Danish values, the foundation of the Folkeskole

We have imaged with Hubble Space Telescope WFC3/UVIS the central 2′7 × 2′7 region of the giant elliptical galaxy M87, using the ultraviolet filter F275W. In combination with archival ACS/WFC data taken through the F606W and F814W filters, covering the same field, we have constructed integrated-light UV-optical colors and magnitudes for 1460 objects, most of which are believed to be globular clusters (GCs) belonging to M87. The purpose was to ascertain whether the multiple-populations syndrome, ubiquitous among Galactic GCs, also exists among the M87 family of clusters. To achieve this goal, we sought those GCs with exceptionally blue UV-to-optical colors because helium-enriched sub-populations produce a horizontal-branch morphology that is well populated at high effective temperature. For comparison, integrated, synthetic UV-optical and purely optical colors and magnitudes have been constructed for 45 Galactic GCs, starting from individual-star photometry obtained with the same instruments and the same filters. We identify a small group of M87 clusters exhibiting a radial UV-optical color gradient, representing our best candidate GCs hosting multiple populations with extreme helium content. We also find that the central spatial distribution of the bluer GCs is flattened in a direction parallel to the jet, while the distribution of redder GCs is more spherical. We release to the astronomical community our photometric catalog in F275W, F606W, and F814W bands and the high-quality image stacks in the same bands

Impact of different definitions of clear-sky flux on the determination of longwave cloud radiative forcing: NICAM simulation results

Using one month of the cloud-resolving Nonhydrostatic Icosahedral Atmospheric Model (NICAM) simulations, we examined the impact of different definitions of clear-sky flux on the determination of longwave cloud radiative forcing (CRF). Because the satellite-like cloud-free composite preferentially samples drier conditions relative to the all-sky mean state, the conventional clear-sky flux calculation using the all-sky mean state in the model may represent a more humid atmospheric state in comparison to the cloud-free state. The drier bias is evident for the cloud-free composite in the NICAM simulations, causing an overestimation of the longwave CRF by about 10% compared to the NICAM simulated longwave CRF. Overall, water vapor contributions of up to 10% of the total longwave CRF should be taken account for making model-generated cloud forcing comparable to the satellite measurements

Hot Populations in M87 Globular Clusters

We have obtained HST/STIS far- and near-UV photometry of globular clusters in four fields in the gE galaxy M87. To a limit of m(FUV) = 25 we detect a total of 66 globular clusters (GCs) in common with the deep HST optical-band study of Kundu et al. (1999). Despite strong overlap in V- and I-band properties, the M87 GCs have UV/optical properties that are distinct from clusters in the Milky Way and in M31. M87 clusters, especially metal-poor ones, produce larger hot HB populations than do Milky Way analogues. Cluster mass is probably not a factor in these distinctions. The most metal-rich M87 GCs in our sample are near Z_sun and overlap the local E galaxy sample in estimated Mg_2 line indices. Nonetheless, the clusters produce much more UV light at a given Mg_2, being up to 1 mag bluer than any gE galaxy in (FUV-V) color. The M87 GCs do not appear to represent a transition between Milky Way-type clusters and E galaxies. The differences are in the correct sense if the clusters are significantly older than the E galaxies. Comparisons with Galactic open clusters indicate that the hot stars lie on the extreme horizontal branch, rather than being blue stragglers, and that the EHB becomes well populated for ages > 5 Gyr. We find that 43 of our UV detections have no optical-band counterparts. Most appear to be UV-bright background galaxies, seen through M87. Eleven NUV variable sources detected at only one epoch in the central field are probably classical novae. [Abridged]Comment: 70 pages, 25 figures (including 4 jpgs), 7 tables. To appear in AJ. Full resolution version available at http://www.astro.virginia.edu/~rwo/m87/m87-hotpops.pd

MicroRNA-24 regulates vascularity after myocardial infarction

BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS: Here, we show that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays. Respective downstream signaling cascades involving phosphorylated BAD (Bcl-XL/Bcl-2-associated death promoter) and Sirtuin1 were identified by transcriptome, protein arrays, and chromatin immunoprecipitation analyses. Overexpression of miR-24 or silencing of its targets significantly impaired angiogenesis in zebrafish embryos. Blocking of endothelial miR-24 limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. CONCLUSIONS: Our findings indicate that miR-24 acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease. [KEYWORDS: Animals, Apoptosis/drug effects, Arterioles/pathology, Capillaries/pathology, Cell Hypoxia, Cells, Cultured/drug effects/metabolism, Collagen, Drug Combinations, Drug Evaluation, Preclinical, Endothelial Cells/ metabolism/pathology, GATA2 Transcription Factor/biosynthesis/genetics, Gene Expression Profiling, Heart Failure/etiology, Heme Oxygenase-1/biosynthesis/genetics, Laminin, Male, Mice, Mice, Inbred C57BL, MicroRNAs/antagonists & inhibitors/genetics/ physiology, Myocardial Infarc

