31 research outputs found
Transplantation of Photoreceptor and Total Neural Retina Preserves Cone Function in P23H Rhodopsin Transgenic Rat
Background: Transplantation as a therapeutic strategy for inherited retinal degeneration has been historically viewed to restore vision as a method by replacing the lost retinal cells and attempting to reconstruct the neural circuitry with stem cells, progenitor cells and mature neural retinal cells. Methods and Findings: We present evidence for an alternative strategy aimed at preventing the secondary loss of cones, the most crucial photoreceptors for vision, by transplanting normal photoreceptors cells into the eye of the P23H rat, a model of dominant retinitis pigmentosa. We carried out transplantation of photoreceptors or total neural retina in 3-monthold P23H rats and evaluated the function and cell counts 6 months after surgery. In both groups, cone loss was significantly reduced (10%) in the transplanted eyes where the cone outer segments were found to be considerably longer. This morphological effect correlated with maintenance of the visual function of cones as scored by photopic ERG recording, but more precisely with an increase in the photopic b-wave amplitudes by 100 % and 78 % for photoreceptor transplantation and whole retinal transplantation respectively. Conclusions: We demonstrate here that the transplanted tissue prevents the loss of cone function, which is furthe
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ACTIVITY PATTERNS OF GULL CHICKS IN RELATION TO FEEDING BY PARENTS - THEIR POTENTIAL SIGNIFICANCE FOR DENSITY-DEPENDENT MORTALITY
Recommended from our members
ACTIVITY PATTERNS OF GULL CHICKS IN RELATION TO FEEDING BY PARENTS - THEIR POTENTIAL SIGNIFICANCE FOR DENSITY-DEPENDENT MORTALITY
ACTIVITY PATTERNS OF GULL CHICKS IN RELATION TO FEEDING BY PARENTS - THEIR POTENTIAL SIGNIFICANCE FOR DENSITY-DEPENDENT MORTALITY
Photograph taken by Salt Lake Tribune staf