23 research outputs found
gdt1, a New Signal Transduction Component for Negative Regulation of the Growth–Differentiation Transition in Dictyostelium discoideum
Shape Sensitivity of Free-Surface Interfaces Using a Level Set Methodology
In this paper we develop the continuous adjoint methodology to compute shape sensitivities in free-surface hydrodynamic design problems using the incompressible Euler equations and the level set methodology. The identification of the free-surface requires the convection of the level set variable and, in this work, this equation is introduced in the entire shape design methodology. On the other hand, an alternative continuous adjoint formulation based in the jump condition across the interface, and an internal adjoint boundary condition is also presented. It is important to highlight that this new methodology will allow the specific design of the free-surface interface, which has a great potential in problems where the target is to reduce the wave energy (ship design), or increase the size of the wave (surfing wave pools). The complete continuous adjoint derivation, the description of the numerical methods (including a new high order numerical centered scheme), and numerical tests are detailed in this paper. I
Stereochemistry of charged nitrogen-aromatic interactions and its involvement in ligand-receptor binding
Prevalence of the addictions: a problem of the majority or the minority?
An increasing number of research studies over the last three decades suggest that a wide range of substance and process addictions may serve similar functions. The current article considers 11 such potential addictions (tobacco, alcohol, illicit drugs, eating, gambling, Internet, love, sex, exercise, work, and shopping), their prevalence, and co-occurrence, based on a systematic review of the literature. Data from 83 studies (each study n = at least 500 subjects) were presented and supplemented with small-scale data. Depending on which assumptions are made, overall 12-month prevalence of an addiction among U.S. adults varies from 15% to 61%. The authors assert that it is most plausible that 47% of the U.S. adult population suffers from maladaptive signs of an addictive disorder over a 12-month period and that it may be useful to think of addictions as due to problems of lifestyle as well as to person-level factors
NSF/IEEE-TCPP curriculum initiative on parallel and distributed computing - Core topics for undergraduates
This special session will be our first formal curriculum committee report. A working group from IEEE Technical Committee on Parallel Pr