Features of Polymeric Structures By Surface—Selective Laser Sintering of Polymer Particles Using Water as Sensitizer

The development of scaffolds with strictly specific properties is a key aspect of functional tissue regeneration, and it still remains one of the greatest challenges for tissue engineering. This study is aimed to determine the possibility of producing three-dimensional polylactide (PLA) scaffolds using the method of surface-selectiv  laser sintering (SSLS) for bone tissue regeneration. In this work, the authors also improved PLA scaffold adhesion properties, which are crucial for successful cellular growth and expansion. Thus, SSLS method proved to be effective in designing threedimensional porous scaffolds with differentiated mechanical properties. Keywords: regenerative medicine, scaffolds, polylactide, surface – selective laser . sintering, tissue engeneering

A CLINICAL CASE OF NORVEGIAN SCABIES IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKAEMIA

A case of Norwegian scabies is described in a patient of 19 years with a lesion of the scalp, face, trunk, upper and lower extremities that occurred against the background of acute lymphoblastic leukemia. A good effect was obtained from conducting etiotropic, pathogenetic and symptomatic therapy in combination with specific treatment of the underlying disease

Broadband source of polarization entangled photons

A broadband source of polarization entangled photons based on type-II spontaneous parametric down conversion from a chirped PPKTP crystal is presented. With numerical simulation and experimental evaluation, we report a source of broadband polarization entangled states with a bandwidth of approximately 125 nm for use in quantum interferometry. The technique has the potential to become a basis for the development of flexible broadband sources with designed spectral properties. © 2012 Optical Society of America OCIS codes: 270.4180, 230.4320. A challenge in high resolution quantum interferometry is the production of high quality broadband polarization entangled states. In the past, broad spectra have been produced with thin crystals since the bandwidth of the spontaneous parametric down conversion (SPDC) spectrum is inversely proportional to the length of the crystal By considering the crystal as a superposition of distributed sources along the propagation direction whose lengths vary linearly as illustrated in the inset of z j − z 0 with j ∈ 1; N, where N is the number of distributed sources, p 0 is the degenerate phase matching period given by p 0 2λ p ∕2n p λ p − n s 2λ p − n i 2λ p , Δp is a chirping parameter, z j is the location of the jth source, and z 0 is the location of p 0 along the propagation axis. For example, a chirped crystal with 20% chirping and p 0 located in the center of the crystal has parameters Δp 0.2 and z 0 L c ∕2, where L c is the total length of the crystal. Assuming a plane wave pump and considering only the collinear signal and idler modes, the joint spectrum of SPDC photons is proportional to the Fourier transform of the longitudinally varying second order nonlinear coefficient. Following the procedure from where The spectrum results from a superposition of single crystal spectra, which is evident from the sum of sinc functions. Because of a position dependent spectral phase, the output spectrum will have "bumpy" features due to interference from spectral components born at different locations in the crystal. The measured tuning curves displaying the spatial and spectral structure of a chirped PPKTP crystal with Δp 0.2 and z 0 L c ∕2 are shown i

2030) Dispersion; (120.3180) Interferometry; (270.0270) Quantum Optics

Abstract: The use of quantum correlations between photons to measure polarization mode dispersion (PMD) and chromatic dispersion is investigated. Two types of apparatus are discussed which use coincidence counting of entangled photon pairs to allow sub-femtosecond resolution for measurement of both PMD and chromatic dispersion, as well as separation of even-order and odd-order chromatic effects in the PMD. Group delays can be measured with a resolution of order 0.1 fs, whereas attosecond resolution can be achieved for phase delays

EVALUATION OF FCR THERAPY EFFICACY IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA BASED ON IMMUNOGENETIC CRITERIA

