Curcumin-loaded zeolite as anticancer drug carrier: Effect of curcumin adsorption on zeolite structure

In this work we used a combination of different techniques to investigate the adsorption properties of curcumin by zeolite type A for potential use as an anticancer drug carrier. Curcumin is a natural water-insoluble drug that has attracted great attention in recent years due to its potential anticancer effect in suppressing many types of cancers, while showing a synergistic antitumor effect with other anticancer agents. However, curcumin is poorly soluble in aqueous solutions leading to the application of high drug dosage in oral formulations. Zeolites, inorganic crystalline aluminosilicates with porous structure on the nano- and micro-scale and high internal surface area, can be useful as pharmaceutical carrier systems to encapsulate drugs with intrinsic low aqueous solubility and improve their dissolution. Here, we explore the use of zeolite type A for encapsulation of curcumin, and we investigate its surface properties and morphology, before and after loading of the anticancer agent, using scanning electron microscopy (SEM), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and UV-vis spectroscopy. Results are used to assess the loading efficiency of zeolite type A towards curcumin and its structural stability after loading

A VSA-SS Approach to Healthcare Service Systems. The Triple Target of Efficiency, Effectiveness and Sustainability

The main purpose of this paper is to highlight the new opportunities that the Viable Systems Approach (VSA) can provide for observing complex service systems and explaining social phenomena through general schemes of interpretation. At the same time, it explores methodological links with the Service Science (SS) approach in order to propose (VSA)’s contribution to moulding a unified vision of complex objects of analysis, and to evidence the many converging elements that emerge from the two perspectives as well as the benefits that derive from different interpretation schemes. In particular, in our paper we analyze healthcare service complexity in a relational perspective, using a VSA-SS conceptual framework to interpret the emergent systems instability in the Italian Health Service. The application of principles and concepts proper to the (VSA) and the SS approaches to articulated service structures, such as healthcare, identifies critical features and interesting new “therapeutic” prospects for healthcare service systems in order to guarantee their viability. The paper proposes an innovative methodological basis for evaluating the level of appropriateness of the healthcare service and, at the same time, evidences the need for achieving a balanced triple target of efficiency, effectiveness and sustainability (EES) in healthcare service systems governance. As a result, a new area of cross fertilization for collaborative research emerges

Odontogenic keratocyst and uterus bicornis in nevoid basal cell carcinoma syndrome: Case report and literature review

Nevoid basal cell carcinoma syndrome (NBCCS), an autosomal dominant disorder with a high degree of penetrance and variable expressivity, is characterized by basal cell carcinomas, odontogenic keratocysts, palmar and/or plantar pits and ectopic calcifications of the falx cerebri. More than 100 minor criteria have been described but two major and one minor criteria or one major and three minor criteria are necessary for the diagnosis. In this report we present a 8 year old girl affected by NBCCS showing an uterus bicornis, an hitherto unreported association. However further researches are needed to confirm the association between NBCCS and mullerian fusion defects and to assess the hypothesis that focuses on chromosome 9 the mutant gene for NBCCS and fusion defects of female genital tract

Fiber Bragg Grating sensors for deformation monitoring of GEM foils in HEP detectors

Fiber Bragg Grating (FBG) sensors have been so far mainly used in high energy physics (HEP) as high precision positioning and re-positioning sensors and as low cost, easy to mount, radiation hard and low space- consuming temperature and humidity devices. FBGs are also commonly used for very precise strain measurements. In this work we present a novel use of FBGs as flatness and mechanical tensioning sensors applied to the wide Gas Electron Multiplier (GEM) foils of the GE1/1 chambers of the Compact Muon Solenoid (CMS) experiment at Large Hadron Collider (LHC) of CERN. A network of FBG sensors has been used to determine the optimal mechanical tension applied and to characterize the mechanical stress applied to the foils. The preliminary results of the test performed on a full size GE1/1 final prototype and possible future developments will be discussed.Comment: Four pages, seven figures. Presented by Michele Caponero at IWASI 2015, Gallipoli (Italy

An integrated reconstruction of the multiannual wave pattern in the gulf of naples (South-Eastern Tyrrhenian Sea, Western Mediterranean Sea)

