were fed with the normal (without supplement) broiler diet, but the diet of broilers in experimental group was composed with supplementation of 300 mg/kg silicon as sodium metasilicate. All of the animals were fed ad libitum for 40 days

The study of effects on metabolism of dietary aluminum in broilers

The aim of this study was to investigate the effects on metabolism and body weight of aluminum added to ration of broilers. Day-old thirty broiler chicks were divided into two equal groups and fed for 40 days. The broilers in experimental group were fed with dietary supplementation of 2 g/kg aluminum as aluminum sulfate and broilers in control group were fed with supplementary dietary sodium sulfate containing sulfate equal to those supplied by aluminum sulfate in diet of experimental group. In days 20 to 40 of experimental period, the broilers were weighed, and blood samples were taken with vacutainer tubes. In obtained sera, ALP, CK, gamma-GT, total and direct bilirubin, albumin, Ca, Pi, glucose, triglyceride, cholesterol, uric acid analyses were done spectrophotometrically

The accumulation levels in some tissues and the effect on lipid fractions in liver of dietary aluminum in broilers

In this study, the accumulation levels in serum, muscle and bone and the effect on lipid fractions in liver of dietary aluminum in broilers were examined

Preparation and in-vivo

Dimenhydrinate (DMH)-loaded buccal bioadhesive films for the prevention and treatment of motion sickness were prepared and optimized. This study examines the rate of drug release from the films for prolonged periods of time to reduce or limit the frequency of DMH administration. Based on preliminary studies using various polymers and concentrations, hydroxyethylcellulose (2.5, 3.0, and 3.2%), and xanthan gum (2.8%) were chosen as matrix polymers. The films were analyzed with respect to their mechanical, physicochemical, bioadhesive, swelling, and in-vitro release properties. In in-vivo pharmacokinetic studies, xanthan gum-based DMH buccal film was associated with significantly increased DMH plasma levels between 1 h and 5 h after DMH dosing when compared with an oral drug solution. The area under the curve AUC(0-7 h) value of the mucoadhesive buccal film was two-fold higher than the oral DMH solution. Histological analysis revealed that DMH films cause mild morphological and inflammatory changes in rabbit buccal mucosa. The DMH buccal film is effective for approximately 7 h, thus representing an option for single-dose antiemetic therapy. This dosage regimen could be particularly beneficial for chain travelers who travel for long periods of time