7 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
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- Amouyel Philippe
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- Universitat AutĂČnoma de Barcelona
- Uphill J.
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- Whitehead P.L.
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- Wilcock G.
- Wilhelmsen K.C.
- Williams A.
- Williams B.
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- Wong R.
- Woods B.
- Woon M.
- Wright C.B.
- Wu C.K.
- Wu Y.
- Xia T.h.
- Xu E.
- Xu F.
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Younkin S.G.
- Yu C.E.
- Yu L.
- Zare H.
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C.P.
- Zompo M.D.
- Zulaica M.
- Ălvarez V.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
AnĂĄlisis de una cohorte de pacientes con endocarditis infecciosa tratados con linezolid
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
- Author
- Abdulla Susanne
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Al-Chalabi Ammar
- Albus M.
- Alexander M.
- Amin Farooq
- Amouyel Philippe
- Andersen P.M.
- Andreassen Ole A.
- Andres Christian R.
- Anthony O'Neill F.
- Arcuti S.
- Bacanu S.A.
- Basak Nazli
- Bauer Denis
- Begemann M.
- Beghi E.
- Belliveau R.A.
- Bene J.
- Bensimon Gilbert
- Bergen Sarah E.
- Bertolin C.
- Bevilacqua E.
- Bigdeli Tim B
- Black D.W.
- Blackwood Douglas H. R.
- Blagojevic-Radivojkov Milena
- Blair I.
- Bo R.D.
- Bradley Daniel G.
- Bramon Elvira
- Breen G.
- Brice Alexis
- Brown R. H.
- Bruggeman R.
- Brunetti M.
- Buccola N.G.
- Buckner R.L.
- Bulik-Sullivan B.
- Buxbaum Joseph D.
- Byerley W.
- BĂžrglum Anders D.
- Cahn Wiepke
- Cai G.
- Calvo A.
- Campion D.
- Cantor R.M.
- Capozzo Rosa
- Carr Vaughan J
- Carrera N.
- Casale F.
- Catts S.V.
- Cereda C.
- Chambert K.D.
- Chan R.C.K.
- Chan R.Y.L.
- Chandran Siddharthan
- Chen E.Y.H.
- Cheng W.
- Cheung E.F.C.
- Chio A.
- Chong S.A.
- Cichon Sven
- Cloninger C.R.
- Cohen D.
- Cohen N.
- Collier D.A.
- Colville Shuna
- Comi G.P.
- Corcia P.
- Cormican P.
- Corvin A.
- Craddock N.
- Crowley J.J.
- Curtis Charles
- Curtis D.
- D'Alfonso S.
- Daly Mark J.
- Damme P.V.
- Dartigues Jean- François
- Darvasi Ariel
- Davidson M.
- Davis K.L.
- de Carvalho Mamede
- De Haan L.
- de Visser Marianne
- Degenhardt F.
- Dekker Annelot M.
- Demontis D.
- Diekstra Frank P.
- Dikeos D.
- Dinan T.
- Djurovic S.
- Domenici Enrico
- Donohoe G.
- Drapeau E.
- Drepper Carsten
- Duan J.
- Dudbridge F.
- Durmishi N.
- Durr Alexandra
- Eftimov Filip
- Ehrenreich Hannelore
- Eichhammer P.
- Elman Lauren B.
- Eriksson J.
- Es M.A.V.
- Escott-Price Valentina
- Esko TÔnu
- Essioux L.
- Estrada Karol
- Fanous A.H.
- Farh K.H.
- Farrell M.S.
- Favero J.D.
- Filosto M.
- Fogh Isabella
- Frank J.
- Franke Andre
- Franke L.
- Fratta Pietro
- Freedman R.
- Freimer N.B.
- Friedl M.
- Friedman J.I.
- Fromer M.
- Gejman Pablo V.
- Gellera C.
- Genovese G.
- Georgieva L.
- Giegling I.
- Gil Michael
- Giusti-RodrĂœguez P.
- Glass J.
- Godard S.
- Goldstein Jacqueline I.
- Golimbet V.
- Gopal S.
- Goris An
- Gratten J.
- Gurling Hugh
- Hammer C.
- Hamshere M.L.
- Hansen M.
- Hansen T.
- Hardiman Orla
- Hardy John
- Haroutunian V.
- Hartmann A.M.
- Henskens F.A.
- Herms S.
- Hirschhorn J.N.
- Hoffmann P.
- Hofman A.
- Hofman Albert
- Hollegaard M.V.
- Holmans P.A.
- Hong Lee S.
- Hougaard D.M.
- Huang H.
- Hultman Christina M.
- Ikeda M.
- Iwata Nakao
- Jablensky Assen V.
- Joa I.
- Jones Ashley R.
- Jonsson Erik G.
- Julia Antonio
- Kahler A.K.
- Kahlke Tim
- Kahn René S.
- Kalaydjieva L.
- Karachanak-Yankova S.
- Karjalainen J.
- Kavanagh D.
- Keller M.C.
- Kendler Kenneth S.
- Kennedy J.L.
- Khrunin A.