Surface gravity waves retrieved by a network of HF (High Frequency) radars and measured in situ by an ADCP (Acoustic Doppler Current Profiler) current meter connected to an elastic beacon were used to carry out a multiple-year characterization of the wave field of the Gulf of Naples (south-eastern Tyrrhenian Sea, western Mediterranean). The aim of the work was to create a climatology of the study area and to demonstrate the potential of an integrated platform for coastal studies. The patterns recorded by the different instruments were in agreement with the wave climatology of the southern Tyrrhenian Sea as well as with previous scores for the same area. The results presented in this work also highlight seasonal and interannual consistency in the wave patterns for each site. In a wider context, this study demonstrates the potential of HF radars as long-term monitoring tools of the wave field in coastal basins, and supports the development of integrated observatories to address large-scale scientific challenges such as coastal ocean dynamics and the impact of global change on the local dynamics

Eco-friendly gas mixtures for Resistive Plate Chambers based on Tetrafluoropropene and Helium

Due to the recent restrictions deriving from the application of the Kyoto protocol, the main components of the gas mixtures presently used in the Resistive Plate Chambers systems of the LHC experiments will be most probably phased out of production in the coming years. Identifying possible replacements with the adequate characteristics requires an intense R&D, which was recently started, also in collaborations across the various experiments. Possible candidates have been proposed and are thoroughly investigated. Some tests on one of the most promising candidate - HFO-1234ze, an allotropic form of tetrafluoropropane- have already been reported. Here an innovative approach, based on the use of Helium, to solve the problems related to the too elevate operating voltage of HFO-1234ze based gas mixtures, is discussed and the relative first results are shown.Comment: 9 pages, 6 figures, 1 tabl

Evaluation of HF-radar wave measures in the Gulf of Naples

HF-radar systems are commonly employed for detecting the upper sea currents. Nevertheless, the signal of such systems can be further post-processed for characterizing as well the wave characteristics, though this is a recent application whose reliability has not been yet exhaustively investigated. In this work, we evaluate HF-radar measures of significant wave height, wave mean period and incident direction against the outcomes of two numerical models previously validated. The comparison is developed in the Gulf of Naples (hereinafter GoN), taking advantage of three antennas placed in the locations of Castellamare di Stabia, Portici and Sorrento. First, a wave hindcast defined on a regional scale is employed; then, wave data are down-scaled through a local model defined over a finer resolution (local scale). The agreement between the systems is evaluated through statistical error indexes. Results show good consistency, leaving room for deepening the use of radars for wave data collection

Properties of potential eco-friendly gas replacements for particle detectors in high-energy physics

Gas detectors for elementary particles require F-based gases for optimal performance. Recent regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. This work studies properties of potential eco-friendly gas replacements by computing the physical and chemical parameters relevant for use as detector media, and suggests candidates to be considered for experimental investigation

HF Radar Measurements of Surface Waves in the Gulf of Naples (Southeastern Tyrrhenian Sea): Comparison With Hindcast Results at Different Scales

HF radar systems wave measurements are evaluated against numerical simulations in the Gulf of Naples (Southeastern Tyrrhenian Sea). Wave measurements are obtained from three CODAR SeaSonde HF radars installed along the coast of the Gulf of Naples. The numerical models employed are WavewatchIII, implemented on a regional scale with a resolution of about 10 km in longitude and latitude in the whole Mediterranean Sea, and SWAN, implemented with a 200 m resolution in the area of interest. Numerical simulations are also validated against experimental data acquired by a buoy installed offshore the Gulf of Naples. The agreement between HF radar measurements and model hindcasts is evaluated through the estimate of statistical error indices for the main wave characteristics (significant wave height, mean period, and mean direction). The consistency between wave parameters retrieved by HF radars and hindcasted by the models opens the way to future integration of the two systems as well as to the utilization of HF radar wave parameters that could be envisaged for data assimilation in wave models

Properties of potential eco-friendly gas replacements for particle detectors in high-energy physics

Modern gas detectors for detection of particles require F-based gases for optimal performance. Recent regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. This review studies properties of potential eco-friendly gas candidate replacements.Comment: 38 pages, 9 figures, 8 tables. To be submitted to Journal of Instrumentatio