6,984 research outputs found

    Simultaneous removal of NO and Hgā° using Fe and Co co-doped Mn-Ce/TiOā‚‚ catalysts

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    Fe and Co co-doped Mn-Ce/TiO2 (MCT) catalysts were investigated for the simultaneous removal of nitric oxide (NO) and elemental mercury (Hg0) at reaction temperature lower than 200 Ā°C. The catalysts were characterized by Brunauerā€“Emmettā€“Teller (BET), temperature program reduction (TPR), scanning electron microscope (SEM), x-ray diffraction (XRD) and x-ray photoelectron spectroscopy (XPS) analysis. The experimental results showed that the co-doped 2Fe4Co-MCT catalyst exhibited better performance for the simultaneous removal of NO and Hg0 compared to Fe or Co doped catalysts. This could be due to higher BET surface area and better redox property of 2Fe4Co-MCT catalyst. In addition, we propose that chemisorbed O2 played a dominant role in selective catalytic reduction (SCR) of NO while lattice O2 played a key role in Hg0 oxidation. The results also indicate that the introduction of Fe species enhanced the activity of SCR, whereas the introduction of Co species enhanced the oxidation of Hg0. The synergistic effect of Fe and Co species in the 2Fe4Co-MCT catalyst are also suggested to be an important mechanism for simultaneously removing NO and Hg0

    Fabrication of FeSe1-x superconducting films with bulk properties

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    We have fabricated high-quality FeSe1-x superconducting films with a bulk Tc of 11-12 K on different substrates, Al2O3(0001), SrTiO3(100), MgO(100), and LaAlO3(100), by using a pulsed laser deposition technique. All the films were grown at a high substrate temperature of 610 oC, and were preferentially oriented along the (101) direction, the latter being to be a key to fabricating of FeSe1-x superconducting thin films with high Tc. According to the energy dispersive spectroscopy data, the Fe:Se composition ratio was 1:0.90+-0.02. The FeSe1-x film grown on a SrTiO3 substrate showed the best quality with a high upper critical magnetic field [Hc2(0)] of 56 T

    Ki67 Antigen as a Predictive Factor for Prognosis of Sinonasal Mucosal Melanoma

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    ObjectivesSinonasal mucosal melanoma is a rare and aggressive disease. The aim of this study was to analyze the clinical features of patients with sinonasal mucosal melanoma and to determine the role of Ki67 antigen as a predictor of prognosis in sinonasal mucosal melanoma.MethodsThis was a retrospective case-series study at a single institution, an academic tertiary referral center. From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry.ResultsThe overall 5-yr survival rate was 33.9%. No significant differences were observed in 5-yr survival according to age, sex, stage, or the presence of melanin. The rates of local failure, regional failure, and distant failure were 37.0%, 14.8%, and 11.1%, respectively. Patients with spindle or mixed cell types had better prognoses than those with other cell types. At a cut-off value of 35%, patients with lower Ki67 scores showed better survival than those with higher Ki67 scores.ConclusionThe presence of spindle or mixed cell types may indicate a better prognosis than other cell types. Ki67 immunostaining may be a useful predictor of prognosis in patients with mucosal malignant melanoma of the sinonasal tract

    Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis

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    Background and Aims The ā€œgut homingā€ hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gutā€derived T cells to the liver. However, inconsistencies lie within this theory including an absence of investigations and comparisons with other chronic liver diseases (CLD). Here, we examine ā€œthe gut homing theoryā€ in patients with PSC with associated inflammatory bowel disease (PSCā€IBD) and across multiple inflammatory liver diseases. Approach and Results Expression of MAdCAMā€1, CCL25, and Eā€Cadherin were assessed histologically and using RTā€PCR on explanted liver tissue from patients with CLD undergoing OLT and in normal liver. Liver mononuclear cells were isolated from explanted tissue samples and the expression of gut homing integrins and cytokines on hepatic infiltrating gutā€derived T cells was assessed using flow cytometry. Hepatic expression of MAdCAMā€1, CCL25 and Eā€Cadherin was upā€regulated in all CLDs compared with normal liver. There were no differences between disease groups. Frequencies of Ī±4Ī²7, Ī±EĪ²7, CCR9, and GPR15 expressing hepatic T cells was increased in PSCā€IBD, but also in CLD controls, compared with normal liver. Ī²7 expressing hepatic T cells displayed an increased inflammatory phenotype compared with Ī²7 negative cells, although this inflammatory cytokine profile was present in both the inflamed and normal liver. Conclusions These findings refute the widely accepted ā€œgut homingā€ hypothesis as the primary driver of PSC and indicate that aberrant hepatic recruitment of gutā€derived T cells is not unique to PSC, but is a panetiological feature of CLD

