1,093 research outputs found
Evaluation of the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of Sida cordifolia L. (Malvaceae)
The cardiovascular effects of vasicine, an alkaloid isolated from the leaves of Sida cordifolia L., were evaluated in this work. In non-anaesthetized rats (n=6), vasicine (1, 2.5, 5 and 10 mg/kg; i.v., randomly) induced hypotension associated with an intense bradycardia. Both responses were completely abolished after atropine (2mg/Kg; i.v.) and attenuated after hexamethonium (20 mg/Kg; i.v.). In isolated rat mesenteric artery rings, vasicine (0.03, 0.1, 0.3, 1, 3, 10, 30, 100 and 300 μg/mL, cumulatively) induced concentration-dependent relaxation of phenylephrine-induced tone (IC50= 3.8±0.9 μg/mL; n = 6). In conclusion, the results show that vasicine produce hypotension and bradycardia which appears to be due to the stimulation of cardiac muscarinic receptors (directly and/or indirectly), and by a decrease of the peripheral resistances
Body composition and nutritional requirements of protein and energy for body weight gain of lambs browsing in a tropical semiarid region
Sistemas produtivos de caprinocultura leiteira no semiárido paraibano: caracterização, principais limitantes e avaliação de estratégias de intervenção
Neodusmetia sangwani (Subba Rao) (Hymenoptera: Encyrtidae) to control Antonina graminis (Maskell) (Hemiptera: Pseudococcidae) in pastures in Brazil: a revision
Similaridade florística entre estratos da vegetação em quatro Florestas Estacionais Deciduais na bacia do Rio São Francisco
Water relations of field-grown grapevines in the São Francisco Valley, Brazil, under different rootstocks and irrigation strategies
The nitrogen sufficiency index underlying estimates of nitrogen fertilization requirements of common bean
Potencialidades da metacaolinita e do tijolo queimado moído como substitutos parciais do cimento Portland
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