10 research outputs found
Detectable clonal mosaicism and its relationship to aging and cancer
- Author
- Abnet C.C. (Christian C.)
- Ahlbom A. (Anders)
- Albanes D. (Demetrius)
- Aldrich M.C. (Melinda C.)
- Amos C. (Christopher)
- Amundadottir L. (Laufey)
- Andersson U. (Ulrika)
- Andrulis I.L. (Irene L.)
- Arslan A.A. (Alan A.)
- Baris D. (Dalsu)
- Barkauskas D.A. (Donald A.)
- Beane-Freeman L.E. (Laura E.)
- Berg C.D. (Christine D.)
- Berndt S.I. (Sonja I.)
- Bertazzi P.A. (Pier Alberto)
- Black A. (Amanda)
- Blot W.J. (William J.)
- Bock C.H. (Cathryn H.)
- Boutron-Ruault M.C. (Marie-Christine)
- Bracci P.M. (Paige M.)
- Brinton L.A. (Louise A.)
- Bueno-de-Mesquita H.B. (H. Bas)
- Burdett L. (Laurie)
- Buring J.E. (Julie E.)
- Butler M.A. (Mary A.)
- Canzian F. (Federico)
- Caporaso N.E. (Neil E.)
- Carreon T. (Tania)
- Chang K. (Kenneth)
- Chanock S.J. (Stephen J.)
- Chatterjee N. (Nilanjan)
- Chow W.H. (Wong-Ho)
- Chung C.C. (Charles C.)
- Consonni D. (Dario)
- Cook M.B. (Michael B.)
- Cotterchio M. (Michelle)
- Cullen M. (Michael)
- Davis F.G. (Faith G.)
- Dean M.C. (Michael C.)
- Deng X. (Xiang)
- Ding T. (Ti)
- Duell E.J. (Eric J.)
- Elena J.W. (Joanne W.)
- Epstein C.G. (Caroline G.)
- Erickson R.L. (Ralph L.)
- Fan J.H. (Jin-Hu)
- Feychting M. (Maria)
- Figueroa J.D. (Jonine D.)
- Fraumeni J.F. (Joseph F.)
- Freedman N.D. (Neal D.)
- Fuchs C.S. (Charles S.)
- Gallinger S. (Steven)
- Gao Y.T. (Yu-Tang)
- Gapstur S.M. (Susan M.)
- Garcia-Closas M. (Montserrat)
- Gaudet M.M. (Mia M.)
- Gaziano J.M. (J. Michael)
- Giles G.G. (Graham G.)
- Gillanders E.M. (Elizabeth M.)
- Giovannucci E.L. (Edward L.)
- Goggins M. (Michael)
- Goldin L. (Lynn)
- Goldstein A.M. (Alisa M.)
- Gonzalez J.R. (Juan R.)
- Gorlick R.G. (Richard G.)
- Graubard B.I. (Barry I.)
- Greene M.H. (Mark H.)
- Gross M.D. (Myron D.)
- Haiman C.A. (Christopher A.)
- Hallmans G. (Goran)
- Hankinson S.E. (Susan E.)
- Harris C.C. (Curtis C.)
- Hartge P. (Patricia)
- Hassan M. (Manal)
- Henderson B.E. (Brian E.)
- Henriksson R. (Roger)
- Hoffman-Bolton J.A. (Judith A.)
- Holly E.A. (Elizabeth A.)
- Hoover R.N. (Robert N.)
- Horner M.J. (Marie-Josephe)
- Hsing A.W. (Ann W.)
- Hu N. (Nan)
- Hunter D.J. (David J.)
- Hutchinson A. (Amy)
- Inskip P.D. (Peter D.)
- Jacobs K. (Kevin)
- Jenab M. (Mazda)
- Jiao L. (Li)
- Johansen C. (Christoffer)
- Johnson A. (Alison)
- Khaw K.T. (Kay-Tee)
- Klein A.P. (Alison P.)
- Kogevinas M. (Manolis)
- Koh W.P. (Woon-Puay)
- Kolonel L.N. (Laurence N.)
- Kooperberg C. (Charles)
- Kovaks J. (Joseph)
- Kraft P. (Peter)
- Kratz C.P. (Christian P.)
- Krogh V. (Vittorio)
- Kurtz R.C. (Robert C.)
- LaCroix A. (Andrea)
- Landgren A. (Annelie)
- Landi M.T. (María Teresa)
- Le-Marchand L. (Loic)
- Li D. (Donghui)
- Liao L. (Linda)
- Lissowska J. (Jolanta)
- Liu C. (Chenwei)
- Malats N. (Nuria)
- Mandelson M.T. (Margaret T.)
