Bacteria herald a new era of gene editing.

The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome engineering

Beyond the genome and into the clinic.

A report of BioMed Central's third annual Beyond the Genome conference, held at Harvard Medical School, Boston, September 27-29, 2012

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

Transcription factor-DNA interactions are some of the most important processes in biology because they directly control hereditary information. The targets of most transcription factor are unknown. In this report, we introduce Bind-n-Seq, a new high-throughput method for analyzing protein-DNA interactions in vitro, with several advantages over current methods. The procedure has three steps (i) binding proteins to randomized oligonucleotide DNA targets, (ii) sequencing the bound oligonucleotide with massively parallel technology and (iii) finding motifs among the sequences. De novo binding motifs determined by this method for the DNA-binding domains of two well-characterized zinc-finger proteins were similar to those described previously. Furthermore, calculations of the relative affinity of the proteins for specific DNA sequences correlated significantly with previous studies (R(2 )= 0.9). These results present Bind-n-Seq as a highly rapid and parallel method for determining in vitro binding sites and relative affinities

Models of Civil-Military Relationships at the Elite Level

http://deepblue.lib.umich.edu/bitstream/2027.42/50840/1/58.pd

MacNews : an interactive news retrieval service for the Macintosh

Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1989.Includes bibliographical references (leaf 37).by David Andrew Segal.B.S

F as in Fat: How Obesity Threatens America's Future 2011

Outlines 2008-10 national and state obesity rates, health indicators, and policies to address the epidemic; regional, economic, and social barriers to healthy choices; impact of the 2010 healthcare reform and Let's Move initiative; and recommendations

Mass Society and Non-Linear Development: A Study in Communication and Political Integration

http://deepblue.lib.umich.edu/bitstream/2027.42/50827/1/43.pd