27 research outputs found
OCT Angiography (OCTA) in Retinal Diagnostics
Optical coherence tomography angiography (OCTA) is an imaging modality which can be applied in ophthalmology to provide detailed visualization of the perfusion of vascular networks in the eye. Compared to previous state of the art dye-based imaging, such as fluorescein angiography, OCTA is non-invasive, time-efficient, and it allows for the examination of retinal vasculature in 3D. These advantages of the technique combined with the good usability in commercial devices led to a quick adoption of the new modality in the clinical routine. However, the interpretation of OCTA data is not without problems: Commonly observed image artifacts and the quite involved algorithmic details of OCTA signal construction can make the clinical assessment of OCTA exams challenging. In this article we describe the technical background of OCTA and discuss the data acquisition process, common image visualization techniques, as well as limitations and sources of artifacts of the modality. Examples of clinical cases underline the increasing importance of the OCTA technology in ophthalmology and its relation to dye-based angiography
Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography
The Importance of Signal Strength in Quantitative Assessment of Retinal Vessel Density Using Optical Coherence Tomography Angiography
Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions
Deep Capillary Macular Perfusion Indices Obtained with OCT Angiography Correlate with Degree of Nonproliferative Diabetic Retinopathy
Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography
Optical Coherence Tomography Angiography in Retinal Vein Occlusion Treated with Dexamethasone Implant: A New Test for Follow-Up Evaluation
Relationship between vascular densities of choriocapillaris and the whole choroid using OCTA
Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors
Over recent years, multifunctional compounds that combine diagnostic and therapeutic modalities using one unified material
have been developed and designated as theranostics. These compounds provide the chance to develop individually designed
therapies against various diseases to accomplish personalized medicine. In this review, theranostic agents based on nanovectors
(liposomes, naposomes, micelles, polymeric micelles and micelles built around a solid core) externally modified with targeting
peptides able to simultaneously carry a drug and a contrast agent are described, demonstrating that peptide-modified nanovectors can selectively carry a drug to target cells with an imaging probe co-incorporated into the nanovector to monitor therapy