- Marenne G. (Gaelle)
- McGlynn K.A. (Katherine A.)
- McKean-Cowdin R. (Roberta)
- McNeill L.H. (Lorna H.)
- McWilliams R.R. (Robert R.)
- Melin B.S. (Beatrice S.)
- Mendelsohn J.B. (Julie B.)
- Michaud D.S. (Dominique S.)
- Mirabello L. (Lisa)
- Moore L.E. (Lee E.)
- Olson S.H. (Sara H.)
- Patiño-García A. (Ana)
- Peplonska B. (Beata)
- Perez-Jurado L.A. (Luis A.)
- Peters U. (Ulrike)
- Petersen G. (Gloria)
- Prokunina-Olsson L. (Ludmila)
- Purdue M. (Mark)
- Qiao Y.L. (You-Lin)
- Rabe K.G. (Kari G.)
- Rajaraman P. (Preetha)
- Real F.X. (Francisco X.)
- Riboli E. (Elio)
- Risch H.A. (Harvey A.)
- Rodriguez-Santiago B. (Benjamin)
- Rothman N. (Nathaniel)
- Rotunno M. (Melissa)
- Ruder A.M. (Avima M.)
- Rybicki B.A. (Benjamin A.)
- Sampson J. (Joshua)
- Savage S.A. (Sharon A.)
- Schumacher F. (Fredrick)
- Schwartz A.G. (Ann G.)
- Schwartz K.L. (Kendra L.)
- Schwenn M. (Molly)
- Sesso H.D. (Howard D.)
- Severi G. (Gianluca)
- Shu X.O. (Xiao-Ou)
- Sierrasesumaga L. (Luis)
- Signorello L.B. (Lisa B.)
- Silverman D.T. (Debra T.)
- Spitz M.R. (Margaret R.)
- Stevens V.L. (Victoria L.)
- Stolzenberg-Solomon R.Z. (Rachael Z.)
- Stram D. (Daniel)
- Tang Z.Z. (Ze-Zhong)
- Taylor P.R. (Philip R.)
- Teras L.R. (Lauren R.)
- Thomas G. (Gilles)
- Tjonneland A. (Anne)
- Tobias G.S. (Geoffrey S.)
- Trichopoulos D. (Dimitrios)
- Tucker M. (Margaret)
- Villa O. (Olaya)
- Virtamo J. (Jarmo)
- Visvanathan K. (Kala)
- Wacholder S. (Sholom)
- Wang Z. (Zhaoming)
- Weinstein S.J. (Stephanie J.)
- Wentzensen N. (Nicolas)
- Wheeler W. (William)
- White E. (Emily)
- Wiencke J.K. (John K.)
- Wolk A. (Alicja)
- Wolpin B.M. (Brian M.)
- Wrensch M. (Margaret)
- Wu Y.Q. (Yan Q.)
- Wunder J.S. (Jay S.)
- Xiang Y.B. (Yong-Bing)
- Yeager M. (Meredith)
- Yu H. (Herbert)
- Yu K. (Kai)
- Yuan J.M. (Jian-Min)
- Zanetti K.A. (Krista A.)
- Zeleniuch-Jacquotte A. (Anne)
- Zheng W. (Wei)
- Zhou W. (Weiyin)
- Ziegler R.G. (Regina G.)
- Publication venue
- Nature Publishing Group
- Publication date
- 01/12/2012
- Field of study
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases
Volatile Oil Composition and Antiplatelet Activity of Jordanian Achillea biebersteinii
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
On Two Equivalent Dilation Theorems in VH-Spaces
- Author
- A. Inoue
- A. Weron
- Aurelian Gheondea
- B. Sz.-Nagy
- Baris Evren Ugurcan
- D. Gaşpar
- E. Effros
- E.B. Davies
- E.C. Lance
- F.H. Szafraniec
- G.G. Kasparov
- I. Kaplansky
- J. Dixmier
- J.B. Conway
- M. Hayashi
- M.A. Naĭmark
- M.A. Naĭmark
- M.A. Rieffel
- N.C. Phillips
- R.M. Loynes
- R.M. Loynes
- S.A. Chobanyan
- V.R. Paulsen
- W.A. Arveson
- W.F. Stinespring
- W.L. Paschke
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of the Dads for Life Intervention on Interparental Conflict and Coparenting in the Two Years After Divorce
- Author
- Adamsons K.
