2 research outputs found
Selective use of percutaneous testis biopsy to optimize IVF-ICSI outcomes: a case series
Chromosomal damage as prognosis marker in cervical carcinogenesis
Cancer of the uterine cervix is the third most common cancer in women worldwide and the most common cancer among Mexican and Latin American women. Risk factors that have been associated with the development of cervical intraepithelial neoplasia suggest that Human Papillomavirus (HPV) types 16, 18, 31, and 33 entail a high risk of developing a malignancy of this type. The accumulation of genetic alterations allows the growth of neoplastic cells; chromosomal instability is an event that occurs in the precancerous stages. The candidate cancer risk biomarkers include cytogenetic endpoints, such as chromosomal aberrations, sister chromatid exchange, micronuclei, and the outcomes of comet assay and DNA breakage detection-fluorescence in situ hybridization. The patterns identified in these cytogenetic studies indicate that chromosomal instability is a transient and chromosomally unstable intermediate in the development of cervical lesions. In this context, the mechanisms that may underlie the progressive increase in genetic instability in these patients seem to be related directly to HPV infection. The studies discussed in this paper show that chromosomal instability may serve as a biomarker by predicting the progression of cervical intraepithelial neoplasia. Nevertheless, these results should be validated in larger, prospective studies.Π Π°ΠΊ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ΅ΡΡΠΈΠΌ ΠΏΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ Π² ΠΌΠΈΡΠ΅ ΡΠΈΠΏΠΎΠ² ΡΠ°ΠΊΠ° Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ Π²ΡΡΡΠ΅ΡΠ°ΡΡΠΈΠΌΡΡ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ ΠΠ΅ΠΊΡΠΈΠΊΠΈ ΠΈ ΠΠ°ΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΠΌΠ΅ΡΠΈΠΊΠΈ. Π€Π°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ°, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈΠ½ΡΡΠ°ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΠΈ, ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°ΡΡ, ΡΡΠΎ ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΠ°Π²ΠΈΡΡΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (HPV) ΡΠΈΠΏΠΎΠ² 16, 18, 31 ΠΈ 33 Π²Π»Π΅ΡΠ΅Ρ Π·Π° ΡΠΎΠ±ΠΎΠΉ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. ΠΠ°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π΄Π΅Π»Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠΌ ΡΠΎΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½Π°Ρ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΠ±ΡΡΠΈΠ΅ΠΌ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΡΠΌ ΡΡΠ°Π΄ΠΈΡΠΌ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΡ ΡΠΈΡΠΊΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ°ΡΡ ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΠ΅ Π°Π±Π΅ΡΡΠ°ΡΠΈΠΈ, ΠΎΠ±ΠΌΠ΅Π½ ΡΠ΅ΡΡΡΠΈΠ½ΡΠΊΠΈΡ
Ρ
ΡΠΎΠΌΠ°ΡΠΈΠ΄, ΠΌΠΈΠΊΡΠΎΡΠ΄ΡΠ°, ΠΈ Π·Π°ΠΊΠ°Π½ΡΠΈΠ²Π°ΡΡΡΡ Comet-Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ ΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ ΠΏΠΎΠ»ΠΎΠΌΠΎΠΊ ΠΠΠ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ in situ. ΠΠ±ΡΠ°Π·ΡΡ, ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π² ΡΠ°ΠΊΠΈΡ
ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
, ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ, ΡΡΠΎ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½Π°Ρ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ°Π½Π·ΠΈΠ΅Π½ΡΠ½ΡΠΌ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΠΌ Π·Π²Π΅Π½ΠΎΠΌ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ. Π ΡΡΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π»Π΅ΠΆΠ°ΡΡ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠ΅ΠΉ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ Ρ ΡΠ°ΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠ°ΠΆΡΡΡΡ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ²ΡΠ·Π°Π½Π½ΡΠΌΠΈ Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ HPV. ΠΠ°ΡΡΠΎΡΡΠ΅Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ, ΡΡΠΎ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½Π°Ρ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠΌ Π΄Π»Ρ ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°Π½ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ²ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΠΈ, ΡΠ΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΡΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ ΠΎΡΠ΅Π½Π΅Π½Ρ Π² Π±ΠΎΠ»Π΅Π΅ ΠΌΠ°ΡΡΡΠ°Π±Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