4 research outputs found
Combating unintentional injury in the United States: Lessons learned from the ICD-10 classification period
Adiponectin in relation to childhood myeloblastic leukaemia
Adiponectin, an adipocyte-specific secretory protein known to induce
apoptosis, has been reported to be inversely related to breast and
endometrial cancers and recently found to inhibit proliferation of
myeloid but not lymphoid cell lines. We hypothesised that adiponectin
may be inversely associated with acute myeloblastic leukaemia (AML), but
not with acute lymphoblastic leukaemia of B (ALL-B) or T (ALL-T) cell
origin in children. Blood samples and clinical information were
collected over the period 1996 - 2000 from 201 children (0 - 14 years
old) with leukaemia (22 AML, 161 ALL-B and 18 ALL-T cases) through a
national network of childhood Hematology-Oncology units in Greece and
from 201 controls hospitalised for minor pediatric ailments. Serum
adiponectin levels were measured under code, at the Beth Israel
Deaconess Medical Center, Boston, MA, USA using a radioimmunoassay
procedure. Each of the three leukaemia groups was compared with the
control group through multiple logistic regression. Odds ratios ( OR)
and 95% confidence intervals ( 95% CI) for an increase of adiponectin
equal to 1 s.d. among controls were estimated controlling for gender,
age, as well as for height and weight, expressed in age-gender-specific
centiles of Greek growth curves. Adiponectin was inversely associated
with AML (OR = 0.56; 95% CI, 0.34 - 0.94), whereas it was not
significantly associated with either ALL-B (OR = 0.88; 95% CI, 0.71 -
1.10) or ALL-T (OR = 1.08; 95% CI, 0.67 - 1.72). Biological
plausibility and empirical evidence point to the importance of this
hormone in the pathogenesis of childhood AML
Incidence and characteristics of childhood Hodgkin's lymphoma in Greece: a nationwide study (Greece)
Objectives To estimate the incidence and epidemiological profile of
childhood (0-14 years) Hodgkin’s lymphoma in Greece derived by the
network of childhood Hematology-Oncology departments on the basis of all
95 newly diagnosed cases during a seven-year period.
Methods Seventy-one of these cases were individually age and gender
matched to an equal number of controls.
Results The incidence of childhood Hodgkin Lymphoma reached a relatively
high figure of 7.8 per million children-years, with an age distribution
(2.2 for children 0-4; 6.3 for those 5-9 and 13.9 for those
10-14-years-old) and male to female ratio (1.7:1) similar to that
reported from other cancer registries. Childhood Hodgkin’s lymphoma was
more common among children living in less crowded quarters (odds ratio
(OR): 6.5 and 95% confidence intervals (95% CI): 1.4-30.7), among
those who have changed residence 60 to 18 months before the onset of the
index disease (OR: 4.4, and 95% CI = 1.4-14.0), among those whose
families owned a cat (OR: 5.5, 95% CI = 1.2-25.6) but not among those
whose families owned a dog and marginally more common, among those with
a history of infectious mononucleosis (OR: 5.0, 95% CI = 0.6-42.8).
Conclusions Our results point to infectious agent(s) as playing an
etiological role but do not allow discrimination among the delayed
establishment of the herd immunity hypothesis, the population mixing
hypothesis or that invoking transmission of the agent(s) from the
non-human reservoir