- Ahrons C.R.
- Baris M.A.
- Braver S.L.
- Braver S.L.
- Braver S.L.
- Cookston J.T.
- Curran P.J.
- Douglas E.M.
- Ersner-Hershfield R.
- Geasler M.J.
- Geelhoed R.J.
- Hetherington E.M.
- Hurlbert D.F.
- Jackson K.M.
- Johnston J.R.
- Kramer K.M.
- Maccoby E.E.
- Mayer G.S.
- McKenry P.C.
- Oakland T.
- Sbarra D.A.
- Sullivan M.J.
- U.S. Bureau of the Census
- Vandervalk I.
- Whiteside M.F.
- Wolchik S.A.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)
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- Abd-El Aziz M. Gamal
- Abdilaahi A.A.
- Abilova S.
- Adamson D.
- Ahamed N.
- Ahanya S.N.
- Ahmed C.M.
- Ain Al
- Akbar R.
- Al bakshi F.
- Al Hatou E.I.
- Al Mulla A.
- Al-Hussein A.
- Al-Saedi G.
- Al-Yousuf L.
- AlBayati M.
- Aldridge E.
- AlHaidari T.
- Ali L. Ait
- Ali M.
- Almahmeed W.A.R.
- Ambrus N.
- Anastasiou-Nana M.
- Ang H.L.
- Ansari-Ramandi M.M.
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- Aprami T.M.
- Aquieri A.
- Arrigo M.
- Arstall M
- Arstall Margaret
- Ashour Z.
- Askar A.O.
- Assenza G. Egidy
- Bahshaliyev A.
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- Baris L.
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- Bazargani N.
- Beckx M.
- Begum F.
- Bekiaris G.
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- Berger F.
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- Calcagnino M.
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- Clade S.
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- Žaliūnas R.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Assessment of Palliative Care in Lung Cancer in Turkey
- Author
- A. Bahadir
- A. Dalli
- A. Senturk
- A. Ulas
- A.E. Erbaycu
- B. Kerget
- B.A. Ozyurek
- D. Tatar
- D.M. Yavsan
- F. Talay
- G. Cakmak
- G. Kirkil
- H. Can
- H. Esme
- H. Gunbatar
- H.S. Sen
- I. Basyigit
- L. Saglam
- L.C. Mutlu
- M. Acat
- M. Beşiroğlu
- M. Ozcelik
- M.M. Erol
- M.O. Akbay
- N. Ozcelik
- O. Oruc
- P.F. Yumuk
- S. Arinc
- S. Asker
- S. Berk
- S. Erol
- S. Ozkurt
- S.A. Baris
- S.O. Ayik
- T. Kilic
- T. Ozlu
- T. Teke
- U. Toru
- U. Yilmaz
- Y. Bülbül
- Y. Erdoğan
- Y.S. Intepe
- Z.A. Yasar
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
Molecular Markers of Caspase-Dependent and Mitochondrial Apoptosis: Role in the Development of Pathology and Cellular Senescence
- Author
- A. Pustavoitau
- A.A. Novik
- A.B. Salmina
- A.P. Read
- A.V. Gordeeva
- A.V. Shirokova
- A.Yu. Baryshnikov
- B. Farina
- B. Lewin
- B. Mahata
- B. Uyanik
- C. Ising
- C.-F. Chiu
- C.H. Lin
- D. Pastore
- D.J. Baker
- D.R. McIlwain
- E. Hangen
- E.A. Martynova
- E.M. Creagh
- F. Bucchieri
- F. Bunz
- F. Li
- G. Wu
- G.P. Dotto
- G.P. Kaushal
- H.B. Yang
- H.S. Madapura
- I. Hasan
- J. Krishnamurthy
- J. Li
- J. Liu
- J.A. Klein
- J.F.R. Kerr
- J.G. Rheinwald
- J.Y. Lee
- K. Bedelbaeva
- K. Mishiro
- L. Daszkiewicz
- L. Salmena
- M.G. Kolonin
- M.P. Potapnev
- M.T. Coughlan
- M.Y. Ho
- N. Nagy
- N. Vahsen
- O.R. Baris
- S. Milasta
- S.A. Susin
- S.E. Thal
- S.V. Ryzhov
- T. Eleftheriadis
- V.D. Samuilov
- W.H. Liggett
- Y. Koizumi
- Y.T. Peng
- Z.-J. Li
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
Mesothelioma
- Author
