24 research outputs found
ПРОТЕОМИКА КАК ФУНДАМЕНТАЛЬНЫЙ ИНСТРУМЕНТ ДОКЛИНИЧЕСКОГО СКРИНИНГА, ВЕРИФИКАЦИИ АНАЛИЗОВ И ОЦЕНКИ ПРИМЕНЯЕМОЙ ТЕРАПИИ
Proteomics is a science which studies proteins of the body, interactions of proteins and their biological functions. Today, it is an essential partner in establishing preclinical diagnosis protocols. In conjunction with other sciences such as genomics and bioinformatics it will be possible to diagnose diseases on the earliest stages before its clinical onset or to gain the dynamics of pathological processes in the body and response to drug therapy. This article discusses general aspects of proteomics as well as special ones on the basis of models of cardiac diseases and cancer. Протеомика ― наука, изучающая белки живых организмов, их функции и взаимодействие, на сегодняшний день является незаменимым компонентом в создании протоколов доклинической диагностики. В сочетании с достижениями геномики, биоинформатики, использование технологий протеомики ― мощный инструмент ранней диагностики заболеваний, а также динамической оценки протекания патологических процессов (в частности, на фоне проводимой фармакотерапии). В статье рассмотрены общие и частные аспекты протеомики, основанные на базе моделей кардио- и онкозаболеваний
Extreme values of elastic strain and energy in sine-Gordon multi-kink collisions
In our recent study the maximal values of kinetic and potential energy
densities that can be achieved in the collisions of slow kinks in the
sine-Gordon model were calculated analytically (for , and 3) and
numerically (for ). However, for many physical applications it is
important to know not only the total potential energy density but also its two
components (the on-site potential energy density and the elastic strain energy
density) as well as the extreme values of the elastic strain, tensile
(positive) and compressive (negative). In the present study we give (i) the two
components of the potential energy density and (ii) the extreme values of
elastic strain. Our results suggest that in multi-soliton collisions the main
contribution to the potential energy density comes from the elastic strain, but
not from the on-site potential. It is also found that tensile strain is usually
larger than compressive strain in the core of multi-soliton collision.Comment: 9 pages, 6 figures. arXiv admin note: text overlap with
arXiv:1605.0976
Nonlinear parity-time symmetric closed-form optical quadrimer waveguides: attractor perspective
We report a study on a closed-form nonlinear parity-time symmetric optical
quadrimer waveguides system with a specific coupling scheme. The system yields
power saturation behavior in the modes, which may be attributed to the inherent
attractor in the system. A detailed analysis has been provided to confirm the
attractor aspect of the system. This work also addresses a crucial issue
regarding choice of initial conditions while carrying out numerical simulation
for such systems
Floquet higher-order exceptional points and dynamics in PT-symmetric quadrimer waveguides
The ATLAS Transition Radiation Tracker (TRT) proportional drift tube: design and performance
A straw proportional counter is the basic element of the ATLAS Transition Radiation Tracker (TRT). Its detailed properties as well as the main properties of a few TRT operating gas mixtures are described. Particular attention is paid to straw tube performance in high radiation conditions and to its operational stability
The ATLAS TRT barrel detector
The ATLAS TRT barrel is a tracking drift chamber using 52,544 individual tubular drift tubes. It is one part of the ATLAS Inner Detector, which consists of three sub-systems: the pixel detector spanning the radius range 4 to 20 cm, the semiconductor tracker (SCT) from 30 to 52 cm, and the transition radiation tracker (TRT) from 56 to 108 cm. The TRT barrel covers the central pseudo-rapidity region |h| < 1, while the TRT endcaps cover the forward and backward eta regions. These TRT systems provide a combination of continuous tracking with many measurements in individual drift tubes (or straws) and of electron identification based on transition radiation from fibers or foils interleaved between the straws themselves. This paper describes the recentlycompleted construction of the TRT Barrel detector, including the quality control procedures used in the fabrication of the detecto