43 research outputs found
Microlensing by natural wormholes: theory and simulations
We provide an in depth study of the theoretical peculiarities that arise in
effective negative mass lensing, both for the case of a point mass lens and
source, and for extended source situations. We describe novel observational
signatures arising in the case of a source lensed by a negative mass. We show
that a negative mass lens produces total or partial eclipse of the source in
the umbra region and also show that the usual Shapiro time delay is replaced
with an equivalent time gain. We describe these features both theoretically, as
well as through numerical simulations. We provide negative mass microlensing
simulations for various intensity profiles and discuss the differences between
them. The light curves for microlensing events are presented and contrasted
with those due to lensing produced by normal matter. Presence or absence of
these features in the observed microlensing events can shed light on the
existence of natural wormholes in the Universe.Comment: 16 pages, 24 postscript figures (3 coloured), revtex style, submitted
to Phys. Rev.
Lodged in the throat: Internal infinities and AdS/CFT
In the context of AdS3/CFT2, we address spacetimes with a certain sort of
internal infinity as typified by the extreme BTZ black hole. The internal
infinity is a null circle lying at the end of the black hole's infinite throat.
We argue that such spacetimes may be described by a product CFT of the form
CFT-L * CFT-R, where CFT-R is associated with the asymptotically AdS boundary
while CFT-L is associated with the null circle. Our particular calculations
analyze the CFT dual of the extreme BTZ black hole in a linear toy model of
AdS3/CFT2. Since the BTZ black hole is a quotient of AdS3, the dual CFT state
is a corresponding quotient of the CFT vacuum state. This state turns out to
live in the aforementioned product CFT. We discuss this result in the context
of general issues of AdS/CFT duality and entanglement entropy.Comment: 11 pages, 2 figures; v2 - some typos corrected, minor revision
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Bioactivity of aqueous extracts of Clibadium sylvestre (Aubl.) Baill. and Derris amazonica Killip on the aphid Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)
Comparing Problem Formulation for Coupled Sets of Component
In this paper several formulations and comparative test results are presented for problems involving the general paradigm of coupled sets of components. This paradigm is general enough to include systems of systems (SoS) and multidisciplinary design optimization (MDO). It is assumed that these systems involve a (potentially inactive) coordinating component, or "Central Authority" and one or more, potentially interacting, subordinate components. The formulations differ in the amount of control given to the central authority versus the autonomy granted to the subordinate components. Comparative test results are given for several of the formulations on a NASA-generated, public domain, aircraft conceptual design problem
A dispersion-optics model for calculating visibility impairment and comparisons of model estimates with field measurements
COMPARISON OF THE HAPLOTYPES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE RAT IV. THE SIX ORIGINAL AG-B HAPLOTYPES
A case of benign metastasizing leiomyoma: Pathobiological behavior showing a low-grade malignant potential
The ESPRIT Project CAFE - High Security Digital Payment Systems
. CAFE ("Conditional Access for Europe") is an ongoing project in the European Community's ESPRIT program. The goal of CAFE is to develop innovative systems for conditional access, and in particular, digital payment systems. An important aspect of CAFE is high security of all parties concerned, with the least possible requirements that they are forced to trust other parties (so-called multi-party security). This should give legal certainty to everybody at all times. Moreover, both the electronic money issuer and the individual users are less dependent on the tamper-resistance of devices than in usual digital payment systems. Since CAFE aims at the market of small everyday payments that is currently dominated by cash, payments are offline, and privacy is an important issue. The basic devices used in CAFE are so-called electronic wallets, whose outlook is quite similar to pocket calculators or PDAs (Personal Digital Assistant). Particular advantages of the electronic wallets are that PIN..