Human serum albumin: twenty-three genetic variants and their population distribution

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66001/1/j.1469-1809.1973.tb00602.x.pd

Genetic studies of the Macushi and Wapishana Indians

Blood samples from 509 Macushi (3 villages) and 623 Wapishana (11 villages) of Northern Brasil and Southern Guyana have been analyzed with respect to the phenotype and gene frequencies at the following 12 polymorphic loci: AB0, Kell-Cellano, MNSs, Rh, P, Duffy, Kidd, Diego, Lewis, Group-specific component, and the immunoglobulin allotypes of the Gm and Inv systems. The data suggest that 5–6% of the Wapishana gene pool is derived from non-Indians but only 1–2% of the Macushi. Inter- and intratribal genetic distances between villages are calculated for these data in an effort to understand gene flow between the tribes and to account for the unusual distribution of a newly-discovered genetic polymorphism of erythrocyte esterase A thus far limited to these 2 tribes (Neel et al., 1977). The data are puzzling and consistent with the possibility that both the Craib-speaking Macushi and the Arawak-speaking Wapishana have derived the esterase A allele in question from some third group now extinct or thus far undiscovered. Intertribal genetic distances based on gene frequencies at 6 loci are derived for 20 Amerindian tribes (including these 2); the “central” position of these 2 tribes can in part be explained by the active migration matrix connecting them.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47606/1/439_2004_Article_BF00393584.pd

Electrophoretic variants in three Amerindian tribes: The Baniwa, Kanamari, and Central Pano of Western Brazil

Data are presented on electrophoretic variants of 25 polypeptides found in the blood serum and erythrocytes, in 812 individuals from three Amerindian tribes, the Pano, the Baniwa, and the Kanamari. Two “private polymorphisms” were encountered, of PEPB in the Pano and CAII in the Baniwa. A single example of a different PEPB variant was encountered in the Baniwa, and two possible examples of an unstable variant of HGB A 2 in the Kanamari. In addition, the well-known A variant of ACP 1 , the Duarte variant of GALT, the 2 variant of Hp and the 2 variant of PGM 1 occurred in polymorphic proportions in all three tribes, and the TF D Chi variant was present as a polymorphism in the Baniwa. These data have recently been incorporated into a treatment which concludes that the eight electrophoretically-defined “private polymorphisms” thus far encountered in Amerindian tribes can be explained by a mutation pressure of 0.7 × 10 −5 /locus/generation on the assumption of neutrality of the phenotypes in question (Neel and Thompson, '78).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37590/1/1330500212_ftp.pd

Estudos epidemiológicos entre populações indígenas da Amazônia. II. Prevalências da microfilaremia de Mansonella ozzardi: comparação de dois métodos de diagnóstico ()

The prevalence of microfilaremia among a representative sample of the adolescents and adults in 13 Brazilian Amazon Indian villages was determined for July-August, 1976. With Giemsa-stained peripheral blood smears, preparations from peripheral blood lymphocyte cultures, or both, 533 persons aged 10 years and older and 68 children below age 10 were tested. Mansonella ozzardi was the only blood-borne microfilarial species found. Prevalence was highly village-specific. In four of 13 villages persons tested had no detectable microfilaremia by the methods used. In four other villages the overall prevalences for residents aged 10 years and older were in excess of 60% by one of the methods used. In villages where microfilaremia was documented only five (13%) of the total 38 children tested were positive. There was a general trend for prevalence to rise with increasing age. The ratio of the prevalence of microfilaremia among males to that among females was approximately 1.4:1 with peripheral blood smear test results but exactly 1:1 with the other method. In each of the five microfilaremia-positive villages tested using both methods, we detected a higher prevalence of microfilaremia with the preparations made from the lymphocyte culture studies.Foi determinada a prevalência de microfilaremia em uma amostra representativa de adolescentes e adultos, em 13 aldeias, de índios amazônicos brasileiros em julho-agosto de 1976. Através de esfregaço de sangue periférico corados com Giemsa e de preparações de culturas de linfócitos de sangue periférico, ou ambas, foram testadas 533 pessoas com idade acima de 10 anos e 68 crianças com menos de 10 anos. A Mansonella ozzardi foi a única espécie de microfilária encontrada. A prevalência foi altamente aldeia-específica. Em quatro (4) das 13 aldeias, houve casos de não detecção de microfilaremia pelos métodos usados. Em quatro (4) outras aldeias, as prevalências encontradas para os residentes de 10 anos e mais velhos foram em excesso de 60% para cada método utilizado. Em aldeias onde a microfilaremia foi documentada, apenas cinco (13%) do total de 38 crianças testadas foram positivas. Houve uma tendência geral da prevalência aumentar com o aumento da idade, A razão de prevalência de microfilaremia entre homens e mulheres foi de aproximadamente 1,4:1 para o teste de esfregaço de sangue periférico e exatamente 1:1 para o outro. Em cada 5 aldeões com microfilaremia-positiva testados com ambos os métodos, detectamos uma mais alta prevalência da microfilaremia com as preparações feitas de cultura de linfócitos

Genetic studies of the Macushi and Wapishana Indians

Blood samples from 509 Macushi and 623 Wapishana Amerindians of Northern Brazil and Southern Guyana have been analyzed with reference to the occurrence of rare variants and genetic polymorphisms of the following 25 systems: (i) Erythrocyte enzymes : acid phosphatase-1, adenosine deaminase, adenylate kinase-k, carbonic anhydrase-1, carbonic anhydrase-2, esterase A 1,2,3, esterase D, galactose-1-phosphate uridyltransferase, isocitrate dehydrogenase, lactate dehydrogenase, malate dehydrogenase, nucleoside phosphorylase, peptidase A, peptidase B, phosphoglucomutase 1, phosphoglucomutase 2, phosphogluconate dehydrogenase, phosphohexoseisomerase, triosephosphate isomerase and (ii) Serum proteins : albumin, ceruloplasmin, haptoglobin, hemoglobin A, hemoglobin A 2 and transferrin. Fifteen different rare variants were detected, involving 11 of these systems. In addition, a previously undescribed variant of ESA 1,2,3 which achieves polymorphic proportions in both these tribes is described. Excluding this variant, the frequency of rare variants is 1.1/1000 in 12510 determinations in the Macushi and 4.7/1000 in 15 396 determinations in the Wapishana. The ESA 1,2,3 , polymorphism was not observed in 382 Makiritare, 232 Yanomama, 146 Piaroa, 404 Cayapo, 190 Kraho and 112 Moro. Irregularities in the intratribal distribution of this polymorphism in the Macushi and Wapishana render a decision as to the tribe of origin impossible at present. Gene frequencies are also given for previosly described polymorphisms of 5 systems: haptoglobin, phosphoglucomutase 1, erythrocyte acid phosphatase, esterase D, and galactose-1-phosphate-uridyl-transferase.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47605/1/439_2004_Article_BF00390440.pd