69 research outputs found
The importance of major mergers in the build up of stellar mass in brightest cluster galaxies at z=1
Recent independent results from numerical simulations and observations have
shown that brightest cluster galaxies (BCGs) have increased their stellar mass
by a factor of almost two between z~0.9 and z~0.2. The numerical simulations
further suggest that more than half this mass is accreted through major
mergers. Using a sample of 18 distant galaxy clusters with over 600
spectroscopically confirmed cluster members between them, we search for
observational evidence that major mergers do play a significant role. We find a
major merger rate of 0.38 +/- 0.14 mergers per Gyr at z~1. While the
uncertainties, which stem from the small size of our sample, are relatively
large, our rate is consistent with the results that are derived from numerical
simulations. If we assume that this rate continues to the present day and that
half of the mass of the companion is accreted onto the BCG during these
mergers, then we find that this rate can explain the growth in the stellar mass
of the BCGs that is observed and predicted by simulations. Major mergers
therefore appear to be playing an important role, perhaps even the dominant
one, in the build up of stellar mass in these extraordinary galaxies.Comment: 15 pages, 6 figures, accepted for publication in MNRAS. Reduced data
will be made available through the ESO archiv
The Importance of Major Mergers in the Build Up of Stellar Mass in Brightest Cluster Galaxies at \u3cem\u3ez\u3c/em\u3e = 1
Recent independent results from numerical simulations and observations have shown that brightest cluster galaxies (BCGs) have increased their stellar mass by a factor of almost 2 between z ∼ 0.9 and z ∼ 0.2. The numerical simulations further suggest that more than half this mass is accreted through major mergers. Using a sample of 18 distant galaxy clusters with over 600 spectroscopically confirmed cluster members between them, we search for observational evidence that major mergers do play a significant role. We find a major merger rate of 0.38 ± 0.14 mergers per Gyr at z ∼ 1. While the uncertainties, which stem from the small size of our sample, are relatively large, our rate is consistent with the results that are derived from numerical simulations. If we assume that this rate continues to the present day and that half of the mass of the companion is accreted on to the BCG during these mergers, then we find that this rate can explain the growth in the stellar mass of the BCGs that is observed and predicted by simulations. Major mergers therefore appear to be playing an important role, perhaps even the dominant one, in the build up of stellar mass in these extraordinary galaxies
Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGFβ Receptor Kinase in Breast Cancer Cells
Tumor development, growth, and metastasis depend on the provision of an adequate vascular supply. This can be due to regulated angiogenesis, recruitment of circulating endothelial progenitors, and/or vascular transdifferentiation. Our previous studies showed that retinoic acid (RA) treatment converts a subset of breast cancer cells into cells with significant endothelial genotypic and phenotypic elements including marked induction of VE-cadherin, which was responsible for some but not all morphological changes. The present study demonstrates that of the endothelial-related genes induced by RA treatment, only a few were affected by knockdown of VE-cadherin, ruling it out as a regulator of the RA-induced endothelial genotypic switch. In contrast, knockdown of the RA-induced gene COUP-TFII prevented the formation of networks in Matrigel but had no effect on VE-cadherin induction or cell fusion. Two pan-kinase inhibitors markedly blocked RA-induced VE-cadherin expression and cell fusion. However, RA treatment resulted in a marked and broad reduction in tyrosine kinase activity. Several genes in the TGFβ signaling pathway were induced by RA, and specific inhibition of the TGFβ type I receptor blocked both RA-induced VE-cadherin expression and cell fusion. Together these data indicate a role for the TGFβ pathway and COUP-TFII in mediating the endothelial transdifferentiating properties of RA
Significance of renin and aldosterone in cirrhotic patients receiving spironolactone and furosemide
To improve nutrition of head and neck (H&N) cancer patients receiving radical radiotherapy (RT) in an outpatient setting by establishing a nasogastric (NG) feeding service to reduce lengthy inpatient stays and improve patient outcomes
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