- A. Andrion
- A. Burke
- A. Churg
- A. Churg
- A. Churg
- A. Churg
- A. Churg
- A. Churg
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- A. Churg
- A. Churg
- A. Dawson
- A. DeLuca
- A. Dewar
- A. Dufresne
- A. Hirvonen
- A. Karjalainen
- A. Naramoto
- A. Stout
- A. Talerman
- A.A. Renshaw
- A.D. McDonald
- A.D. McDonald
- A.D. McDonald
- A.D. McDonald
- A.D. McDonald
- A.E. Fraire
- A.E. Fraire
- A.G. Montag
- A.I. Neugut
- A.N. Rohl
- A.P. Chahinian
- A.P. Chahinian
- A.P. Soler
- A.P. Soler
- A.R. Gibbs
- A.S.Y. Leong
- B. Beck
- B. Corrin
- B. Gilks
- B. Jarvholm
- B. Jasani
- B. Leeuw De
- B. Lin
- B. Risberg
- B. Waxler
- B.I. Castleman
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- C. Boutin
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- D.A. Ferguson
- D.B. MacDougall
- D.H. Dail
- D.H.K. Lee
- D.J. Sugarbaker
- D.R. Taylor
- D.S. Cooke
- D.W. Henderson
- D.W. Henderson
- E. Alexander
- E. Gaertner
- E. Hain
- E. Piccigallo
- E. Plas
- E. Wagner
- E.E. Keal
- E.G. Butchart
- E.H. Marom
- E.H. Zeren
- E.I. Kahn
- F. Gallateau-Salle
- F.D. Pooley
- F.G. Mayall
- F.H.Y. Green
- F.N. Ghadially
- F.P. Li
- G. Fine
- G. Hillerdal
- G. Hillerdal
- G. Klein
- G. Roberts
- G. Serio
- G. Sheers
- G.A. Blobel
- G.A. Nascimento
- G.F. Rubino
- G.L. Ceresoli
- G.N.P. Muijen van
- G.R. Armstrong
- H. Battifora
- H. Battifora
- H. Loosli
- H. Monaghan
- H. Nishioka
- H. Nomori
- H. Otto
- H. Pass
- H.D. Gossinger
- H.D. Strickler
- H.D. Strickler
- H.E. Robertson
- H.J. Lerner
- H.S.R. Malker
- H.T. Lynch
- H.W. Wedler
- I. Dardick
- I. Dardick
- I. McEwen
- I. Roushdy-Hammady
- I.J. Selikoff
- I.M. Sopher
- J. Aisner
- J. Churg
- J. Dunnigan
- J. Goldblum
- J. Holden
- J. Linder
- J. Metzger
- J. Peto
- J. Ribak
- J. Rosai
- J. Talcott
- J.B. Taxy
- J.C. McDonald
- J.C. McDonald
- J.C. Wagner
- J.C. Wagner
- J.E. Craighead
- J.E. Craighead
- J.E. Craighead
- J.E. Craighead
- J.E. Herndon
- J.G. Edwards
- J.G. Lorigan
- J.H. Moore
- J.H. Shanks
- J.I. Epstein
- J.M. Corson
- J.M. Corson
- J.M.G. Davis
- J.M.G. Davis
- J.P.C. Steele
- J.P.C. Steele
- J.R. Edge
- J.R. Riera
- J.R. Testa
- J.S. Reis-Filho
- J.T. Hodgson
- J.T. Peterson
- J.W. Bolen
- K. Antman
- K. Antman
- K. Antman
- K. Browne
- K. Browne
- K. Sheibani
- K. Sheibani
- K. Sheibani
- K. Solomons
- K.A. Anderson
- K.E. Otte
- K.H. Antman
- K.H. Antman
- K.H. Antman
- K.H. Antman
- K.J. Butnor
- K.M. Wolf
- L. Coplu
- L. Japko
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- L. Weissman
- L.E. Nochomowitz
- M. Andersson
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- M. Kannerstein
- M. Kannerstein
- M. Klima
- M. Koss
- M. Melato
- M. Miettinen
- M. Miettinen
- M. Praet
- M. Santucci
- M. Takeichi
- M.-C. Aubry
- M.A. Jones
- M.A. Khan
- M.B. Austin
- M.B. Schenker
- M.C.P. Barberis
- M.J. Llewellyn
- M.J. Ross
- M.J. Warhol
- M.J. Warhol
- M.L. Newhouse
- M.P. Lefebvre
- M.P.G. Leers
- M.R. Becklake
- M.R. Wick
- N. Shivapurkar
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.G. Ordonez
- N.J. Nelson
- N.O. Whitley
- N.S. Wang
- N.S. Wang
- National Cancer Institute
- National Research Council
- O. Greengard
- P. Caccioti
