The added mass coefficient of a dispersion of spherical gas bubbles in liquid

Models published in the two-phase flow literature for the added mass coefficient of a dilute bubbly dispersion are discussed and compared. It is shown that the differences between the models are mainly due to the different ways in which the added mass is defined. Also, approximate expressions for the added mass coefficient of non-dilute bubbly dispersions are given. Finally, the use of the models in an equation for the average motion of the bubbles is briefly discussed

Phase and period responses of the circadian system of mice (Mus musculus) to light stimuli of different duration

To understand entrainment of circadian systems to different photoperiods in nature, it is important to know the effects of single light pulses of different durations on the free-running system. The authors studied the phase and period responses of laboratory mice (C57BL6J//OlaHsd) to single light pulses of 7 different durations (1, 3, 4, 6, 9, 12, and 18 h) given once per 11 days in otherwise constant darkness. Light-pulse duration affected both amplitude and shape of the phase response curve. Nine-hour light pulses yielded the maximal amplitude PRC. As in other systems, the circadian period slightly lengthened following delays and shortened following advances. The authors aimed to understand how different parts of the light signal contribute to the eventual phase shift. When PRCs were plotted using the onset, midpoint, and end of the pulse as a phase reference, they corresponded best with each other when using the mid-pulse. Using a simple phase-only model, the authors explored the possibility that light affects oscillator velocity strongly in the 1st hour and at reduced strength in later hours of the pulse due to photoreceptor adaptation. They fitted models based on the 1-h PRC to the data for all light pulses. The best overall correspondence between PRCs was obtained when the effect of light during all hours after the first was reduced by a factor of 0.22 relative to the 1st hour. For the predicted PRCs, the light action centered on average at 38% of the light pulse. This is close to the reference phase yielding best correspondence at 36% of the pulses. The result is thus compatible with an initial major contribution of the onset of the light pulse followed by a reduced effect of light responsible for the differences between PRCs for different duration pulses. The authors suggest that the mid-pulse is a better phase reference than lights-on to plot and compare PRCs of different light-pulse durations

Work, play and boredom

This special issue focuses on the interconnections between work, play and boredom in contemporary organizations and features contributions by Donncha Kavanagh, Joyce Goggin, Abe Walker, Norman Jackson and Pippa Carter, Niels �kerstr�m Andersen, Hanne Knudsen, Ole Bjerg, Sophie-Th�r�se Krempl and Timon Beyes, Rasmus Johnsen, Jacob J. Peters, and Peter Fleming. The contributions seek to shed light on the way in which play is becoming increasingly incorporated within the world of work and open on to the question of how we might problematize this phenomenon. Boredom emerges as a prominent theme that provides a critical - if ambiguous - counterpoint to the management of fun and frivolity within modern-day corporations. Encompassing both sociological and philosophical reflections, the papers in this special issue add to ongoing debates around the politics of play currently taking place in the field of organization studies. This issue emerged from the ephemera conference on the same theme held at the University of St Andrews in May 2010

A Trial Examining an Advanced Practice Nurse Intervention to Promote Medication Adherence and Symptom Management in Adult Cancer Patients Prescribed Oral Anti-Cancer Agents: Study Protocol

Aim: To report a study protocol that refines then examines feasibility, preliminary efficacy, and satisfaction of ADHERE, an intervention using motivational interviewing and brief cognitive behavioral therapy as a mechanism for goal-oriented systematic patient education to promote symptom management and adherence among cancer patients prescribed oral anti-cancer agents. Background: Cancer treatment with oral anti-cancer agents shifts responsibility for managing treatment from clinicians in supervised cancer centers to patients and their caregivers. Thus, a need exists to standardize start-of-care for support patient self-management of care at home. Design: A two-phase quasi-experimental sequential design with repeated measures. Methods: Sixty five adult patients newly prescribed an oral anti-cancer agent will be recruited from three community cancer centers. Phase one will enroll 5 patients to refine the ADHERE intervention prior to testing, using an iterative process. After completion, Phase two will enroll 30 patients who receive usual care to examine symptoms and ahderence. Advanced practice nurses will then be trained. Then 30 patients will be enrolled in the intervention group and provided ADHERE, a 4-week intervention using semi-structured interactions (initial face-to-face session and once a week phone sessions over 3-weeks) and a Toolkit to promote self-management of care. Outcome measures include: oral anti-cancer agents adherence rate, symptom presence and severity, feasibility, and satisfaction with ADHERE. This protocol was approved January 2014 and is registered at ClinicalTrials.gov (Identifier NCT02337296). Discussion: This nurse-led intervention has the potential to standardize the start-of-care training for the patients to self-manage when prescribed oral anti-cancer agents for treatment

Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers

We focus on unique roles of miR-200c in breast, ovarian, and endometrial cancers. Members of the miR-200 family target ZEB1, a transcription factor which represses E-cadherin and other genes involved in polarity. We demonstrate that the double negative feedback loop between miR-200c and ZEB1 is functional in some, but not all cell lines. Restoration of miR-200c to aggressive cancer cells causes a decrease in migration and invasion. These effects are independent of E-cadherin status. Additionally, we observe that restoration of miR-200c to ovarian cancer cells causes a decrease in adhesion to laminin. We have previously reported that reintroduction of miR-200c to aggressive cells that lack miR-200c expression restores sensitivity to paclitaxel. We now prove that this ability is a result of direct targeting of class III beta-tubulin (TUBB3). Introduction of a TUBB3 expression construct lacking the miR-200c target site into cells transfected with miR-200c mimic results in no change in sensitivity to paclitaxel. Lastly, we observe a decrease in proliferation in cells transfected with miR-200c mimic, and cells where ZEB1 is knocked down stably, demonstrating that the ability of miR-200c to enhance sensitivity to paclitaxel is not due to an increased proliferation rate

On the Exchange of Kinetic and Magnetic Energy Between Clouds and the Interstellar Medium

We investigate, through 2D MHD numerical simulations, the interaction of a uniform magnetic field oblique to a moving interstellar cloud. In particular we explore the transformation of cloud kinetic energy into magnetic energy as a result of field line stretching. Some previous simulations have emphasized the possible dynamical importance of a ``magnetic shield'' formed around clouds when the magnetic field is perpendicular to the cloud motion (Jones et al. 1996, Miniati et al. 1998). It was not clear, however, how dependent those findings were to the assumed field configuration and cloud properties. To expand our understanding of this effect, we examine several new cases by varing the magnetic field orientation angle with respect to the cloud motion (\theta), the cloud-background density contrast, and the cloud Mach number. We show that in 2D and with \theta large enough, the magnetic field tension can become dominant in the dynamics of the motion of high density contrast, low Mach number clouds. In such cases a significant fraction of cloud kinetic energy can be transformed into magnetic energy with the magnetic pressure at the cloud nose exceeding the ram pressure of the impinging flow. We derive a characteristic timescale for this process of energy ``conversion''. We find also that unless the cloud motion is highly aligned to the magnetic field, reconnection through tearing mode instabilities in the cloud wake limit the formation of a strong flux rope feature following the cloud. Finally we attempt to interpret some observational properties of the magnetic field in view of our results.Comment: 24 pages in aaspp4 Latex and 7 figures. Accepted for publication in The Astrophysical Journa

GMRT Observations of the 2006 outburst of the Nova RS Ophiuchi: First detection of emission at radio frequencies < 1.4 GHz

The first low radio frequency (<1.4 GHz) detection of the outburst of the recurrent nova RS Ophiuchi is presented in this letter. Radio emission was detected at 0.61 GHz on day 20 with a flux density of ~48 mJy and at 0.325 GHz on day 38 with a flux density of ~ 44 mJy. This is in contrast with the 1985 outburst when it was not detected at 0.327 GHz even on day 66. The emission at low radio frequencies is clearly non-thermal and is well-explained by a synchrotron spectrum of index alpha ~ -0.8 (S propto nu^alpha) suffering foreground absorption due to the pre-existing, ionized, warm, clumpy red giant wind. The absence of low frequency radio emission in 1985 and the earlier turn-on of the radio flux in the current outburst are interpreted as being due to higher foreground absorption in 1985 compared to that in 2006, suggesting that the overlying wind densities in 2006 are only ~30% of those in 1985.Comment: 14 pages, 1 figure. Accepted for publication in ApJ

Familiekudde State of the Art

De Familiekudde is gebaseerd op de behoeften van de koe. Het biedt een natuurlijke leefomgeving voor rundvee door te werken met stabiele kuddes, het kalf bij de koe te laten en niet te onthoornen. In Familiekudde State of the Art schatten we op basis van wetenschappelijke kennis in wat de consequenties van het houden van een Familiekudde in de praktijk zijn en hoe er met verwachtte knelpunten omgegaan kan worden

Probing the Magnetized Interstellar Medium Surrounding the Planetary Nebula Sh 2-216

We present 1420 MHz polarization images of a 2.5 X 2.5 degree region around the planetary nebula (PN) Sh 2-216. The images are taken from the Canadian Galactic Plane Survey (CGPS). An arc of low polarized intensity appears prominently in the north-east portion of the visible disk of Sh 2-216, coincident with the optically identified interaction region between the PN and the interstellar medium (ISM). The arc contains structural variations down to the ~1 arcminute resolution limit in both polarized intensity and polarization angle. Several polarization-angle "knots" appear along the arc. By comparison of the polarization angles at the centers of the knots and the mean polarization angle outside Sh 2-216, we estimate the rotation measure (RM) through the knots to be -43 +/- 10 rad/m^2. Using this estimate for the RM and an estimate of the electron density in the shell of Sh 2-216, we derive a line-of-sight magnetic field in the interaction region of 5.0 +/- 2.0 microG. We believe it more likely the observed magnetic field is interstellar than stellar, though we cannot completely dismiss the latter possibility. We interpret our observations via a simple model which describes the ISM magnetic field around Sh 2-216, and comment on the potential use of old PNe as probes of the magnetized ISM.Comment: 25 pages, 4 figures. Accepted for publication in the Astrophysical Journa