ТЕОРИЯ ПОКОЛЕНИЙ КАК ИНСТРУМЕНТ АНАЛИЗА, ФОРМИРОВАНИЯ И РАЗВИТИЯ ТРУДОВОГО ПОТЕНЦИАЛА

The modern Strauss–Howe generational theory created at the intersection of economic, sociological, historical and psychological Sciences. She focuses primarily on difference of attitudes of generations, due to the specific social environment, corresponding to a certain period of time. Such a perspective on issues related to the human factor in the economy, has recently attracted interest not only from researchers, but also finds application for solving practical problems in some fields of business.Subject / theme. The article is devoted to one of the urgent contemporary socio-economic problems – the issue of the formation and development of labor potential. In this context, the theory of generations is offered by the authors as a tool for the study of qualitative parameters of human resources and the planning of future work opportunities in our country. In particular, the article considers the main aspects of the classical version of the Strauss–Howe generational theory and its Russian adaptation. Statistics describing the General demographics and working population of Russia from the point of view of generational groups. On this basis, a forecast is made of the labor potential of the country in the long term structure, review and compare the basic values and business characteristics of its constituent generations. Problem areas for which use of generational approach is rational are revealed and the corresponding recommendations are made.Objectives. The purpose of this article is justification of the possible application of provisions of modern theories of generations to identify and predict the dynamics of qualitative characteristics of the domestic workforce, as well as the prospects of its use in order to control the formation and development of labor potential.Methods. Methodological basis of the presented work make comparative and economic-statistical and socio-cultural methods of analysis.Results. In the framework of this article, the authors determined that of the five generations living in Russia today four groups constitute the major workforce of the country. At the same time in terms of labour potential for the future advisable to consider three generations, the evaluation value characteristics which showed significant differences in their social and personal attitudes that affect attitudes to education, the acquisition of professional skills and work as a whole. This situation carries the negative points, so it is important to establish quality of intergenerational interaction and choose the right vector of development of labor potential, aimed at the successful development of the domestic economy.Conclusions /significance. Practical value of the study is that the authors offer recommendations for the use of the theory of generations as a management tool can be applied in the framework of the tasks of formation and development of labour potential at the level of countries and individual organizations.Современная теория поколений Хоува и Штрауса, созданная на стыке экономических, социологических, исторических и психологических наук, ориентируется в первую очередь на различие ценностных установок поколений, обусловленное спецификой общественной среды, соответствующей определенному периоду времени. Такой ракурс рассмотрения вопросов, связанных с человеческим фактором в экономике, в последнее время вызывает интерес не только со стороны исследователей, но и находит применение для решения практических задач в некоторых сферах бизнеса.Предмет / тема. Статья посвящена одной из актуальных современных социально-экономических проблем – вопросу формирования и развития трудового потенциала.  В данном контексте теория поколений предлагается авторами в качестве инструмента исследования качественных параметров трудовых ресурсов и планирования будущих трудовых возможностей нашей страны. В том числе, в статье рассматриваются основные аспекты классической версии теории поколений Хоува и Штрауса и ее отечественной адаптации. Приводятся статистические  данные, характеризующие общий демографический состав и трудоспособное население России с точки зрения поколенных групп. На этой основе сделан прогноз структуры трудового потенциала страны в перспективе, рассмотрены и сопоставлены  основные ценностные  и деловые характеристики  составляющих  его поколений. Выявлены проблемные области, для которых рационально использование поколенческого подхода и даны соответствующие рекомендации.Цель / задачи. Целью настоящей статьи является обоснование возможностей применения положений современной теории поколений для выявления и прогнозирования динамики качественных характеристик отечественных  трудовых ресурсов, а также перспективности ее использования в целях управления формированием и развитием трудового потенциала.Методология. Методическую основу представленной работы составляют сравнительный, экономико-статистический и социально-культурный методы анализа.Результаты. В рамках изложения данной статьи авторами  определено, что из пяти поколений, проживающих в России, на сегодняшний день четыре группы составляют  основные трудовые ресурсы страны. При этом в плане трудового потенциала на перспективу целесообразно рассматривать три поколения, оценка ценностных характеристик которых показала существенную разницу их социально-личностных установок, влияющих  на отношение  к образованию, приобретению  профессиональных навыков и труду в целом. Данная ситуация несет в себе негативные моменты, поэтому важно наладить качественное  межпоколенное взаимодействие  и выбрать правильный  вектор развития трудового потенциала,  нацеленный на успешное развитие отечественной экономики.Выводы /значимость.  Практическое значение исследования состоит в том, что предлагаемые авторами  рекомендации по использованию наработок теории поколений в качестве инструмента  управления могут быть применены в рамках задач формирования и развития трудового потенциала как на уровне страны, так и отдельной организации