- P. Cagle
- P. Chu
- P. Elmes
- P. Klemperer
- P. Rizzo
- P. Ruffie
- P. Sebastien
- P.A. Bejarano
- P.C. Elmes
- P.G. Chu
- P.H. Sugarbaker
- P.J. Zhang
- P.M. Cury
- P.T. Cagle
- R. Cantin
- R. Hubner
- R. Maurer
- R. Mennemeyer
- R. Spirtas
- R. Spirtas
- R. Thompson
- R.H. Newman
- R.H. Riddell
- R.J. Driscoll
- R.J. Marshall
- R.L. Attanoos
- R.L. Attanoos
- R.L. Zielhuis
- R.N. Harrison
- R.R. Connelly
- S. Mirvis
- S. Toyoka
- S.A. Sahn
- S.A. Yousem
- S.A.J. Kerrigan
- S.P. Hammar
- S.P. Hammar
- S.P. Hammar
- S.P. Hammar
- S.P. Kops
- S.R. Gloyne
- S.W. Weiss
- S.W. Weiss
- T. Ashcroft
- T. Fukuda
- T. Machin
- T. Nishikimi
- T.A. Sporn
- T.B. Crotty
- T.B. Mallory
- T.D. Oury
- T.F. Mancuso
- T.J. Winslow
- T.M. Mukherjee
- T.R. Burns
- T.R. Burns
- T.R. Harwood
- U. Latza
- V. Barbera
- V.I. Adams
- V.I. Adams
- V.J. Obers
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.L. Roggli
- V.W. Rusch
- W.D. Travis
- W.E. Mangano
- W.R. Jandik
- W.T. Vigneswaran
- W.T.E. McCaughey
- W.T.E. McCaughey
- Y. Pilatte
- Y. Suzuki
- Y.L. Baris
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Detectable clonal mosaicism and its relationship to aging and cancer
- Author
- Abnet C.C. (Christian C.)
- Ahlbom A. (Anders)
- Albanes D. (Demetrius)
- Aldrich M.C. (Melinda C.)
- Amos C. (Christopher)
- Amundadottir L. (Laufey)
- Andersson U. (Ulrika)
- Andrulis I.L. (Irene L.)
- Arslan A.A. (Alan A.)
- Baris D. (Dalsu)
- Barkauskas D.A. (Donald A.)
- Beane-Freeman L.E. (Laura E.)
- Berg C.D. (Christine D.)
- Berndt S.I. (Sonja I.)
- Bertazzi P.A. (Pier Alberto)
- Black A. (Amanda)
- Blot W.J. (William J.)
- Bock C.H. (Cathryn H.)
- Boutron-Ruault M.C. (Marie-Christine)
- Bracci P.M. (Paige M.)
- Brinton L.A. (Louise A.)
- Bueno-de-Mesquita H.B. (H. Bas)
- Burdett L. (Laurie)
- Buring J.E. (Julie E.)
- Butler M.A. (Mary A.)
- Canzian F. (Federico)
- Caporaso N.E. (Neil E.)
- Carreon T. (Tania)
- Chang K. (Kenneth)
- Chanock S.J. (Stephen J.)
- Chatterjee N. (Nilanjan)
- Chow W.H. (Wong-Ho)
- Chung C.C. (Charles C.)
- Consonni D. (Dario)
- Cook M.B. (Michael B.)
- Cotterchio M. (Michelle)
- Cullen M. (Michael)
- Davis F.G. (Faith G.)
- Dean M.C. (Michael C.)
- Deng X. (Xiang)
- Ding T. (Ti)
- Duell E.J. (Eric J.)
- Elena J.W. (Joanne W.)
- Epstein C.G. (Caroline G.)
- Erickson R.L. (Ralph L.)
- Fan J.H. (Jin-Hu)
- Feychting M. (Maria)
- Figueroa J.D. (Jonine D.)
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- Gaudet M.M. (Mia M.)
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- Gillanders E.M. (Elizabeth M.)
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- Goldstein A.M. (Alisa M.)
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- Severi G. (Gianluca)
- Shu X.O. (Xiao-Ou)
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- Stram D. (Daniel)
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- Xiang Y.B. (Yong-Bing)
- Yeager M. (Meredith)
- Yu H. (Herbert)
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- Ziegler R.G. (Regina G.)
- Publication venue
- Nature Publishing Group
- Publication date
- 01/12/2012
- Field of study
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases