Hyperthermic seizures: an animal model for hot-water epilepsy

Freely ambulant wistar adult rats of both sexes when exposed to a hot water jet on the head (50°C–55°C) for a period of 8–10 minutes, manifested seizure activity similar to the ones noted in ‘hot-water epilepsy’ (HWE) in humans. Depth electrode recording from the hippocampus revealed seizure discharges during the ictus lasting from 34 seconds to three minutes, followed by low voltage indeterminate activity and a quiescent resting phase. Seizure initiation was noted to be critically dependent on the rectal temperature of 41.5°C and regional hippocampal temperature of 37°C. There appeared to be no clear evidence for kindling phenomenon. Intervention of hyperthermia by cooling the body after the ictus prevented subsequent occurrence of spontaneous seizures. Pathological study of the brain revealed ischaemic changes in specific topographic areas like Sommer's sector in hippocampus, layer 4 and 5 neurons of the cerebral cortex and reticular neurons in the brain stem—a pathological feature reminiscent of the human epileptic brain. Seizure initiation by hyperthermic stimulation with hot water poured over the head, the progression and the EEG recording the seizure activity in these rats appears to resemble the HWE in human subjects and could thus serve as the first animal model for this form of ‘reflex’ epilepsy. This has given new insight into the understanding of human HWE. Our preliminary observations in humans has suggested that HWE is a type of hyperthermic seizure similar to febrile convulsion but differs from it with respect to stimulus and rate of rise in temperature in a susceptible individual

Radioiodine Therapy for Hyperthyroidism Changing Pattern of Management over Three Decades at INMAS

Iodine - 131 therapy is a relatively simple, effective and economical method of treating hyperthyroidism. Even fifty years after the introduction of radioactive iodine, there is no concensus on the approach for selection of the dose for treatment of hyperthyroidism. Since the last three decades, the approach for radioiodine therapy at this Institute has been to treat with low, fractionated doses to produce partial destruction of the thyroid gland leaving the patient sufficient functioning gland for normal hormone production. New in vitro diagnostic techniques including free T/sub 3/, T/sub 4/ and sensitive TSH assay have been introduced over the past decade for the diagnosis of hyperthyroidism. Changes in the thyroid radioactive iodine uptake in the population due to introduction of iodized salt, and the high incidence of persistent hyperthyroidism after low dose radioiodine therapy, have prompted to go for a proporptionate increase in the /sup 131/I original dose schedules based on goitre grades. This has led to nominal increase in the incidence of post therapy hypothyroidism. However, the basic principle of low, fractionated dose therapy is still being followed at this Institute, which appears suitable for our social and economic condition

Rough Set-hypergraph-based Feature Selection Approach for Intrusion Detection Systems

Immense growth in network-based services had resulted in the upsurge of internet users, security threats and cyber-attacks. Intrusion detection systems (IDSs) have become an essential component of any network architecture, in order to secure an IT infrastructure from the malicious activities of the intruders. An efficient IDS should be able to detect, identify and track the malicious attempts made by the intruders. With many IDSs available in the literature, the most common challenge due to voluminous network traffic patterns is the curse of dimensionality. This scenario emphasizes the importance of feature selection algorithm, which can identify the relevant features and ignore the rest without any information loss. In this paper, a novel rough set κ-Helly property technique (RSKHT) feature selection algorithm had been proposed to identify the key features for network IDSs. Experiments carried using benchmark KDD cup 1999 dataset were found to be promising, when compared with the existing feature selection algorithms with respect to reduct size, classifier’s performance and time complexity. RSKHT was found to be computationally attractive and flexible for massive datasets

Physical properties of an Indian Ayurvedic medicine (<em>Shankh Bhasma</em>) as nano materials for its application

178-183The aim of present study is to describe Physical properties of an Indian Ayurvedic medicine (Shankh Bhasma) as nano materials for its applications. Shankh Bhasma has been synthesized by using method mentioned in an Ayurvedic text using conch shell and characterized by the modern scientific tools such as; X-ray diffractomter (XRD), Fourier Transform spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Vibrating Sample Magnetometer (VSM).When we treated shankh bhasma on C. elegans and E. coli. C elegans produces more egg than normal calcium and there is no effect on E. coli. X-ray diffraction pattern and SEM analysis revealed that this Bhasma is in agglomerated nano crystalline materials and be considered as nanomedicine. An FTIR measurement reveals the bond stretching during the incineration process and found peaks of carboxylic group, Carbon with chloride and fluroide. Magnetization-Hysteresis (MH) loop study by the Vibrating sample magnetometer reveals that the di-magnetic nature of the Bhasma. Investigation of Shankh bhasma nanoparticles on C. elegen shows slightly increasing in egg production with compare to normal calcium oxide. There is not bacterial static effect was found on E.coli

Model for Glass Transition in a Binary fluid from a Mode Coupling approach

We consider the Mode Coupling Theory (MCT) of Glass transition for a Binary fluid. The Equations of Nonlinear Fluctuating Hydrodynamics are obtained with a proper choice of the slow variables corresponding to the conservation laws. The resulting model equations are solved in the long time limit to locate the dynamic transition. The transition point from our model is considerably higher than predicted in existing MCT models for binary systems. This is in agreement with what is seen in Computer Simulation of binary fluids. fluids.Comment: 9 Pages, 3 Figure

Is the O(3) σO(3)~\sigma Model with the Hopf Term Exactly Equivalent to a Higher Spin Theory?

We write down a local $CP_1$ model involving two gauge fields, which is exactly equivalent to the O(3) $\sigma$ model with the Hopf term. We impose the $CP_1$ constraint by using the gaussian representation of the delta function. For the coefficient of the Hopf term, $\theta = {\pi \over 2s}$, 2s being an integer, we show that the resulting model is exactly equivalent to an interacting theory of spin-$s$ fields. Thus we conjecture that there should be a fixed point in the spin-$s$ theory near which it is exactly equal to the $\sigma$ model.Comment: 11 page

Fluctuation-dissipation relationship in chaotic dynamics

We consider a general N-degree-of-freedom dissipative system which admits of chaotic behaviour. Based on a Fokker-Planck description associated with the dynamics we establish that the drift and the diffusion coefficients can be related through a set of stochastic parameters which characterize the steady state of the dynamical system in a way similar to fluctuation-dissipation relation in non-equilibrium statistical mechanics. The proposed relationship is verified by numerical experiments on a driven double well system.Comment: Revtex, 23 pages, 2 figure