Analysis and Development of Emergency Management Information System for Railway Systems in Taiwan

Railway is one of the most efficient, convenient, and comfortable ways with maximum mobility to meet people. Railway accidents or disasters often cause delays and service interruptions, resulting in operational and other loss. Despite many railway systems in Taiwan having a variety of monitoring systems for natural disasters, they still need an efficient platform for the emergency management of disasters and accidents since time and efficiency are the keys to emergency management. This study aims to fill in this gap by developing an emergency management information system for Railway Systems in Taiwan, i.e. “Railway Emergency Management Information System”, to support railway emergency management center and its sub-divisions in resource management, communication, messaging, and information sharing among different groups. The system includes many features that will improve communications between emergency management center and the mobile emergency management center to facilitate the progress of the disaster control units and dispatching at the disaster site. The study’s information system has been designated by local railway administration as the core system and starts trial since February 2012. Information requirement analysis, framework and design of the aforementioned information system will be discussed in this paper. It is hoped that the present study's information system research will help improve the emergency response of railway administration and provide safer rail transport service for the passengers

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings

Rapid and simple preparation of a reagentless glucose electrochemical biosensor

10.1039/c2an35128eAnalyst137163800-3805ANAL

Technology behind commercial devices for blood glucose monitoring in diabetes management: A review

10.1016/j.aca.2011.07.024Analytica Chimica Acta7032124-136ACAC

Mediatorless amperometric glucose biosensing using 3- aminopropyltriethoxysilane-functionalized graphene

10.1016/j.talanta.2012.05.014Talanta9922-28TLNT

Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of cisplatin

10.1016/j.carbon.2011.11.043Carbon5041625-1634CRBN