- Kiernan Matthew C.
- Kim Y.
- Kirov George
- Klovins J.
- Knight Jo
- Knowles J.A.
- Konte B.
- Kucinskas V.
- Kucinskiene Z.A.
- Kuzelova-Ptackova H.
- Landers John E
- Landwehrmeyer Georg Bernhard
- Laurent C.
- Lee J.
- Lee P.
- Legge S.E.
- Lencz Todd
- Lerer B.
- Levinson Douglas F.
- Lewis C.M.
- Li M.
- Li Qingqin S.
- Li T.
- Liang K.Y.
- Lichtner Peter
- Lieb Wolfgang
- Lieberman J.
- Limborska S.
- Lin Kuang
- Liu Jianjun
- Logroscino G.
- Lomen-Hoerth Catherine
- Lonnqvist J.
- Loughland C.M.
- Lubinski J.
- Ludolph A.C.
- Lunetta C.
- Luykx Jurjen J.
- MacEk M.
- Magnusson P.K.E.
- Maher B.S.
- Maier W.
- Malaspina Andrea
- Malhotra Anil K.
- Mallet J.
- Marsal Sara
- Mattheisen M.
- Mattingsdal M.
- Maurel Cindy
- Mazzini L.
- McCarley R.W.
- McCarroll Steven A.
- McCluskey Leo
- McDonald C.
- McIntosh A.M.
- McLaughlin Russell L.
- McQuillin Andrew
- Meier S.
- Meijer C.J.
- Meininger Vincent
- Meitinger Thomas
- Melegh B.
- Melle I.
- Mesholam-Gately R.I.
- Metspalu A.
- Meyer Thomas
- Michie P.T.
- Milani L.
- Milanova V.
- Millecamps Stéphanie
- Moglia C.
- Mokrab Y.
- Mora JesĂșs S.
- Moran Jennifer
- Morris D.W.
- Morrison Karen E.
- Mors O.
- Mortensen Preben Bo
- Mowry Bryan J.
- Muller-Myhsok B.
- Murphy K.C.
- Murray R.M.
- Myin-Germeys I.
- Neale B.M.
- Nelis M.
- Nenadic I.
- Nertney D.A.
- Nestadt G.
- Nicholson Garth A.
- Nicodemus K.K.
- Nigel Leigh P.
- Nikitina-Zake L.
- Nisenbaum L.
- Nordin A.
- Nothen Markus M.
- O'Brien Margaret
- O'Callaghan E.
- O'Donovan Michael C.
- O'Dushlaine C.
- Oh S.Y.
- Olincy A.
- Olsen L.
- Ophoff Roel A.
- Orrell Richard W.
- Owen Michael J.
- Padovani A.
- Palotie Aaron
- Pamphlett Roger
- Pansarasa O.
- Pantelis C.
- Papadimitriou G.N.
- Papiol S.
- Parkhomenko E.
- Pasterkamp R.J.
- Pato Carlos N.
- Pato M.T.
- Paunio T.
- Payan Christine A. M.
- Pejovic-Milovancevic M.
- Penco S.
- Pensato V.
- Perkins D.O.
- Pers T.H.
- Petri Susanne
- Petryshen Tracey L.
- Pietilainen O.
- Pimm J.
- Pinto Susana
- Pittman Alan
- Pocklington A.J.
- Polak Meraida
- Posthuma Danielle
- Powell J.
- Price A.
- Pulit Sara L.
- Pulver A.E.
- Pupillo E.
- Purcell S.M.
- Quested D.
- Rasmussen H.B.
- Ratti A.
- Reichenberg A.
- Reimers M.A.
- Richards A.L.
- Rietschel Marcella
- Riley Brien Patrick
- Ripke S.
- Riva N.
- Rivadeneira Fernando
- Robberecht W.
- Roffman J.L.
- Rojas-Garcia Ricard
- Roussos P.
- Rowe Dominic B.
- Ruderfer D.M.
- Rujescu Dan
- Saker-Delye Safa
- Salachas François
- Salomaa V.
- Sanders A.R.
- Schall U.
- Schijven Dick
- Schubert C.R.
- Schulze T.G.
- Schwab S.G.
- Scolnick E.M.
- Scott Stroup T.
- Scott R.J.
- Seidman L.J.
- Sendtner Michael
- Sham Pak C.
- Shatunov Aleksey
- Shaw Christopher
- Shaw Pamela
- Shi J.
- Sidle Katie
- Sigurdsson E.
- Silagadze T.
- Silani V.
- Silverman J.M.
- Sim K.
- Sklar Pamela
- Slominsky P.
- Smith B.N.
- Smoller J.W.
- So H.C.
- Soraru G.
- Spencer C.C.A.
- Sproviero William
- St Clair David
- Stah E.A.
- Stefansson H.
- StefĂĄnsson KĂĄri
- Steinberg S.
- Stogmann E.
- Straub R.E.
- Strengman E.
- Strohmaier J.
- Subramaniam M.
- Sullivan Patrick F.
- Suvisaari J.
- Svrakic D.M.
