5 research outputs found
SĂndrome de SĂ©zary em cadela SĂ©zary syndrome in a bitch
The present report describes a case of Sezary syndrome in a canine with lymphadenomegaly, generalized erithroderma, intense pruritus and disseminated cutaneous nodules and plaques. Biopsy samples were taken from cutaneous nodules and plaques and were diagnosed epitheliotropic T cell cutaneous lymphoma by histology and immunohistochemical stain. Bone marrow cytology confirms leukemia. Diagnosis of Sezary syndrome was achieved through clinical, hematological, citopathological, histopathological and immunohistochemical findings. The patient was treated with Madison-Wisconsin chemotherapy protocol, but died after two mouths of treatment
Proteinograma sérico de cães sadios e com linfoma obtido por eletroforese em gel de poliacrilamida (SDS-PAGE) Serum protein concentrations in healthy dogs and dogs with lymphoma by means of sodium dodecil sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
Foram avaliadas amostras de soro sanguĂneo de 10 cĂŁes sadios e de 12 com linfoma, utilizando-se a eletroforese em gel de poliacrilamida contendo dodecil sulfato de sĂłdio. Houve diferença entre as mĂ©dias dos teores de proteĂna total de cĂŁes sadios, 7,68g/dL±0,46 e de cĂŁes com linfoma, 7,93g/dL±2,49. As concentraçÔes de IgA e IgG nĂŁo foram diferentes entre os grupos. Os teores das proteĂnas de pesos moleculares 142000, 110000, 52000, 49000, 24000 e 18000 dĂĄltons foram mais elevados em cĂŁes com linfoma. Os cĂŁes com linfoma apresentaram concentraçÔes mais elevadas de ceruloplasmina, 43,95mg/dL±18,19, e haptoglobina, 554mg/dL±449,51, e menores de albumina, 2908mg/dL±476,67, em comparação aos cĂŁes sadios (ceruloplasmina: 3,42mg/dL±7,44; haptoglobina: 94,54mg/dL±59,50 e albumina: 4207mg/dL±206,18). Conclui-se que concentraçÔes sĂ©ricas mais elevadas de ceruloplasmina e haptoglobina e menores de albumina podem estar associadas ao linfoma em cĂŁes.Blood serum samples of ten healthy dogs and 12 dogs with lymphoma were evaluated by means of sodium dodecil sulphate-polyacrylamide gel electrophoresis. There was difference in total protein concentrations among healthy dogs, 7.68g/dL±0.46 and dogs with lymphoma, 7.93g/dL±2.49 values of immunoglobulins A and G presented no difference between groups. Serum proteins with molecular weights 142,000; 110,000; 52,000; 49,000; 24,000; and 18,000 Daltons presented increased concentrations in dogs with lymphoma. Dogs with lymphoma presented increased ceruloplasmin (43.95mg/dL±18.19) and haptoglobin (554mg/dL±449.51) values and lesser albumin concentration (2,908mg/dL±476.67) when compared to healthy dogs (ceruloplasmin: 3.42mg/dL±7.44; haptoglobin: 94.54mg/dL±59.50, and albumin: 4,207mg/dL±206.18). In conclusion, increased ceruloplasmin and haptoglobin and lesser albumin serum concentrations are possibly related to lymphoma in dogs