25,376 research outputs found
Atomistic subsemirings of the lattice of subspaces of an algebra
Let A be an associative algebra with identity over a field k. An atomistic
subsemiring R of the lattice of subspaces of A, endowed with the natural
product, is a subsemiring which is a closed atomistic sublattice. When R has no
zero divisors, the set of atoms of R is endowed with a multivalued product. We
introduce an equivalence relation on the set of atoms such that the quotient
set with the induced product is a monoid, called the condensation monoid. Under
suitable hypotheses on R, we show that this monoid is a group and the class of
k1_A is the set of atoms of a subalgebra of A called the focal subalgebra. This
construction can be iterated to obtain higher condensation groups and focal
subalgebras. We apply these results to G-algebras for G a group; in particular,
we use them to define new invariants for finite-dimensional irreducible
projective representations.Comment: 14 page
Anti-Tumor Effects of TRAIL-Expressing Mesenchymal Stromal Cells in a Mouse Xenograft Model of Human Mesothelioma
Malignant mesothelioma (MM) remains a highly deadly malignancy with poor treatment option. The MM cells further promote a highly inflammatory microenvironment which contributes to tumor initiation, development, severity, and propagation. We reasoned that the anti-inflammatory actions of mesenchymal stromal cells (MSCs) and further anti-tumor effects of MSCs engineered to over-express TNF-related apoptosis inducing ligand (TRAIL) protein (MSC-TRAIL) would effectively inhibit mesothelioma growth. Using a mouse xenograft model of intraperitoneal human mesothelioma, native mouse (mMSC) or human (hMSC) MSCs were administered either systemically (IV) or intraperitoneally (IP) at various times following tumor inoculation. Both mMSCs and hMSCs localized at sites of MM tumor growth in vivo and decreased local inflammation. Further, a trend towards decrease in tumor burden was observed. Parallel studies of in vitro exposure of nine primary human mesothelioma cell lines to mMSCs or hMSCs demonstrated reduced tumor cell migration. In contrast MSC-TRAIL exposure induced apoptosis of TRAIL sensitive MM cells in vitro and both mouse and human MSC-TRAIL significantly reduced the inflammatory tumor environment in vivo. Moreover human MSC-TRAIL administration significantly reduced peritoneal tumor burden in vivo and increased tumor cell apoptosis. These proof-of-concept studies suggest that TRAIL-expressing MSCs may be useful against malignant mesothelioma
Insensitivity of Ion Motional Heating Rate to Trap Material over a Large Temperature Range
We present measurements of trapped-ion motional-state heating rates in
niobium and gold surface-electrode ion traps over a range of trap-electrode
temperatures from approximately 4 K to room temperature (295 K) in a single
apparatus. Using the sideband-ratio technique after resolved-sideband cooling
of single ions to the motional ground state, we find low-temperature heating
rates more than two orders of magnitude below the room-temperature values and
approximately equal to the lowest measured heating rates in similarly-sized
cryogenic traps. We find similar behavior in the two very different electrode
materials, suggesting that the anomalous heating process is dominated by
non-material-specific surface contaminants. Through precise control of the
temperature of cryopumping surfaces, we also identify conditions under which
elastic collisions with the background gas can lead to an apparent steady
heating rate, despite rare collisions.Comment: v1: 6 pages, 3 figures; v2: 7 pages, 3 figures, analysis of
temperature dependence and calculation of effects of collisions expanded and
improved, minor errors corrected in discussions of Johnson noise and
collisions and in appendix
Why some politicians are more dangerous than others
Politicians and the political process, even in ostensibly democratic countries, can be deadly. James Gilligan’s book details how over the past century, whenever America’s conservative party have gained the presidency, the country has repeatedly suffered from epidemics of suicide and homicide. Daniel Sage finds the book an enlightening study, and also an important example of the increasingly powerful relationship between epidemiology and social science. Why Some Politicians Are More Dangerous Than Others. James Gilligan. Polity Books. September 2011
Corporate Social Responsibility at Gap: An Interview with Eva Sage-Gavin
Gap Inc. is one of the world\u27s largest specialty retailers, with more than 3,000 stores and fiscal 2005 revenues of $16 billion. They operate four of the most recognized apparel brands in the world — Gap, Banana Republic, Old Navy and Forth & Towne. According to the company website “At Gap Inc., social responsibility isn\u27t just a catchphrase or a feel good initiative. It\u27s a reflection of who we are and how we operate as a company. To us, being socially responsible means striving to embed our values and ethics into everything we do — from how we run our business, to how we treat our employees, to how we impact the communities where we do business. In 2003 Gap Inc. was the first retailer to release a social responsibility report, offering a comprehensive overview of their approach to social responsibility. The report was broadly lauded for its willingness to be open and honest about both the successes and failures in this arena. In fact, this report won Business Ethics magazine\u27s Social Reporting Award for unprecedented honesty in reporting on factory conditions. Their 2004 Social Responsibility Report continued that discussion and provided new information on their progress, challenges, and new initiatives. Eva Sage-Gavin is Executive Vice President, Human Resources and Corporate Communications, of Gap Inc. In her role as Chief People Officer, she sets the strategy for the company\u27s communications and human resources operations worldwide, including staffing, diversity, rewards, recognition, employee benefits, learning and development, strategic change, and internal and external communications. She set aside time to provide more specifics to how and why Gap Inc. places so much emphasis on corporate social responsibility
Bio-Processes of the Oxidation Ditch When Subjected to a Sub-Arctic Climate
Alaska's far northern area is sparsely populated primarily because of a
severe climate which varies from northern temperate to Arctic. Construction
and power costs are high. Skilled operating personnel are scarce and
expensive, if available. Receiving streams are said to be delicate, particularily
in the winter, when little possibility for reaeration exists due to a total ice cover. The oxidation ditch modification of the extended aeration activated sludge process appears to be well suited for the
treatment of wastes in this environment. Past operating data on a plant
of this type located in Interior Alaska (near Fairbanks) indicated it may
be well suited to treat small volumes of domestic waste economically,
with low sludge production, and minimal sensitivity to low temperatures.The work reported on herein was done under Contract No. RFP DACA 897l-
R-0006 from the U. S. Army Cold Regions Research and Engineering
Laboratory, Hanover, New Hampshire
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