Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study

Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven patients who were listed between 2005 and 2015 for decompensation, but later delisted following recompensation were included. Alcohol-related liver disease (ALD) was the underlying etiology in the majority (n=47, 61%). Listing characteristics of these patients were compared with those of decompensated ALD patients who either underwent deceased donor liver transplantation or died on the waiting list. The model for end-stage liver disease (MELD) score <20 and serum albumin ≥32g/l at listing were the only independent predictors of recompensation/delisting in ALD. The probability of recompensation was 70% when both factors were present at listing. Interestingly, about a tenth of decompensated ALD patients who died on the waiting list (median duration on waiting list 11 months) and a quarter of decompensated ALD patients who underwent living donor liver transplantation (median duration on waiting list 2 months) also had both factors at listing. In conclusion, ALD seems to be the most favorable etiology for recompensation beyond the need for transplantation. Both MELD and serum albumin at listing independently predict recompensation/delisting in ALD. It seems advisable to implement a period of observation for ALD patients with both favorable factors, before embarking on living donor liver transplantation

Conjoint PERSONA – SOPRANO Workshop 1

Abstract. Being both EU-IST integrated projects in the field of AAL, PERSONA and SOPRANO organized a conjoint workshop on the occasion of the AmI-07 conference in order for the researchers of the projects to exchange insights of the approaches to the key field challenges, the achievements so far in each of the projects, and possible synergies in the future. Here, we summarize the exchanged info and the workshop results. The paper gives a good overview of the two projects and their status by the end of October 2007. Keywords: EU-IST integrated project, ambient intelligence, assisted living, use cases and scenarios, architectural design, technological approach

Dynamic Programming for HH-minor-free Graphs

International audienceWe provide a framework for the design and analysis of dynamic programming algorithms for H-minor-free graphs with branchwidth at most k. Our technique applies to a wide family of problems where standard (deterministic) dynamic programming runs in 2 O(k*logk)*n O(1) steps, with n being the number of vertices of the input graph. Extending the approach developed by the same authors for graphs embedded in surfaces, we introduce a new type of branch decomposition for H-minor-free graphs, called an H-minor-free cut decomposition, and we show that they can be constructed in O h (n 3) steps, where the hidden constant depends exclusively on H. We show that the separators of such decompositions have connected packings whose behavior can be described in terms of a combinatorial object called ℓ-triangulation. Our main result is that when applied on H-minor-free cut decompositions, dynamic programming runs in 2Oh(k)⋅nO(1) steps. This broadens substantially the class of problems that can be solved deterministically in single-exponential time for H-minor-free graphs

ACTIVAGE - Interoperability layer architecture

This document is the deliverable D3.2.2 or D3.7 &quot;ACTIVAGE Interoperability layer architecture&quot; and represent the main outcome of the activity T3.1 &quot;Specification of the open cross-pilot ACTIVAGE architecture&quot;, that is part of Work Package WP3 &quot;ACTIVATE Secure Interoperability Layer&quot;. The present document is also tightly related to other WP3 task: T3.4 &quot;Implementation of the interoperability layer&quot; that integrates T3.2 &quot;ACTIVAGE solution for security and privacy&quot; and T3.3 &quot;Building bridges to the IoT protocols and platforms&quot;. The overall scope of this deliverable is to present the ACTIVATE Interoperability layer architecture. The content of this deliverable can be summarized as follows: Section 1 describes the nature and the reason why this deliverable 3.2.2 has particular relevance for the ACTIVAGE project. Moreover, this section also set the objectives to the defined structure and organisation of the document, and notes the differences between the 2 versions of the deliverable (D3.2 and D3.2.2). Section 2 is an introductory section that provides a brief description about main concepts from the Internet of Things that are involved in the ACTIVAGE project. This section also addresses the potential of Internet of Things in the context of the Active and Healthy Ageing area that concerns the ACTIVAGE project. In this section, the objectives and proposals of the deliverable are explained in detail besides the challenges that must be confronted to reach the deliverable goals. Section 3 of the present document is dedicated to the IoT Platform Interoperability State of the Art. This section is fruit of an extensive research and organisational collective work, as it is described in the section below. Here the main objectives to pursue, such as the achievement of interoperability within IoT platforms, are explained. The definitions, terminology and main concepts of IoT platforms are detailed in a clear descriptive way and along with a summary of the main features of each IoT platform that is involved in the project this section represent a pivotal part for the semantic interoperability specification in the full project. Interoperability use cases of the Activage IoT Ecosystem Suite (AIoTES) are described. The last point of this section includes the architecture of the Deployment Sites. Section 4 in this deliverable addresses the Semantic Interoperability concept, and the AIoTES common data model is introduced. Section 5 presents the ACTIVAGE Architecture, on where the IoT Semantic Interoperability Layer is included as a core part of it, and its functionality and internal elements are detailed. All main components of the architecture are described in this section, as architectural building blocks. Also, the interfacing among different blocks is explained. The main objective of this part of the deliverable is shared whose first aiming to efficiently and effectively integrate the platforms and devices of the IoT-AHA Ecosystem and second to provide the guidance for deployment sites on procedures for such integration. Finally, the document ends with the conclusions and the future work