41 research outputs found
Investigation of Electro-physical and Physical-mechanical Properties of HTS 2G Tapes
AbstractHigh temperature superconducting tapes of 2nd generation (HTS 2G) are being manufactured by several companies worldwide, which use different methods of fabrication of superconducting layers that affect the behaviour of HTS 2G tapes in actual practice. This paper presents the results of the study of HTS 2G tapes delamination process, the influence of alternating temperature impacts on critical current and the behaviour of current carrying capacity of HTS 2G tapes in external magnetic fields. The abovementioned problems can arise in almost any case of designing devices based on HTS 2G tapes. Furthermore, the developed measuring techniques are very important for controlling of output parameters of HTS 2G tapes that are to be manufactured in NRC āKurchatov instituteā
P.877 A novel dimeric dipeptide mimetics of the BDNF loop 1, 2 and 4 activate the phospholipase cĪ³ signaling pathway
Microwave Radiometry in the Diagnosis of Various Urological Diseases
Microwave radiometry is based on measurement of the intrinsic electromagnetic irradiation of a patientās internal tissues in the ultra-high frequency range. It is used with success in clinical practice. Results of studies of the diagnostic potential of microwave radiometry in different forms of acute pyelonephritis, renal colic, and acute inflammatory diseases of the prostate have demonstrated its informativeness and safety and have determined the value of this method in complex (including early) diagnosis and for monitoring of treatment efficacy. Use of microwave radiometry has been shown to reduce the number of errors and to increase the informativeness of existing X-ray and ultrasound diagnostic methods at the early stages of acute inflammatory diseases of the kidneys and prostate. Ā© 2019, Springer Science+Business Media, LLC, part of Springer Nature
Prospects of non-drug approaches to Alzheimer's disease
Despite the urgency of the problem of prevention and treatment of neurodegenerative processes underlying Alzheimer's disease (AD) and other severe disorders of the central nervous system, therapeutic and prophylactic potential of drugs is yet insufficient. Numerous adverse effects of the drugs, which might improve cognitive function in patients with AD substantiate serious consideration of measures enhancing adaptive potential and mobilizing self-defense of the body. It is clear now that endogenous defense systems of the brain can limit progression of AD long after the onset of the disease. The measures mobilizing the self-defense include administration of natural adaptogens and various types of adaptation, such as adaptation to dietary restrictions, promotion of physical and mental activity, and adaptation to hypoxia. This review presents data supporting a hypothesis that non-drug activation of self-defense of the body can prevent cognitive decline induced by neurodegenerative processes in the brain by targeting key points of AD pathogenesis
Possible use of adaptation to hypoxia in Alzheimer's disease: A hypothesis
Disorders in memory and other cognitive functions in Alzheimer's disease (AD) may result from an exhaustion of adaptive reserves in the brain. Therefore it is a challenge to find methods to increase the adaptive reserve of the organism to combat AD. Excitotoxicity, Ca2+ homeostasis disruptions, oxidative stress, disturbed synthesis of NO, and impaired cerebral circulation are suggested as key pathogenic factors of AD. At present it appears that stimulation of the self-defense systems in neural cells is a promising strategy in restricting the progression of AD. These systems include those of antioxidants, heat shock proteins (HSPs), NO, and other so-called stress-limiting systems. Non-drug activation of these systems can be achieved most efficiently by adaptation of the organism to environmental challenges, such as hypoxia. In this paper the potential of methods used in adaptive medicine is explored. The protective mechanisms of adaptation to hypoxia may be related to restriction of oxidative stress in the hippocampus, the limitation of a decrease in NO production induced by Ī²-amyloid, and increased density of the vascular network in the brain. In this review we selectively present data that support the idea that adaptation to hypoxia is a possible non-drug means in the prevention of AD. In our opinion this strategy may provide a break-through in the clinical approach of this disease. Ā© Med Sci Monit, 2005
Prospects of non-drug approaches to Alzheimer's disease
Despite the urgency of the problem of prevention and treatment of neurodegenerative processes underlying Alzheimer's disease (AD) and other severe disorders of the central nervous system, therapeutic and prophylactic potential of drugs is yet insufficient. Numerous adverse effects of the drugs, which might improve cognitive function in patients with AD substantiate serious consideration of measures enhancing adaptive potential and mobilizing self-defense of the body. It is clear now that endogenous defense systems of the brain can limit progression of AD long after the onset of the disease. The measures mobilizing the self-defense include administration of natural adaptogens and various types of adaptation, such as adaptation to dietary restrictions, promotion of physical and mental activity, and adaptation to hypoxia. This review presents data supporting a hypothesis that non-drug activation of self-defense of the body can prevent cognitive decline induced by neurodegenerative processes in the brain by targeting key points of AD pathogenesis
Possible use of adaptation to hypoxia in Alzheimer's disease: A hypothesis
Disorders in memory and other cognitive functions in Alzheimer's disease (AD) may result from an exhaustion of adaptive reserves in the brain. Therefore it is a challenge to find methods to increase the adaptive reserve of the organism to combat AD. Excitotoxicity, Ca2+ homeostasis disruptions, oxidative stress, disturbed synthesis of NO, and impaired cerebral circulation are suggested as key pathogenic factors of AD. At present it appears that stimulation of the self-defense systems in neural cells is a promising strategy in restricting the progression of AD. These systems include those of antioxidants, heat shock proteins (HSPs), NO, and other so-called stress-limiting systems. Non-drug activation of these systems can be achieved most efficiently by adaptation of the organism to environmental challenges, such as hypoxia. In this paper the potential of methods used in adaptive medicine is explored. The protective mechanisms of adaptation to hypoxia may be related to restriction of oxidative stress in the hippocampus, the limitation of a decrease in NO production induced by Ī²-amyloid, and increased density of the vascular network in the brain. In this review we selectively present data that support the idea that adaptation to hypoxia is a possible non-drug means in the prevention of AD. In our opinion this strategy may provide a break-through in the clinical approach of this disease. Ā© Med Sci Monit, 2005