4 research outputs found
INDUCTION ASYMETRIQUE EN MILIEU SUPRAMOLECULAIRE CHIRAL (REDUCTIONS HAUTEMENT ENANTIOSELECTIVES DE CETONES PROCHIRALES A L'INTERFACE DE DENDRIMERES GLYCOSYLES)
TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF
Highly active, entirely biobased antimicrobial Pickering emulsions
We present the development of surfactantâfree, silicaâfree and fully biobased oilâinâwater antimicrobial Pickering emulsions, based on the selfâassembly of b âcyclodextrin and phytoantimicrobial oils (terpinenâ4âol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bioâbased drug to treat fungal infection, but is less effective than petroleumâbased drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gramâpositive and Gramânegative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillinâresistant S. aureus (MRSA), compared to UA and azoleâbased commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans . Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmentalâfriendly emulsion
Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators
Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.Charitable Leadership FoundationMedical Technology Acceleration ProgramPharmaceutical Research Institut