УСТОЙЧИВОЕ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЕ РАЗВИТИЕ КАК ОСНОВА ГЕОПОЛИТИЧЕСКОЙ СТАБИЛЬНОСТИ НАЦИОНАЛЬНОЙ ЭКОНОМИКИ

In article basics of innovative transformation of national economy and society are covered, negative tendencies of transitive transition to the new social and economic relations, including being expressed in decrease in enterprise activity are defined. In article it is proved that transition from industrialization to innovative economy and information society is possible only on condition of preservation of a sustainable development due to effective and rational operation of the cognitive resources forming strategic potential of balanced social and economic growth.В статье рассматриваются основы инновационной трансформации национальной экономики и общества, определены негативные тенденции транзитивного перехода к новым социально-экономическим отношениям, в том числе выражающиеся в снижении предпринимательской активности. В статье обосновано, что переход от индустриализации к инновационной экономике и информационному обществу возможен только при условии сохранения устойчивого развития за счет эффективной и рациональной эксплуатации когнитивных ресурсов, формирующих стратегический потенциал сбалансированного социально-экономического роста

Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease

Copyright @ 2010 Cancer Research UK. This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Background: α-Fetoprotein (AFP) is a tumour-associated antigen in hepatocellular carcinoma (HCC) and is a target for immunotherapy. However, there is little information on the pattern of CD4 (Th1) and CD8 (Tc1) T-cell response to AFP in patients with HCC and their association with the clinical characteristics of patients. Methods: We therefore analysed CD4 and CD8 T-cell responses to a panel of AFP-derived peptides in a total of 31 HCC patients and 14 controls, using an intracellular cytokine assay for IFN-γ. Results: Anti-AFP Tc1 responses were detected in 28.5% of controls, as well as in 25% of HCC patients with Okuda I (early tumour stage) and in 31.6% of HCC patients with stage II or III (late tumour stages). An anti-AFP Th1 response was detected only in HCC patients (58.3% with Okuda stage I tumours and 15.8% with Okuda stage II or III tumours). Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations (P=0.00188), whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an anti-AFP Tc1 response. A Th1 response was detected in 44% of HCC patients with a Child–Pugh A score (early stage of cirrhosis), whereas this was detected in only 15% with a B or C score (late-stage cirrhosis). In contrast, a Tc1 response was detected in 17% of HCC patients with a Child–Pugh A score and in 46% with a B or C score. Conclusion: These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease (for both tumour stage and liver cirrhosis), whereas anti-AFP Tc1 responses are more likely to be present in patients with late-stage liver cirrhosis. Therefore, these data provide valuable information for the design of vaccination strategies against HCC.Association for International Cancer Research and Polkemmet Fund, London Clinic

Эффект УФ-облученных жирных кислот на спектральные свойства миоглобина

The efficiency of free radical oxidation of higher fatty acids (palmitic, oleic, linoleic, linolenic acids, complex of unsaturated fatty acids of omega-3 and omega-6 plant origin) under the influence of UV irradiation (λ = 180-400 nm) as a possible marker of lipid peroxidation is studied. Micelles of fatty acids (FA) in ethyl alcohol were used as a model of the lipid phase. The effect of UV irradiation on fatty acids was determined from the spectral changes of myoglobin in the region of the Soret band. The level of peroxide oxidation of the lipid phase at the same time was estimated from the accumulation of malonic dialdehyde as a well-known product of irradiation of phospholipids. The direct proportional dependence of the intensity of the difference spectrum of Mb (ΔD) on the number of double bonds in the molecule of oxidized fatty acids, as well as on the time of their UV irradiation and the accumulation of secondary LPO products is obtained. This shows that the spectral changes of Mb under the action of the pool of oxidized forms of fatty acids correlate well with the level of lipid phase peroxidation and can characterize the antioxidant potential of the blood when combined with the known antioxidant Trolox as a calibrator-inhibitor.Communicated by Corresponding Member Sergei A. UsanovИзучена эффективность свободнорадикального окисления высших жирных кислот (пальмитиновой, олеиновой, линолевой, линоленовой, комплекса непредельных жирных кислот ряда Омега-3 и Омега-6 растительного происхождения) под воздействием УФ-облучения (λ = 180-400 нм) как возможного маркера перекисного окисления липидной фазы. Мицеллы жирных кислот в этиловом спирте были использованы в качестве модели липидной фазы. Эффект УФ-облучения на жирные кислоты определяли по спектральным изменениям миоглобина в области полосы Соре. Уровень перекисного окисления липидной фазы в то же время оценивали по накоплению малонового диальдегида как хорошо известного продукта облучения фосфолипидов. Получена прямо пропорциональная зависимость интенсивности разностного спектра Mb (ΔD) от числа двойных связей в молекуле окисленных жирных кислот, а также от времени их УФ-облучения и накопления вторичных продуктов перекисного окисления липидов. Это показывает, что спектральные изменения Mb под действием пула окисленных форм жирных кислот хорошо коррелируют с уровнем перекисного окисления липидной фазы и могут охарактеризовать антиоксидантный потенциал крови при совместном использовании с известным антиоксидантом Тролоксом в качестве ингибитора-калибратора.Представлено членом-корреспондентом С. А. Усановы

