Lean Six Sigma for reducing student dropouts in higher education – an exploratory study

This paper investigates the potential causes behind student dropouts in higher education institutions (HEIs), and explores the use of Lean Six Sigma (LSS) tools in reducing dropout rates. This qualitative study used 12 semi-structured interviews with university employees (n = 9) and LSS experts (n = 3), in order to understand the complexity of the student dropout phenomenon and the role of various LSS tools in reducing the dropout rates. Analysis revealed that in order to develop a typology of student dropouts, HEIs have to maintain detailed records and sensitise relevant authorities about the impact of a student’s dropout decision. Though the small number of semi-structured interviews is a limitation of the study, the revelations of HEIs authorities and LSS experts have given new impetus to look at and take action on the issue of student dropouts in HEIs

Modulation of host cell processes by T3SS effectors

Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target-the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection