The prospects of measuring the angular power spectrum of the diffuse Galactic synchrotron emission with SKA1 Low

The diffuse Galactic synchrotron emission (DGSE) is the most important diffuse foreground component for future cosmological 21-cm observations. The DGSE is also an important probe of the cosmic ray electron and magnetic field distributions in the turbulent interstellar medium (ISM) of our Galaxy. In this paper we briefly review the Tapered Gridded Estimator (TGE) which can be used to quantify the angular power spectrum of the sky signal directly from the visibilities measured in radio-interferometric observations. The salient features of the TGE are (1.) it deals with the gridded data which makes it computationally very fast (2.) it avoids a positive noise bias which normally arises from the system noise inherent to the visibility data, and (3.) it allows us to taper the sky response and thereby suppresses the contribution from unsubtracted point sources in the outer parts and the sidelobes of the antenna beam pattern. We also summarize earlier work where the TGE was used to measure the C_l of the DGSE using 150 MHz GMRT data. Earlier measurements of the angular power spectrum are restricted to smaller angular multipole l ~ 10^3 for the DGSE, the signal at the larger l values is dominated by the residual point sources after source subtraction. The higher sensitivity of the upcoming SKA1 Low will allow the point sources to be subtracted to a fainter level than possible with existing telescopes. We predict that it will be possible to measure the angular power spectrum of the DGSE to larger values of l with SKA1 Low. Our results show that it should be possible to achieve l_{max} ~ 10^4 and ~ 10^5 with 2 minutes and 10 hours of observations respectively.Comment: 10 pages, 3 figures; Accepted for publication in Journal of Astrophysics and Astronomy (JOAA) special issue on "Science with the SKA: an Indian perspective

The visibility based Tapered Gridded Estimator (TGE) for the redshifted 21-cm power spectrum

We present the improved visibility based Tapered Gridded Estimator (TGE) for the power spectrum of the diffuse sky signal. The visibilities are gridded to reduce the computation, and tapered through a convolution to suppress the contribution from the outer regions of the telescope's field of view. The TGE also internally estimates the noise bias, and subtracts this out to give an unbiased estimate of the power spectrum. An earlier version of the 2D TGE for the angular power spectrum $C_{\ell}$ is improved and then extended to obtain the 3D TGE for the power spectrum $P({\bf k})$ of the 21-cm brightness temperature fluctuations. Analytic formulas are also presented for predicting the variance of the binned power spectrum. The estimator and its variance predictions are validated using simulations of $150 \, {\rm MHz}$ GMRT observations. We find that the estimator accurately recovers the input model for the 1D Spherical Power Spectrum $P(k)$ and the 2D Cylindrical Power Spectrum $P(k_\perp,k_\parallel)$, and the predicted variance is also in reasonably good agreement with the simulations.Comment: 19 pages, 13 figures. Accepted for publication in MNRAS. The definitive version will be available at http://mnrasl.oxfordjournals.org

Validating a novel angular power spectrum estimator using simulated low frequency radio-interferometric data

The "Tapered Gridded Estimator" (TGE) is a novel way to directly estimate the angular power spectrum from radio-interferometric visibility data that reduces the computation by efficiently gridding the data, consistently removes the noise bias, and suppresses the foreground contamination to a large extent by tapering the primary beam response through an appropriate convolution in the visibility domain. Here we demonstrate the effectiveness of TGE in recovering the diffuse emission power spectrum through numerical simulations. We present details of the simulation used to generate low frequency visibility data for sky model with extragalactic compact radio sources and diffuse Galactic synchrotron emission. We then use different imaging strategies to identify the most effective option of point source subtraction and to study the underlying diffuse emission. Finally, we apply TGE to the residual data to measure the angular power spectrum, and assess the impact of incomplete point source subtraction in recovering the input power spectrum $C_{\ell}$ of the synchrotron emission. This estimator is found to successfully recovers the $C_{\ell}$ of input model from the residual visibility data. These results are relevant for measuring the diffuse emission like the Galactic synchrotron emission. It is also an important step towards characterizing and removing both diffuse and compact foreground emission in order to detect the redshifted $21\, {\rm cm}$ signal from the Epoch of Reionization.Comment: 18 pages, 1 table, 9 figures, Accepted for publication in New Astronom

All-sky angular power spectrum – I. Estimating brightness temperature fluctuations using the 150-MHz TGSS survey

