A Peer-to-Peer Agent Auction

In this work we examine a peer-to-peer agent continuous double auction. We compare agents trading using peer-to-peer communications with agents using the same trading strategy in an auction that makes use of a centralized auctioneer to disseminate information. We present simulation data for these two auctions running with 2,500 to 160,000 agents. We find that the peer-to-peer auction is able to display price convergence behavior similar to that of the centralized auction. Further, the data shows that the peer-to-peer system has a constant cost in the number of message rounds needed to find the market equilibrium price as the number of traders is increased, in contrast to the linear cost incurred by the central auctioneer. Considering the above message costs, the peer-to-peer system outperformed the simple central auction by at least 100 times in our simulations. We further calculate that for a distributed hierarchical set of auctioneers, for which the message rounds cost of finding equilibrium are reduced to logarithmic in the number of traders, the peer-to-peer system will still produce better performance for systems with more than 5,000 traders

An extension of Lorentz's almost convergence and applications in Banach spaces

2000 Mathematics Subject Classification: Primary 40C99, 46B99.We investigate an extension of the almost convergence of G. G. Lorentz requiring that the means of a bounded sequence converge uniformly on a subset M of N. We also present examples of sequences α∈ l∞(N) whose sequences of translates (Tn α)n≥ 0 (where T is the left-shift operator on l∞(N)) satisfy: (a) Tn α, n ≥ 0 generates a subspace E(α) of l∞(N) that is isomorphically embedded into c0 while α is not almost convergent. (b) Tn α, n ≥ 0 admits an l1-subsequence and a nontrivial weakly Cauchy subsequence while a is almost convergent. Finally we show that, in the sense of measure, for almost all real sequences taking values in a compact set K ⊆ R (with at least two points), the sequence (Tn α)n ≥ 0 is equivalent in the supremum norm to the usual l1-basis and (hence) not almost convergent

Laparoscopic totally extraperitoneal inguinal hernia repair in the elderly: A prospective control study

Inguinal hernia (IH) repair can be obtained with both open and laparoscopic techniques, which are usually performed using a transabdominal preperitoneal (TAPP) or a totally extraperitoneal (TEP) approach. The aim of the study was to evaluate whether the results of laparoscopic TEP IH repair in the elderly ( 6565 years old) are different with respect to results obtained in younger patients. One hundred and four consecutive patients (four women and 100 men, median age of 57 years, range=21-85 years) with unilateral (N=21, 20.2%) or bilateral (N=83, 79.8%) IH were prospectively enrolled in the study. Patients were divided into two groups according to their age: group A (N=68, 65.4%) aged <65 years and group B (N=36, 34.6%) aged 6565 years. The mean operative time was not significantly different between groups (48\ub120 vs. 52\ub120 min, p=0.33). One case of increased PaCO2 was observed in each group (p=0.72) and two and one case of pneumoperitoneum (p=0.57) in groups A and B, respectively. Two (1.9%) patients (one in each group; p=0.55) required TEP conversion. Mild postoperative complications developed in four patients of each group (p=0.44). After one-year follow-up, three (2.9%) recurrences occurred (group 1=1, group 2=2, p=0.55), both in patients who had undergone direct IH repair. The overall postoperative relative risk of complications related to age was 1.08 (95% confidence interval=0.91-1.27, p=0.53). In conclusion, our results suggest that in patients with IH scheduled for TEP repair, age does not represent a contraindication to surgery in terms of complication rate and postoperative results

IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-γ occurs via the G-protein pathway

Major histocompatibility complex (MHC) class II antigen expression has been implicated in the pathogenesis of autoimmune type 1 diabetes. In this study we examined the role of various cytoldnes that may induce MHC class II surface antigen expression, using the rat insulinoma line RIN-5AH as a pertinent model system. As in another study, the ability of IFN-γ to amplify MHC class II antigen expression 4-fold is demonstrated. At the same time we noted a 5-fold increase of these histocompatibility antigens by IL-6. Signal transduction analysis reveals that IL-6-induced MHC class II expression is specifically mediated by the G-protein system (activation of p21ras by IL-6) since mevalonic acid lactone (a Gprotein inhibitor) abolishes the action of IL-6. In contrast, IFN-γ, which does not activate p21ras, is not inhibited by protein kinase C (PKC) inhibitors but by those of the G-protein pathway. This finding raises the possibility that IFN-γ induces RIN cells to secrete IL-6 (as shown previously, as well as in this paper) which, in turn, increases class II antigen expression via the G-protein pathway. This action may be unique to IL-6 or in synergy with IFN-γ. Other cytokines such as IL-1α and β, and TNF-α induce a smaller increase in MHC class II antigens on RIN cells, and appear to activate both the G-protein and the PKC signal transduction pathways to varying degrees. Therefore, injury of pancreatic β-cells and possible induction of autoimmune type 1 diabetes via various cytokines may be caused by IL-6 or IFN-γ, or by their ability to induce MHC class II antigen upregulation

Application of a primal-dual interior point algorithm using exact second order information with a novel non-monotone line search method to generally constrained minimax optimization problems

This work presents the application of a primal-dual interior point method to minimax optimisation problems. The algorithm differs significantly from previous approaches as it involves a novel non-monotone line search procedure, which is based on the use of standard penalty methods as the merit function used for line search. The crucial novel concept is the discretisation of the penalty parameter used over a finite range of orders of magnitude and the provision of a memory list for each such order. An implementation within a logarithmic barrier algorithm for bounds handling is presented with capabilities for large scale application. Case studies presented demonstrate the capabilities of the proposed methodology, which relies on the reformulation of minimax models into standard nonlinear optimisation models. Some previously reported case studies from the open literature have been solved, and with significantly better optimal solutions identified. We believe that the nature of the non-monotone line search scheme allows the search procedure to escape from local minima, hence the encouraging results obtained

Endometriosis and Infertility: A Multi-cytokine Imbalance Versus Ovulation, Fertilization and Early Embryo Development

Endometriosis is tightly linked to infertility which is manifested at very early or more advanced stages of the gestational cycle. Alteration on the production of a great number of cytokines/growth factors can be accused for problems on ovum maturation, fertilization or implantation. Yet, macroscopically these stages are characterized by the inability of conception. A closer look of the cytokinic profile during the conceptional and early gestational cycle could, however, localize the problem and allow a therapeutic approach. In this commentary, going through the cytokine requirement during ovulation, fertilization and the early stages of pregnancy, it became possible to specifically define the harmful endometriosis-induced cytokines for each of the conceptional and early gestational stages. Thus, regulating the levels of interferon-γ and tumor necrosis-α will facilitate ovulation and fertilization, whereas adjusting the levels of interleukin-1β and colony stimulating gactor-1 will facilitate implantation