Impact of comorbid conditions on asthmatic adults and children

Comorbid conditions (comorbidities) can complicate the diagnosis and management of asthma. In different age groups, comorbid conditions can present varying challenges, including diagnostic confusion due to mimicking asthma symptoms, exacerbation of asthma symptoms, therapy for comorbid conditions affecting asthma or therapy for asthma affecting these conditions. This review aims to summarise some common comorbid conditions with asthma, such as rhinitis, vocal cord dysfunction, gastro-oesophageal reflux, psychiatric disorders, obesity and obstructive sleep apnoea, and discuss their prevalence, symptoms, diagnosis and treatment, highlighting any differences in how they impact children and adults. Overall, there is a lack of data on the impact of treating comorbid conditions on asthma outcomes and further studies are needed to guide age-appropriate asthma management in the presence of these conditions.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.A.K. reports personal fees from AstraZeneca, Behring, Boehringer Ingelheim, GlaxoSmithKline, Griffols, Teva, Novartis, Novo Nordisk, Paladdin, Pfizer, Purdue, Sanofi and Trudel, outside the submitted work. D.M.G.H. reports personal fees from AstraZeneca, Chiesi and Pfizer and grants and personal fees from Boehringer Ingelheim, GlaxoSmithKline and Novartis, outside the submitted work. S.J.S. reports fees from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, Propeller Health, Regeneron and Sanofi, outside the submitted work all paid to the University of Colorado School of Medicinepublished version, accepted version, submitted versio

Spin-motive force due to a gyrating magnetic vortex

A change of magnetic flux through a circuit induces an electromotive force. By analogy, a recently predicted force that results from the motion of non-uniform spin structures has been termed the spin-motive force. Although recent experiments seem to confirm its presence, a direct signature of the spin-motive force has remained elusive. Here we report the observation of a real-time spin-motive force produced by the gyration of a magnetic vortex core. We find a good agreement between the experimental results, theory and micromagnetic simulations, which taken as a whole provide strong evidence in favour of a spin-motive force

Scintillation yield from electronic and nuclear recoils in superfluid He 4

Superfluid He4 is a promising target material for direct detection of light (<1 GeV) dark matter. Possible signal channels available for readout in this medium include prompt photons, triplet excimers, and roton and phonon quasiparticles. The relative yield of these signals has implications for the sensitivity and discrimination power of a superfluid He4 dark matter detector. Using a 16 cm3 volume of 1.75 K superfluid He4 read out by six immersed photomultiplier tubes, we measured the scintillation from electronic recoils ranging between 36.3 and 185 keVee, yielding a mean signal size of 1.25-0.03+0.03 phe/keVee, and nuclear recoils from 53.2 to 1090 keVnr. We compare the results of our relative scintillation yield measurements to an existing semiempirical model based on helium-helium and electron-helium interaction cross sections. We also study the behavior of delayed scintillation components as a function of recoil type and energy, a further avenue for signal discrimination in superfluid He4