Emerging Technologies for the Pretreatment of Lignocellulosic Biomass

Pretreatment of lignocellulosic biomass to overcome its intrinsic recalcitrant nature prior to the production of valuable chemicals has been studied for nearly 200 years. Research has targeted eco-friendly, economical and time-effective solutions, together with a simplified large-scale operational approach. Commonly used pretreatment methods, such as chemical, physico-chemical and biological techniques are still insufficient to meet optimal industrial production requirements in a sustainable way. Recently, advances in applied chemistry approaches conducted under extreme and non-classical conditions has led to possible commercial solutions in the marketplace (e.g. High hydrostatic pressure, High pressure homogenizer, Microwave, Ultrasound technologies). These new industrial technologies are promising candidates as sustainable green pretreatment solutions for lignocellulosic biomass utilization in a large scale biorefinery. This article reviews the application of selected emerging technologies such as ionizing and non-ionizing radiation, pulsed electrical field, ultrasound and high pressure as promising technologies in the valorization of lignocellulosic biomass

High performance 3D sound localization for surveillance applications

One of the key features of the human auditory system, is its nearly constant omni-directional sensitivity, e.g., the system reacts to alerting signals coming from a direction away from the sight of focused visual attention. In many surveillance situations where visual attention completely fails since the robot cameras have no direct line of sight with the sound sources, the ability to estimate the direction of the sources of danger relying on sound becomes extremely important. We present in this paper a novel method for sound localization in azimuth and elevation based on a humanoid head. The method was tested in simulations as well as in a real reverberant environment. Compared to state-of-the-art localization techniques the method is able to localize with high accuracy 3D sound sources even in the presence of reflections and high distortion

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this review is to elaborate the mechanical and physical properties that affect its stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements. This review also summarizes variations in these properties during PLA processing (i.e. thermal degradation and recyclability), biodegradation, packaging and sterilization, and aging (i.e. weathering and hygrothermal). In addition, we discuss up-to-date strategies for PLA properties improvements including components and plasticizer blending, nucleation agent addition, and PLA modifications and nanoformulations. Incorporating better understanding of the role of these properties with available improvement strategies is the key for successful utilization of PLA and its copolymers/composites/blends to maximize their fit with worldwide application needs. Keywords: Physical and mechanical properties; PLA; Biodegradable polymers; Polymer processing; Application

Lignocellulosic Biorefineries in Europe: Current State and Prospects

Lignocellulosic biorefining processes plant-derived biomass into a range of bio-based products. Currently, more than 40 lignocellulosic biorefineries are operating across Europe. Here, we address the challenges and future opportunities of this nascent industry by elucidating key elements of the biorefining sector, including feedstock sourcing, processing methods, and the bioproducts market

Identifying the common interaction networks of amoeboid motility and cancer cell metastasis

The recently analyzed genome of Naegleria gruberi, a free-living amoeboflagellate of the Heterolobosea clade, revealed a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal-, motility- and signaling-genes. This protist, which diverged from other eukaryotic lineages over a billion years ago, possesses the ability for both amoeboid and flagellar motility. In a phylogenomic comparison of two free living eukaryotes with large proteomic datasets of three metastatic tumour entities (malignant melanoma, breast- and prostate-carcinoma), we find common proteins with potential importance for cell motility and cancer cell metastasis. To identify the underlying signaling modules, we constructed for each tumour type a protein-protein interaction network including these common proteins. The connectivity within this interactome revealed specific interactions and pathways which constitute prospective points of intervention for novel anti-metastatic tumour therapies

Fibulin-2 is required for basement membrane integrity of mammary epithelium

Fibulin-2 (FBLN2) is a secreted extracellular matrix glycoprotein which has been associated with tissue development and remodelling. In the mouse mammary gland, FBLN2 can be detected during ductal morphogenesis in cap cells and myoepithelial cells at puberty and early pregnancy, respectively. In an attempt to assign its function, we knocked down Fbln2 in the mouse mammary epithelial cell line EpH4. FBLN2 reduction led to an increase in the size of spheroidal structures when compared to scrambled control shRNA-transduced cells plated on Matrigel matrix. This phenotype was associated with a disruption of the collagen IV sheath around the epithelial spheroids and downregulation of integrin β1, suggesting a role for FBLN2 in stabilizing the basement membrane (BM). In contrast to mice, in normal adult human breast tissue, FBLN2 was detected in ductal stroma, and in the interlobular stroma, but was not detectable within the lobular regions. In tissue sections of 65 breast cancers FBLN2 staining was lost around malignant cells with retained staining in the neighbouring histologically normal tissue margins. These results are consistent with a role of FBLN2 in mammary epithelial BM stability, and that its down-regulation in breast cancer is associated with loss of the BM and early invasion

Analisis Inovasi, Promosi, dan Kompetensi Marketer terhadap Keputusan Pembelian Produk Batik Arcobaleno di Surakarta

This study aims to examine the effect of innovation, promotion, and marketer competence on the decision to purchase arcobaleno batik products in Surakarta. The population in this study were 200 consumers of arcobaleno batik, while the sample used was 100 consumers of batik products in the company Arcobaleno using quantitative methods, namely data measured in the form of numbers. The results of this study indicate that, marketer competencies significantly have an influence on purchasing decisions of batik products in arcobaleno companies, while innovation and promotion variables have no influence on purchasing decisions. Based on the test of the coefficient of determination (R2) it is known that the adjusted R square value is 0.222 or equal to 22.2%. This means that 22.2% of purchasing decisions can be explained by independent variables of innovation, promotion, and marketer competence. While the remaining 77.8% is explained by other variables besides the explanatory or independent variables outside of this study. Keyword : innovation, promotion, marketer competence, purchase decisio

An Agent-Based Computational Bioeconomic Model of Plant Disease Diffusion and Control: Grapevine Leafroll Disease

WP 2013-11 February 2013JEL Classification Codes: C15; C63; D24; Q1