Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers

With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials. This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes

Bibliometric analysis of the top-cited articles on idiopathic intracranial hypertension

Objective: To identify and characterize the top-cited articles on idiopathic intracranial hypertension

Late onset aura may herald cerebral amyloid angiopathy: A case report

Background Although migraine usually begins in the early decades of life, late onset of migraine with aura is occasionally observed and can occur without headache, causing confusion in the differential diagnosis

The Contribution of Neuroimaging to Diagnosis in Idiopathic Intracranial Hypertension

Objective: Due to difficulties in diagnosis, the presence of patients with idiopathic intracranial hypertension (IIH) without papilledema has led to the addition of neuro-radiologic features, which are indicative of increased intracranial pressure, to new diagnostic criteria. In this study, it was aimed to investigate the inter-rater agreement regarding the evaluation of neuroimaging findings of patients diagnosed as having definite IIH and to detect their possible contribution to diagnosis

Impaired Olfactory Function in Patients with Mesial Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis

Objectives: It has been proposed that olfactory function disorders, such as parosmia or hyposmia, were associated with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). In this study, we aimed to compare the olfactory function and its subtypes between MTLE-HS and healthy controls

Neuron-specific enolase levels as a marker for possible neuronal damage in idiopathic intracranial hypertension

Although formerly considered as a "benign" disease, the presence of some important problems such as vision loss, resistance to appropriate medical treatment and relapses suggests that neuronal damage might play a role in the pathophysiology of IIH. In order to demonstrate possible neuronal damage/dysfunction participating in IIH pathophysiology, we aimed to investigate the relationship between serum neuron-specific enolase (NSE) levels and clinical features in patients with idiopathic intracranial hypertension (IIH). Thirty-six patients with IIH, diagnosed according to the revised criteria, and 40 age, gender and body mass index-matched healthy controls were enrolled in this study after their consent. Serum samples were evaluated for NSE via enzyme-linked immunosorbent assay method. NSE levels were higher in the IIH group (23.7 +/- 14.53 ng/ml) compared to the control group (22.7 +/- 13.11 ng/ml), but the difference was not statistically significant (p = 0.824). There were also no statistically significant differences in NSE levels in IIH patients regarding the presence of visual loss, relapse, oligoclonal bands and papilledema. We could not demonstrate any correlations between NSE levels and age, body mass index, cerebrospinal fluid opening pressure and disease duration. The present study is the first to analyze NSE levels in IIH patients and showed no significant difference between patients and controls, and also between different clinical subgroups of IIH patients