Merrifield resin-linked polyazole-based sorbent for heavy metal ions extraction from water

A new sorbent for heavy metal ions, that contains links with fragments of 1,2,3-triazole, 1,2,3- and 1,2,4-triazole, both triazoles and tetrazole was developed and appropriate procedures for the synthesis of these links were described. The obtained polymer is able to form stable complexes with the ions of heavy metals, such as Eu(III), Cd(II), Pb(II), Cu(II), Sr(II). The extraction rate dependence on the age of the sorbent, concentration of the cations, pH, and concentration of competing anions was studied

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner-Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity. © 2019 Murlykina et al