THE RESOURCES MANAGEMENT MOVEMENT (The Coming Death of Production Management Education)

Production management, taught in nearly all colleges of business administration, is not a popular course. One reason it is not popular is that it does not relate to the typical young student\u27s life experiences. This typical student has for 18 years or more been a social animal, and thus he can relate to college courses in the sociopsychological realm. The rare student who has considerable work experience is the only one likely to appreciate and perhaps even enjoy a course in production management (or operations management, as it is called in some schools). But this kind of problem is found in many fields: engineering, the physical sciences, foreign languages, etc. The instructor in such areas tends to shrug his shoulders and occasionally express the forlorn wish that more students would go to work for a few years before entering college

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone

Eyes Absents (EYA) are multifunctional proteins best known for their role in organogenesis. There is accumulating evidence that overexpression of EYAs in breast and ovarian cancers, and in malignant peripheral nerve sheath tumors, correlates with tumor growth and increased metastasis. The EYA protein is both a transcriptional activator and a tyrosine phosphatase, and the tyrosine phosphatase activity promotes single cell motility of mammary epithelial cells. Since EYAs are expressed in vascular endothelial cells and cell motility is a critical feature of angiogenesis we investigated the role of EYAs in this process. Using RNA interference techniques we show that EYA3 depletion in human umbilical vein endothelial cells inhibits transwell migration as well as Matrigel-induced tube formation. To specifically query the role of the EYA tyrosine phosphatase activity we employed a chemical biology approach. Through an experimental screen the uricosuric agents Benzbromarone and Benzarone were found to be potent EYA inhibitors, and Benzarone in particular exhibited selectivity towards EYA versus a representative classical protein tyrosine phosphatase, PTP1B. These compounds inhibit the motility of mammary epithelial cells over-expressing EYA2 as well as the motility of endothelial cells. Furthermore, they attenuate tubulogenesis in matrigel and sprouting angiogenesis in the ex vivo aortic ring assay in a dose-dependent fashion. The anti-angiogenic effect of the inhibitors was also demonstrated in vivo, as treatment of zebrafish embryos led to significant and dose-dependent defects in the developing vasculature. Taken together our results demonstrate that the EYA tyrosine phosphatase activity is pro-angiogenic and that Benzbromarone and Benzarone are attractive candidates for repurposing as drugs for the treatment of cancer metastasis, tumor angiogenesis, and vasculopathies

Big Data and Causality

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Causality analysis continues to remain one of the fundamental research questions and the ultimate objective for a tremendous amount of scientific studies. In line with the rapid progress of science and technology, the age of big data has significantly influenced the causality analysis on various disciplines especially for the last decade due to the fact that the complexity and difficulty on identifying causality among big data has dramatically increased. Data mining, the process of uncovering hidden information from big data is now an important tool for causality analysis, and has been extensively exploited by scholars around the world. The primary aim of this paper is to provide a concise review of the causality analysis in big data. To this end the paper reviews recent significant applications of data mining techniques in causality analysis covering a substantial quantity of research to date, presented in chronological order with an overview table of data mining applications in causality analysis domain as a reference directory

THE RESOURCES MANAGEMENT MOVEMENT (The Coming Death of Production Management Education)

Production management, taught in nearly all colleges of business administration, is not a popular course. One reason it is not popular is that it does not relate to the typical young student\u27s life experiences. This typical student has for 18 years or more been a social animal, and thus he can relate to college courses in the sociopsychological realm. The rare student who has considerable work experience is the only one likely to appreciate and perhaps even enjoy a course in production management (or operations management, as it is called in some schools). But this kind of problem is found in many fields: engineering, the physical sciences, foreign languages, etc. The instructor in such areas tends to shrug his shoulders and occasionally express the forlorn wish that more students would go to work for a few years before entering college

The Transfer of Japanese Manufacturing Management Approaches to U. S. Industry

Just-in-time (JIT) provisioning of manufacturing inventories is a notable feature of Japanese manufacturing management. Kawasaki Motors, USA, has committed itself to JIT objectives, which result in moving toward lotless repetitive manufacturing, a streamlined mode of operation characterized by minimal inventories and shop paper, plus flexible market response. Kawasaki USA has forged a hybrid process of effecting change, featuring Japanese JIT objectives but without Japanese-style consensus mechanisms for making decisions and effecting change

World class manufacturing : The next decade : Building Power, Strength, and Value

New Yorkxi, 266 p.; 24 c

Teknik-Teknik Manufaktur Jepang : Sembilan Pelajaran Sederhana Yang Tersembunyi

Jakartaiii, 191 hal.: ilus.; 24 c

Operations Management : Productivity and Quality

Texasxii, 778 p.: illus.; 24 c