A number of studies have shown that distinct common variants of the genes controlling immune/inflammatory response may affect efficiency of chronic lymphocytic leukemia (CLL) treatment. In a recently published paper, we reported polymorphic variants of some immune response genes in CLL patients to be associated with different rates of disease progression. Correlations between the distribution of gene modification profiles in indolent and agressive forms of CLL have been established. The present study describes results of pharmacogenetic studies aimed for identifying associations between the immune response genes polymorphism, and efficacy of FCR treatment regimen in CLL patients. 19 polymorphic loci of 14 immune response genes were studied in 33 patients with CLL who received FCR therapy. The TLR2, TLR3, TLR4, TLR6, TLR9, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17A, CD14, TNFα, FCGR2A genotypes were determined by polymerase chain reaction with allele-specific primers. CLL patients were divided into several groups depending on the terms of response to FCR treatment, i.e., achieving partial/complete remission after two, four, six courses of treatment, and those who did not respond to the therapy. Statistically significant differences in the distribution of haplotype frequencies were detected for the following genes: IL-1β (C-3953T, p = 0.02-0.009); IL-10 (C-819T, p = 0.04); IL-10 (G-1082A, p = 0.04-0.002-0.006), FCGR2A (His166Arg, p = 0.006); TLR4 (Thr399Ile, p = 0.02); TLR6 (Ser249Pro, p = 0.04); TLR9 (A2848G, p = 0.04-0.007); CD14 (C-159T, p = 0.03). When testing the significance hypothesis by multiple comparisons, the difference for the detected events was confirmed only for IL-10 gene (G-1082A, p < 0.01; χ2 = 20,082). The results show a relationship between the allelic status of the IL-10-1082 gene and the timing of response to FCR therapy, as well as predict a group of patients with primary-resistant CLL before treatment. The role of the relationship between IL-10 gene polymorphism and IL-10 production is discussed in connection with occurrence risk and clinical course of mature B-cell lymphoid malignancies. IL-10 is thought to be a growth factor for normal and transformed human B-lymphocytes, it controls a balance between cellular and humoral immune responses while exerting a pronounced immunosuppressive activity, along with ability to stimulate tumor cell proliferation. A rationale for conducting pharmacogenomic studies in CLL is provided, in order to predict efficiency of a specific drug or their combination in a distinct patient, thus representing chances to detect a factor which may influence success of the therapy since its earlier stage

Bone remodeling in women with diabetes mellitus

Background. 1t is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at different age periods. Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods. Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C-terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched. Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM. Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved menstrual function

Neurological «masks» of multiple myeloma. Literature review and clinical case

The article provides an overview of recent scientific publications on the problem of damage to the nervous system in multiple myeloma. In half of the patients, myeloma is debuted with persistent pain syndrome associated with destructive lesion of the flat bones and compression of the roots and spinal cord. In 20% of cases, polyneuropathy develops as a manifestation of the underlying disease, as well as a complication of chemotherapy used to treat myeloma. Involvement of the nervous system is always secondary, but usually develops before the clinic of the main hematological disease or symptoms of damage to the nervous system muffle the clinic of multiple myeloma. There is a need for diagnostic alertness of specialists regarding oncohematological pathology. After chemotherapy, most patients need advice from neurologists in connection with polyneuropathy developing on this background. Over the past decades, the mechanisms of damage and the pathogenesis of polyneuropathy on the background of tumor blood diseases, which are presented in the article, have been described. The same is a clinical case of myeloma, anifested by neurological symptoms.В статье приведен обзор научных публикаций последних лет, посвященных проблеме поражения нервной системы при множественной миеломе. У половины пациентов миеломная болезнь дебютирует стойким болевым синдромом, связанным с деструктивным поражением плоских костей и компрессией корешков и спинного мозга. В 20% случаев развивается полинейропатия как проявление основного заболевания и как осложнение химиотерапии, применяемой для лечения миеломной болезни. Вовлечение нервной системы всегда вторично, но развивается, как правило, раньше клиники основного гематологического заболевания, или симптомы поражения нервной системы заглушают клинику множественной миеломы. Необходима диагностическая настороженность специалистов в отношении онкогематологической патологии. Большинство пациентов после проведенной химиотерапии нуждаются в консультативной помощи неврологов в связи с развивающимися на этом фоне полинейропатиями. За последние десятилетия были описаны механизмы поражения и патогенез полинейропатии на фоне опухолевых заболеваний крови, которые и представлены в статье. так же приведен клинический случай течения миеломной болезни, манифестировавшийся неврологической симптоматикой