10 research outputs found
Reversible cardiopathy after accidental overdose of mitoxantrone
No full textMitoxantrone is an anthraquinone structurally related to the anthracycline drugs doxorubicin and daunorubicin. In animal tumor models, it was equally cytotoxic as but less cardiotoxic than the parent compounds. We here describe the clinical course of a 9-year old girl who inadvertently received 100 mg/m2 of mitoxantrone as a bolus injection. Hemoperfusion carried out twice with the-objective of increasing the drug clearance was totally inefficient. Severe but transient myelotoxicity was induced. Sequential echocardiograms demonstrated a reversible decrease of the shortening fraction of the left ventricle
High-pressure liquid Chromatographie determination of navelbine in MO4 mouse fibrosarcoma cells and biological fluids.
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Determination of vinca alcaloids in mouse tissues by high pressure liquid chromatography.In: J. Chromatography, 1992, 578, pp. 223-229.
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Accumulation of anthracenyl-amino acid topoisomerase I and II inhibitors in drug-sensitive and drug-resistant human ovarian cancer cell lines determined by high-performance liquid chromatography
No full textPhase I trial of mitoxantrone and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced solid malignancies
No full textPrevalence and management of anaemia in patients with non-myeloid cancer undergoing systemic therapy: a Spanish survey
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