Quantum effects in a superconducting glass model

We study disordered Josephson junctions arrays with long-range interaction and charging effects. The model consists of two orthogonal sets of positionally disordered $N$ parallel filaments (or wires) Josephson coupled at each crossing and in the presence of a homogeneous and transverse magnetic field. The large charging energy (resulting from small self-capacitance of the ultrathin wires) introduces important quantum fluctuations of the superconducting phase within each filament. Positional disorder and magnetic field frustration induce spin-glass like ground state, characterized by not having long-range order of the phases. The stability of this phase is destroyed for sufficiently large charging energy. We have evaluated the temperature vs charging energy phase diagram by extending the methods developed in the theory of infinite-range spin glasses, in the limit of large magnetic field. The phase diagram in the different temperature regimes is evaluated by using variety of methods, to wit: semiclassical WKB and variational methods, Rayleigh-Schr\"{o}dinger perturbation theory and pseudospin effective Hamiltonians. Possible experimental consequences of these results are briefly discussed.Comment: 17 pages REVTEX. Two Postscript figures can be obtained from the authors. To appear in PR

Novel 1.5 GPa-strength with 50%-ductility by transformation-induced plasticity of non-recrystallized austenite in duplex steels

Needs for steel designs of ultra-high strength and excellent ductility have been an important issue in worldwide automotive industries to achieve energy conservation, improvement of safety, and crashworthiness qualities. Because of various drawbacks in existing 1.5-GPa-grade steels, new development of formable cold-rolled ultra-high-strength steels is essentially needed. Here we show a plausible method to achieve ultra-high strengths of 1.0~1.5 GPa together with excellent ductility above 50% by actively utilizing non-recrystallization region and TRansformation-Induced Plasticity (TRIP) mechanism in a cold-rolled and annealed Fe-Mn-Al-C-based steel. We adopt a duplex microstructure composed of austenite and ultra-fine ferrite in order to overcome low-yield-strength characteristics of austenite. Persistent elongation up to 50% as well as ultra-high yield strength over 1.4 GPa are attributed to well-balanced mechanical stability of non-crystallized austenite with critical strain for TRIP. Our results demonstrate how the non-recrystallized austenite can be a metamorphosis in 1.5-GPa-grade steel sheet design. ? 2017 The Author(s).114Ysciescopu

The F-GAMMA program: Multi-frequency study of Active Galactic Nuclei in the Fermi era. Program description and the first 2.5 years of monitoring

To fully exploit the scientific potential of the Fermi mission, we initiated the F-GAMMA program. Between 2007 and 2015 it was the prime provider of complementary multi-frequency monitoring in the radio regime. We quantify the radio variability of gamma-ray blazars. We investigate its dependence on source class and examine whether the radio variability is related to the gamma-ray loudness. Finally, we assess the validity of a putative correlation between the two bands. The F-GAMMA monitored monthly a sample of about 60 sources at up to twelve radio frequencies between 2.64 and 228.39 GHz. We perform a time series analysis on the first 2.5-year dataset to obtain variability parameters. A maximum likelihood analysis is used to assess the significance of a correlation between radio and gamma-ray fluxes. We present light curves and spectra (coherent within ten days) obtained with the Effelsberg 100-m and IRAM 30-m telescopes. All sources are variable across all frequency bands with amplitudes increasing with frequency up to rest frame frequencies of around 60 - 80 GHz as expected by shock-in-jet models. Compared to FSRQs, BL Lacs show systematically lower variability amplitudes, brightness temperatures and Doppler factors at lower frequencies, while the difference vanishes towards higher ones. The time scales appear similar for the two classes. The distribution of spectral indices appears flatter or more inverted at higher frequencies for BL Lacs. Evolving synchrotron self-absorbed components can naturally account for the observed spectral variability. We find that the Fermi-detected sources show larger variability amplitudes as well as brightness temperatures and Doppler factors, than non-detected ones. Flux densities at 86.2 and 142.3 GHz correlate with 1 GeV fluxes at a significance level better than 3sigma, implying that gamma rays are produced very close to the mm-band emission region.Comment: Accepted for publication in section 4. Extragalactic astronomy of Astronomy and Astrophysics (18 pages, 9 figures