- Swingler Robert
- Szatkiewicz J.P.
- Söderman E.
- Thirumalai S.
- Ticozzi Nicola
- Tiloca C.
- Tittmann Lukas
- Toncheva D.
- Tortelli R.
- Tosato S.
- Trojanowski John Q.
- Tzourio Christophe
- Uitterlinden André G.
- Universitat AutĂČnoma de Barcelona
- van Deerlin Vivianna M.
- van den Berg Leonard H.
- van der kooi Anneke Jelly
- van der Spek Rick A.A.
- van Doormaal Perry TC.
- Van Eijk Kristel R.
- van Rheenen Wouter
- Vanos J.
- Veijola J.
- Veldink Jan
- Visscher PM
- Vourc'H P.
- Waddington J.
- Walsh D.
- Walters J.T.R.
- Wang D.
- Wang Q.
- Webb B.T.
- Weber Markus
- Weinberger Daniel R.
- Weiser Mark
- Weishaupt J.H.
- Wendland Jens
- Werge Thomas
- Wiedau-Pazos Martina
- Wildenauer Dieter B.
- Williams Kelly
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wood Nicholas
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin S.
- Zai Clement C.
- Zecca C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 Ă 10) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 Ă 10). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies
Development and validation of a methodology for the sensometric characterisation of highâpungency peppers: a case study of habanero pepper ( Capsicum chinense
- Author
- Addinsoft
- AdĂĄn CabalâPrieto
- CastellĂłnâMartĂnez E.
- Dos SantosâGarruti D.
- Emmanuel de JesĂșs RamĂrezâRivera
- Hutchinson S.E.
- Ingrid Mayanin RodriguezâBuenfil
- ISO 11035
- ISO 3513â1977
- ISO Standard 10399
- ISO Standard 16820
- ISO Standard 4120
- ISO Standard 5496
- ISO Standard 8586â1
- JosĂ© AndrĂ©s HerreraâCorredor
- Julio Enrique OneyâMontalvo
- JuĂĄrezâBarrientos J.M.
- KyungâHyung K.
- Manuel Octavio RamĂrezâSucre
- Mirielen PĂ©rezâRobles
- Patel K.
- R Core Team
- SolleiroâRebolledo J.L.
- SĂĄnchezâSĂĄnchez H.
- Witoon Prinyawiwatkul
- ZamaconaâRuiz M.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F): Exploratory and confirmatory factor analyses at item level
- Author
- A. B. G. Berbén
- B. OâConnor
- B. Thompson
- B.G. Tabachnick
- C.A. Christensen
- D. Kember
- D. Kember
- D. Kember
- D. Rindskopf
- D.B. Flora
- D.W. Russell
- F. Cano
- F. Marton
- F. Marton
- Fernando Justicia
- Francisco Cano
- H.F. Kaiser
- H.G. Wolff
- J. Biggs
- J. Biggs
- J. Biggs
- J. Biggs
- J. Biggs
- J. Biggs
- J. Biggs
- J. Hattie
- J. Sach
- J. Schmid
- J.H.F. Meyer
- J.H.F. Meyer
- J.L. Horn
- J.T.E. Richardson
- J.T.E. Richardson
- JesĂșs De la Fuente
- K. Kelloway
- K.A. Bollen
- K.G. Jöreskog
- K.G. Jöreskog
- K.G. Jöreskog
- L. RodrĂguez
- M. Carmen Pichardo
- M. Prosser
- M.J. OâNeil
- N. Entwistle
- N. Entwistle
- P.C. Burnet
- R.A. Fox
- R.B. Kline
- R.K. Henson
- R.L. Gorsuch
- S.E. Volet
- W.F. Velicer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nanomedicine
- Author
- A. Quintana
- A.S. Chauhan
- B. Dubertret
- D. Garrec Le
- D.W. Cagle
- E. Blanco
- E. Ruoslahti
- F. Bedioui
- F. Curnis
- F.A. Mumpton
- F.D. Hong
- G. Lambert
- G.M. Whitesides
- H. Cohen-Sacks
- H. Nakanishi
- H. Otsuka
- H. Xu
- J.D. Hood
- J.H. Choy
- J.Z. Hilt
- K. Ewert
- K. Pavelic
- K.E. Orosz
- K.M. Ravi
- K.M. Ravi
- K.M. Tyner
- K.S. Oh
- M. Essler
- M. Liu
- M.E. Akerman
- N. Csaba
- N. Nishiyama
- NanoMarkets
- O.L. Padilla De JesĂșs
- P. Laakkonen
- P. Laakkonen
- R.A. Freitas Jr
- R.M. Schiffelers
- S. Fernandez-Lopez
- S. Foley
- S. Kraljevic
- S. Zhang
- S.E. Striba
- S.H. Friedman
- S.M. Auerbach
- S.S. Davis
- S.Y. Kwak
- S.Y. Kwak
- T. Merdan
- T. Ooya
- T.C. Holmes
- T.I. Kim
- X. Wu
- Y. Chen
- Y. Choi
- Y. Dong
- Y. Shin
- Z. Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)