Measurements of the Galactic synchrotron emission are important for the 21-cm studies of the epoch of reionization. The study of synchrotron emission is also useful for quantifying the fluctuations in the magnetic field and the cosmic-ray electron density of the turbulent interstellar medium (ISM) of our Galaxy. Here, we present the all-sky angular power spectrum (Cℓ) measurements of the diffuse synchrotron emission obtained using the TIFR GMRT Sky Survey (TGSS) at 150 MHz

Towards 21-cm Intensity Mapping at z=2.28z=2.28 with uGMRT using the Tapered Gridded Estimator I: Foreground Avoidance

The post-reionization $(z \le 6)$ neutral hydrogen (HI) 21-cm intensity mapping signal holds the potential to probe the large scale structures, study the expansion history and constrain various cosmological parameters. Here we apply the Tapered Gridded Estimator (TGE) to estimate $P(k_{\perp},k_{\parallel})$ the power spectrum of the $z = 2.28$ $(432.8\, {\rm MHz})$ redshifted 21-cm signal using a $24.4\,{\rm MHz}$ sub-band drawn from uGMRT Band 3 observations of European Large-Area ISO Survey-North 1 (ELAIS-N1). The TGE allows us to taper the sky response which suppresses the foreground contribution from sources in the periphery of the telescope's field of view. We apply the TGE on the measured visibility data to estimate the multi-frequency angular power spectrum (MAPS) $C_{\ell}(\Delta\nu)$ from which we determine $P(k_{\perp},k_{\parallel})$ using maximum-likelihood which naturally overcomes the issue of missing frequency channels (55 \% here). The entire methodology is validated using simulations. For the data, using the foreground avoidance technique, we obtain a $2\,\sigma$ upper limit of $\Delta^2(k) \le (133.97)^2 \, {\rm mK}^{2}$ for the 21-cm brightness temperature fluctuation at $k = 0.347 \, \textrm{Mpc}^{-1}$. This corresponds to $[\Omega_{\rm HI}b_{\rm HI}] \le 0.23$, where $\Omega_{\rm HI}$ and $b_{\rm HI}$ respectively denote the cosmic \HI mass density and the \HI bias parameter. A previous work has analyzed $8 \, {\rm MHz}$ of the same data at $z=2.19$, and reported $\Delta^{2}(k) \le (61.49)^{2} \, {\rm mK}^{2}$ and $[\Omega_{\rm HI} b_{\rm HI}] \le 0.11$ at $k=1 \, {\rm Mpc}^{-1}$. The upper limits presented here are still orders of magnitude larger than the expected signal corresponding to $\Omega_{\rm HI} \sim 10^{-3}$ and $b_{\rm HI} \sim 2$.Comment: 13 pages, 11 figures, accepted for publication in MNRA

Towards 2121-cm intensity mapping at z=2.28z=2.28 with uGMRT using the tapered gridded estimator III: Foreground removal

Neutral hydrogen (\ion{H}{i}) $21$-cm intensity mapping (IM) is a promising probe of the large-scale structures in the Universe. However, a few orders of magnitude brighter foregrounds obscure the IM signal. Here we use the Tapered Gridded Estimator (TGE) to estimate the multi-frequency angular power spectrum (MAPS) $C_{\ell}(\Delta\nu)$ from a $24.4\,\rm{MHz}$ bandwidth uGMRT Band $3$ data at $432.8\,\rm{MHz}$. In $C_{\ell}(\Delta\nu)$ foregrounds remain correlated across the entire $\Delta\nu$ range, whereas the $21$-cm signal is localized within $\Delta\nu\le[\Delta \nu]$ (typically $0.5-1\,\rm{MHz}$). Assuming the range $\Delta\nu>[\Delta \nu]$ to have minimal $21$-cm signal, we use $C_{\ell}(\Delta\nu)$ in this range to model the foregrounds. This foreground model is extrapolated to $\Delta\nu\leq[\Delta \nu]$, and subtracted from the measured $C_{\ell}(\Delta\nu)$. The residual $[C_{\ell}(\Delta\nu)]_{\rm res}$ in the range $\Delta\nu\le[\Delta\nu]$ is used to constrain the $21$-cm signal, compensating for the signal loss from foreground subtraction. $[C_{\ell}(\Delta\nu)]_{\rm{res}}$ is found to be noise-dominated without any trace of foregrounds. Using $[C_{\ell}(\Delta\nu)]_{\rm res}$ we constrain the $21$-cm brightness temperature fluctuations $\Delta^2(k)$, and obtain the $2\sigma$ upper limit $\Delta_{\rm UL}^2(k)\leq(18.07)^2\,\rm{mK^2}$ at $k=0.247\,\rm{Mpc}^{-1}$. We further obtain the $2\sigma$ upper limit [\Omega_{\ion{H}{i}}b_{\ion{H}{i}}]_{\rm UL}\leq0.022 where \Omega_{\ion{H}{i}} and b_{\ion{H}{i}} are the comoving \ion{H}{i} density and bias parameters respectively. Although the upper limit is nearly $10$ times larger than the expected $21$-cm signal, it is $3$ times tighter over previous works using foreground avoidance on the same data.Comment: Accepted for publication in MNRAS. 16 pages (including Appendix), 8 figures (plus 8 in Appendix), 5 Table