    Performance deficits of NK1 receptor knockout mice in the 5 choice serial reaction time task: effects of d Amphetamine, stress and time of day.

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    Background The neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD). Here we tested whether NK1R-/- mice express other core features of ADHD (impulsivity and inattentiveness) and, if so, whether they are diminished by d-amphetamine, as in ADHD. Prompted by evidence that circadian rhythms are disrupted in ADHD, we also compared the performance of mice that were trained and tested in the morning or afternoon. Methods and Results The 5-Choice Serial Reaction-Time Task (5-CSRTT) was used to evaluate the cognitive performance of NK1R-/- mice and their wildtypes. After training, animals were tested using a long (LITI) and a variable (VITI) inter-trial interval: these tests were carried out with, and without, d-amphetamine pretreatment (0.3 or 1 mg/kg i.p.). NK1R-/- mice expressed greater omissions (inattentiveness), perseveration and premature responses (impulsivity) in the 5-CSRTT. In NK1R-/- mice, perseveration in the LITI was increased by injection-stress but reduced by d-amphetamine. Omissions by NK1R-/- mice in the VITI were unaffected by d-amphetamine, but premature responses were exacerbated by this psychostimulant. Omissions in the VITI were higher, overall, in the morning than the afternoon but, in the LITI, premature responses of NK1R-/- mice were higher in the afternoon than the morning. Conclusion In addition to locomotor hyperactivity, NK1R-/- mice express inattentiveness, perseveration and impulsivity in the 5-CSRTT, thereby matching core criteria for a model of ADHD. Because d-amphetamine reduced perseveration in NK1R-/- mice, this action does not require functional NK1R. However, the lack of any improvement of omissions and premature responses in NK1R-/- mice given d-amphetamine suggests that beneficial effects of this psychostimulant in other rodent models, and ADHD patients, need functional NK1R. Finally, our results reveal experimental variables (stimulus parameters, stress and time of day) that could influence translational studies

    Interaction Between Marginal Zinc and High Fat Supply on Lipid Metabolism and Growth of Weanling Rats

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    The impact of a moderate Zn deficiency on growth and plasma and liver lipids was investigated in two 4-week experiments with male weanling rats fed fat-enriched diets. Semisynthetic, approximately isocaloric diets containing 3% soybean oil were supplemented with either 7 or 100Ā mgĀ Zn/kg diet and with 22% beef tallow (BT) or sunflower oil (SF). In Experiment 1, which compared the dietary fat level and the fat source in a factorial design of treatments, all diets were fed ad libitum to 6Ā Ć—Ā 8 animals, whereas intake of the high-Zn BT and SF diets was restricted in Experiment 2 (5Ā Ć—Ā 6 rats) to the level of intake of the respective low-Zn diets. The low-Zn SF diet consistently depressed food intake and final live weights of the animals to a greater extent than the other low-Zn diets, while intake and growth were comparable among the animals fed the high-Zn diets. The marginal Zn deficit per se did not alter plasma triglyceride and cholesterol concentrations nor hepatic concentrations of triglyceride, cholesterol and phospholipids. The fatty acid pattern of liver phospholipids did not indicate that chain elongation and desaturation of fatty acids was impaired by a lack of zinc. It was concluded that dietary energy and fat intake, and fat source have a greater effect on plasma and liver lipids than a moderate Zn deficiency. Marginally Zn-deficient diets enriched with sunflower oil as a major energy source cause a greater growth retardation than diets rich in carbohydrates or beef tallow
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