THEORY OF GENERATIONS AS A TOOL FOR ANALYSIS, FORMATION AND DEVELOPMENT OF LABOUR POTENTIAL

The modern Strauss–Howe generational theory created at the intersection of economic, sociological, historical and psychological Sciences. She focuses primarily on difference of attitudes of generations, due to the specific social environment, corresponding to a certain period of time. Such a perspective on issues related to the human factor in the economy, has recently attracted interest not only from researchers, but also finds application for solving practical problems in some fields of business.Subject / theme. The article is devoted to one of the urgent contemporary socio-economic problems – the issue of the formation and development of labor potential. In this context, the theory of generations is offered by the authors as a tool for the study of qualitative parameters of human resources and the planning of future work opportunities in our country. In particular, the article considers the main aspects of the classical version of the Strauss–Howe generational theory and its Russian adaptation. Statistics describing the General demographics and working population of Russia from the point of view of generational groups. On this basis, a forecast is made of the labor potential of the country in the long term structure, review and compare the basic values and business characteristics of its constituent generations. Problem areas for which use of generational approach is rational are revealed and the corresponding recommendations are made.Objectives. The purpose of this article is justification of the possible application of provisions of modern theories of generations to identify and predict the dynamics of qualitative characteristics of the domestic workforce, as well as the prospects of its use in order to control the formation and development of labor potential.Methods. Methodological basis of the presented work make comparative and economic-statistical and socio-cultural methods of analysis.Results. In the framework of this article, the authors determined that of the five generations living in Russia today four groups constitute the major workforce of the country. At the same time in terms of labour potential for the future advisable to consider three generations, the evaluation value characteristics which showed significant differences in their social and personal attitudes that affect attitudes to education, the acquisition of professional skills and work as a whole. This situation carries the negative points, so it is important to establish quality of intergenerational interaction and choose the right vector of development of labor potential, aimed at the successful development of the domestic economy.Conclusions /significance. Practical value of the study is that the authors offer recommendations for the use of the theory of generations as a management tool can be applied in the framework of the tasks of formation and development of labour potential at the level of countries and individual organizations

SUSTAINABLE SOCIAL AND ECONOMIC DEVELOPMENT AS BASIS OF GEOPOLITICAL STABILITY

In article basics of innovative transformation of national economy and society are covered, negative tendencies of transitive transition to the new social and economic relations, including being expressed in decrease in enterprise activity are defined. In article it is proved that transition from industrialization to innovative economy and information society is possible only on condition of preservation of a sustainable development due to effective and rational operation of the cognitive resources forming strategic potential of balanced social and economic growth

Alleviating the toxicity concerns of antibacterial cinnamon‐polycaprolactone biomaterials for healthcare‐related biomedical applications

Abstract Fibrous constructs with incorporated cinnamon‐extract have previously been shown to have potent antifungal abilities. The question remains to whether these constructs are useful in the prevention of bacterial infections in fiber form and what the antimicrobial effects means in terms of toxicity to the native physiological cells. In this work, cinnamon extract containing poly (ε‐caprolactone) (PCL) fibers were successfully manufactured by pressurized gyration and had an average size of ∼2 μm. Cinnamon extract containing PCL fibers were tested against Escherichia coli, Staphylococcus aureus, Methicillin resistant staphylococcus aureus, and Enterococcus faecalis bacterial species to assess their antibacterial capacity; it was found that these fibers were able to reduce viable cell numbers of the bacterial species up to two orders of magnitude lower than the control group. The results of the antibacterial tests were assessed by scanning electron microscopy (SEM). The constructs were also tested under indirect MTT tests where they showed little to no toxicity, similar to the control groups. Additionally, cell viability fluorescent imaging displayed no significant toxicity issues with the fibers, even at their highest tested concentration. Here we present a viable method for the production the non‐toxic and naturally abundant cinnamon extracted fibers for numerous biomedical applications