6 research outputs found
DIJAMETAR I MASA OÄNE LEÄE KAO INDIKATOR STAROSTI Leiognathus equulus SAKUPLJENIH IZ MORA OMANA
In the leiognathid fish, Leiognathus equulus the diameter of the eye lens can be used for identifying first-year animals, while the eye lens weight proved unreliable for age determination.Kod vrste, Leiognathus equulus koriÅ”ten je dijametar oÄne leÄe za odreÄivanje jednogodiÅ”njih organizama, dok se masa oÄne leÄe nije mogla uzeti kao pouzdana za odreÄivanje starosti
Dynamics of a close-loop controlled MEMS resonator
The dynamics of a close-loop electrostatic MEMS resonator, proposed as a platform for ultra sensitive mass sensors, is investigated. The parameter space of the resonator actuation voltage is investigated to determine the optimal operating regions. Bifurcation diagrams of the resonator response are obtained at five different actuation voltage levels. The resonator exhibits bi-stability with two coexisting stable equilibrium points located inside a lower and an upper potential wells. Steady-state chaotic attractors develop inside each of the potential wells and around both wells. The optimal region in the parameter space for mass sensing purposes is determined. In that region, steady-state chaotic attractors develop and spend most of the time in the safe lower well while occasionally visiting the upper well. The robustness of the chaotic attractors in that region is demonstrated by studying their basins of attraction. Further, regions of large dynamic amplification are also identified in the parameter space. In these regions, the resonator can be used as an efficient long-stroke actuator
Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms
Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood-brain barrier, bone marrow, heart, liver, lung, tumor, and vascular), with an emphasis on the critical role of stem cells in the synthesis of complex tissues. This study further recaps the design, fabrication, high-throughput performance, and improved functionality of stem-cell-based OOCs, technical challenges, obstacles against implementing their potential applications, and future perspectives related to different experimental platforms