Abstractness of human speech sound representations

We argue, based on a study of brain responses to speech sound differences in Japanese, that memory encoding of functional speech sounds-phonemes-are highly abstract. As an example, we provide evidence for a theory where the consonants/p t k b d g/ are not only made up of symbolic features but are underspecified with respect to voicing or laryngeal features, and that languages differ with respect to which feature value is underspecified. In a previous study we showed that voiced stops are underspecified in English [Hestvik, A., & Durvasula, K. (2016). Neurobiological evidence for voicing underspecification in English. Brain and Language], as shown by asymmetries in Mismatch Negativity responses to /t/ and /d/. In the current study, we test the prediction that the opposite asymmetry should be observed in Japanese, if voiceless stops are underspecified in that language. Our results confirm this prediction. This matches a linguistic architecture where phonemes are highly abstract and do not encode actual physical characteristics of the corresponding speech sounds, but rather different subsets of abstract distinctive features

Fast magnetic reconnection in free space: self-similar evolution process

We present a new model for time evolution of fast magnetic reconnection in free space, which is characterized by self-similarity. Reconnection triggered by locally enhanced resistivity assumed at the center of the current sheet can self-similarly and unlimitedly evolve until external factors affect the evolution. The possibility and stability of this type of evolution are verified by numerical simulations in a very wide spatial dynamic range. Actual astrophysical reconnection in solar flares and geomagnetospheric substorms can be treated as an evolutionary process in free space, because the resultant scale is much larger than the initial scale. In spite of this fact, most of the previous numerical works focused on the evolutionary characters strongly affected by artificial boundary conditions on the simulation boundary. Our new model clarifies a realistic evolution for such cases. The characteristic structure around the diffusion region is quite similar to the Petschek model which is characterized by a pair of slow-mode shocks and the fast-mode rarefaction-dominated inflow. However, in the outer region, a vortex-like return flow driven by the fast-mode compression caused by the piston effect of the plasmoid takes place. The entire reconnection system expands self-similarly.Comment: 17 Pages, 17 Figure

Automated Synthesis System for Production of [11C] Fatty Acid with Computer Control

開始ページ、終了ページ: 冊子体のページ付

Phenotypic Plasticity of Mouse Spermatogonial Stem Cells

BACKGROUND:Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in vitro SSC culture experiments indicated heterogeneity of cultured cells and suggested that they might not follow deterministic fate commitment in vitro. METHODOLOGY AND PRINCIPAL FINDINGS:In this study, we report phenotypic plasticity of SSCs. Although c-kit tyrosine kinase receptor (Kit) is not expressed in SSCs in vivo, it was upregulated when SSCs were cultured on laminin in vitro. Both Kit(-) and Kit(+) cells in culture showed comparable levels of SSC activity after germ cell transplantation. Unlike differentiating spermatogonia that depend on Kit for survival and proliferation, Kit expressed on SSCs did not play any role in SSC self-renewal. Moreover, Kit expression on SSCs changed dynamically once proliferation began after germ cell transplantation in vivo. CONCLUSIONS/SIGNIFICANCE:These results indicate that SSCs can change their phenotype according to their microenvironment and stochastically express Kit. Our results also suggest that activated and non-activated SSCs show distinct phenotypes

Liesegang patterns: Effect of dissociation of the invading electrolyte

The effect of dissociation of the invading electrolyte on the formation of Liesegang bands is investigated. We find, using organic compounds with known dissociation constants, that the spacing coefficient, 1+p, that characterizes the position of the n-th band as x_n ~ (1+p)^n, decreases with increasing dissociation constant, K_d. Theoretical arguments are developed to explain these experimental findings and to calculate explicitly the K_d dependence of 1+p.Comment: RevTex, 8 pages, 3 eps figure