Towards 2121-cm intensity mapping at z=2.28z=2.28 with uGMRT using the tapered gridded estimator -- IV. Wideband analysis

We present a Wideband Tapered Gridded Estimator (TGE), which incorporates baseline migration and variation of the primary beam pattern for neutral hydrogen (${\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}$) 21-cm intensity mapping (IM) with large frequency bandwidth radio-interferometric observations. Here we have analysed $394-494 \, {\rm MHz}$ $(z = 1.9 - 2.6)$ uGMRT data to estimate the Multi-frequency Angular Power Spectrum (MAPS) $C_\ell(\Delta\nu)$ from which we have removed the foregrounds using the polynomial fitting (PF) and Gaussian Process Regression (GPR) methods developed in our earlier work. Using the residual $C_\ell(\Delta\nu)$ to estimate the mean squared 21-cm brightness temperature fluctuation $\Delta^2(k)$, we find that this is consistent with $0 \pm 2 \sigma$ in several $k$ bins. The resulting $2\sigma$ upper limit $\Delta^2(k) < (4.68)^2 \, \rm{mK^2}$ at $k=0.219\,\rm{Mpc^{-1}}$ is nearly $15$ times tighter than earlier limits obtained from a smaller bandwidth ($24.4 \, {\rm MHz}$) of the same data. The $2\sigma$ upper limit $[\Omega_{{\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}} b_{{\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}}] < 1.01 \times 10^{-2}$ is within an order of magnitude of the value expected from independent estimates of the ${\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}$ mass density $\Omega_{{\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}}$ and the ${\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}$ bias $b_{{\rm H\hspace{0.5mm}}{\scriptsize {\rm I}}}$. The techniques used here can be applied to other telescopes and frequencies, including $\sim 150 \, {\rm MHz}$ Epoch of Reionization observations.Comment: Accepted for publication in MNRA

A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo

BACKGROUND: In search of a suitable GSH-depleting agent, a novel copper complex viz., copper N-(2-hydroxyacetophenone) glycinate (CuNG) has been synthesized, which was initially found to be a potential resistance modifying agent and later found to be an immunomodulator in mice model in different doses. The objective of the present work was to decipher the effect of CuNG on reactive oxygen species (ROS) generation and antioxidant enzymes in normal and doxorubicin-resistant Ehrlich ascites carcinoma (EAC/Dox)-bearing Swiss albino mice. METHODS: The effect of CuNG has been studied on ROS generation, multidrug resistance-associated protein1 (MRP1) expression and on activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). RESULTS: CuNG increased ROS generation and reduced MRP1 expression in EAC/Dox cells while only temporarily depleted glutathione (GSH) within 2 h in heart, kidney, liver and lung of EAC/Dox bearing mice, which were restored within 24 h. The level of liver Cu was observed to be inversely proportional to the level of GSH. Moreover, CuNG modulated SOD, CAT and GPx in different organs and thereby reduced oxidative stress. Thus nontoxic dose of CuNG may be utilized to reduce MRP1 expression and thus sensitize EAC/Dox cells to standard chemotherapy. Moreover, CuNG modulated SOD, CAT and and GPx activities to reduce oxidative stress in some vital organs of EAC/Dox bearing mice. CuNG treatment also helped to recover liver and renal function in EAC/Dox bearing mice. CONCLUSION: Based on our studies, we conclude that CuNG may be a promising candidate to sensitize drug resistant cancers in the clinic

Convention AFME/LNE 1984. Rapport final. Etudes effectuees pour l'AFME

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